{"id":2169,"date":"2026-04-04T16:17:56","date_gmt":"2026-04-04T16:17:56","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=2169"},"modified":"2026-04-04T16:17:56","modified_gmt":"2026-04-04T16:17:56","slug":"journal-watch-base-editing-of-hbg1-and-hbg2-promoters-in-sickle-cell-disease","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2026\/04\/04\/journal-watch-base-editing-of-hbg1-and-hbg2-promoters-in-sickle-cell-disease\/","title":{"rendered":"Journal Watch: Base Editing of HBG1 and HBG2 Promoters in Sickle Cell Disease"},"content":{"rendered":"

In a recent report published in the New England Journal of Medicine, Gupta, Sharma, Frangoul, Kanter, Mapara, Dalal, Alavi, and colleagues described interim results from the phase 1\u20132 BEACON study evaluating ristoglogene autogetemcel (risto-cel) in patients with sickle cell disease. This base-editing approach targets the HBG1 and HBG2 promoters to increase fetal hemoglobin production while reducing sickle hemoglobin. Among 31 treated patients, investigators observed rapid engraftment, sustained fetal hemoglobin expression, and no severe vaso-occlusive crises beyond 60 days after the last red-cell transfusion. These findings support continued evaluation of this therapeutic strategy despite notable treatment-related risks. (https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2504835<\/a>)<\/p>\n","protected":false},"excerpt":{"rendered":"

In a recent report published in the New England Journal of Medicine, Gupta, Sharma, Frangoul, Kanter, Mapara, Dalal, Alavi, and colleagues described interim results from the phase 1\u20132 BEACON study evaluating ristoglogene autogetemcel (risto-cel) in patients with sickle cell disease. This base-editing approach targets the HBG1 and HBG2 promoters to increase fetal hemoglobin production while […]<\/p>\n

Read More…<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2169","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"\nJournal Watch: Base Editing of HBG1 and HBG2 Promoters in Sickle Cell Disease - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2026\/04\/04\/journal-watch-base-editing-of-hbg1-and-hbg2-promoters-in-sickle-cell-disease\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Journal Watch: Base Editing of HBG1 and HBG2 Promoters in Sickle Cell Disease - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"In a recent report published in the New England Journal of Medicine, Gupta, Sharma, Frangoul, Kanter, Mapara, Dalal, Alavi, and colleagues described interim results from the phase 1\u20132 BEACON study evaluating ristoglogene autogetemcel (risto-cel) in patients with sickle cell disease. This base-editing approach targets the HBG1 and HBG2 promoters to increase fetal hemoglobin production while [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2026\/04\/04\/journal-watch-base-editing-of-hbg1-and-hbg2-promoters-in-sickle-cell-disease\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2026-04-04T16:17:56+00:00\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2026\\\/04\\\/04\\\/journal-watch-base-editing-of-hbg1-and-hbg2-promoters-in-sickle-cell-disease\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2026\\\/04\\\/04\\\/journal-watch-base-editing-of-hbg1-and-hbg2-promoters-in-sickle-cell-disease\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Journal Watch: Base Editing of HBG1 and HBG2 Promoters in Sickle Cell Disease\",\"datePublished\":\"2026-04-04T16:17:56+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2026\\\/04\\\/04\\\/journal-watch-base-editing-of-hbg1-and-hbg2-promoters-in-sickle-cell-disease\\\/\"},\"wordCount\":113,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2026\\\/04\\\/04\\\/journal-watch-base-editing-of-hbg1-and-hbg2-promoters-in-sickle-cell-disease\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2026\\\/04\\\/04\\\/journal-watch-base-editing-of-hbg1-and-hbg2-promoters-in-sickle-cell-disease\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2026\\\/04\\\/04\\\/journal-watch-base-editing-of-hbg1-and-hbg2-promoters-in-sickle-cell-disease\\\/\",\"name\":\"Journal Watch: Base Editing of HBG1 and HBG2 Promoters in Sickle Cell Disease - JMG Contact blog\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#website\"},\"datePublished\":\"2026-04-04T16:17:56+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2026\\\/04\\\/04\\\/journal-watch-base-editing-of-hbg1-and-hbg2-promoters-in-sickle-cell-disease\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2026\\\/04\\\/04\\\/journal-watch-base-editing-of-hbg1-and-hbg2-promoters-in-sickle-cell-disease\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2026\\\/04\\\/04\\\/journal-watch-base-editing-of-hbg1-and-hbg2-promoters-in-sickle-cell-disease\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Journal Watch: Base Editing of HBG1 and HBG2 Promoters in Sickle Cell Disease\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#website\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/\",\"name\":\"JMG Contact blog\",\"description\":\"JMG Contact blog\",\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\",\"name\":\"JMG Contact blog\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2017\\\/10\\\/blog-logo-jmg.png\",\"contentUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2017\\\/10\\\/blog-logo-jmg.png\",\"width\":300,\"height\":34,\"caption\":\"JMG Contact blog\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\",\"name\":\"hqqu\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g\",\"caption\":\"hqqu\"},\"description\":\"Huiqi Qu has a background as a physician trained in internal medicine and a PhD in Experimental Medicine (Endocrinology). His research applies human genetics and multi-omics to complex and pediatric diseases, including GWAS, polygenic risk scores (PRS), single-cell transcriptomics, and integrative genomics to support precision medicine and clinical translation.\",\"sameAs\":[\"https:\\\/\\\/x.com\\\/HuiQiQu\"],\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/author\\\/hqiqu\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Journal Watch: Base Editing of HBG1 and HBG2 Promoters in Sickle Cell Disease - JMG Contact blog","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/blogs.bmj.com\/jmg\/2026\/04\/04\/journal-watch-base-editing-of-hbg1-and-hbg2-promoters-in-sickle-cell-disease\/","og_locale":"en_US","og_type":"article","og_title":"Journal Watch: Base Editing of HBG1 and HBG2 Promoters in Sickle Cell Disease - JMG Contact blog","og_description":"In a recent report published in the New England Journal of Medicine, Gupta, Sharma, Frangoul, Kanter, Mapara, Dalal, Alavi, and colleagues described interim results from the phase 1\u20132 BEACON study evaluating ristoglogene autogetemcel (risto-cel) in patients with sickle cell disease. This base-editing approach targets the HBG1 and HBG2 promoters to increase fetal hemoglobin production while [...]Read More...","og_url":"https:\/\/blogs.bmj.com\/jmg\/2026\/04\/04\/journal-watch-base-editing-of-hbg1-and-hbg2-promoters-in-sickle-cell-disease\/","og_site_name":"JMG Contact blog","article_published_time":"2026-04-04T16:17:56+00:00","author":"hqqu","twitter_card":"summary_large_image","twitter_creator":"@HuiQiQu","twitter_misc":{"Written by":"hqqu","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/blogs.bmj.com\/jmg\/2026\/04\/04\/journal-watch-base-editing-of-hbg1-and-hbg2-promoters-in-sickle-cell-disease\/#article","isPartOf":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2026\/04\/04\/journal-watch-base-editing-of-hbg1-and-hbg2-promoters-in-sickle-cell-disease\/"},"author":{"name":"hqqu","@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/person\/be0250f8d5b52412c3e7c222dabd591b"},"headline":"Journal Watch: Base Editing of HBG1 and HBG2 Promoters in Sickle Cell Disease","datePublished":"2026-04-04T16:17:56+00:00","mainEntityOfPage":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2026\/04\/04\/journal-watch-base-editing-of-hbg1-and-hbg2-promoters-in-sickle-cell-disease\/"},"wordCount":113,"commentCount":0,"publisher":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#organization"},"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/blogs.bmj.com\/jmg\/2026\/04\/04\/journal-watch-base-editing-of-hbg1-and-hbg2-promoters-in-sickle-cell-disease\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/blogs.bmj.com\/jmg\/2026\/04\/04\/journal-watch-base-editing-of-hbg1-and-hbg2-promoters-in-sickle-cell-disease\/","url":"https:\/\/blogs.bmj.com\/jmg\/2026\/04\/04\/journal-watch-base-editing-of-hbg1-and-hbg2-promoters-in-sickle-cell-disease\/","name":"Journal Watch: Base Editing of HBG1 and HBG2 Promoters in Sickle Cell Disease - JMG Contact blog","isPartOf":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#website"},"datePublished":"2026-04-04T16:17:56+00:00","breadcrumb":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2026\/04\/04\/journal-watch-base-editing-of-hbg1-and-hbg2-promoters-in-sickle-cell-disease\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/blogs.bmj.com\/jmg\/2026\/04\/04\/journal-watch-base-editing-of-hbg1-and-hbg2-promoters-in-sickle-cell-disease\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/blogs.bmj.com\/jmg\/2026\/04\/04\/journal-watch-base-editing-of-hbg1-and-hbg2-promoters-in-sickle-cell-disease\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/blogs.bmj.com\/jmg\/"},{"@type":"ListItem","position":2,"name":"Journal Watch: Base Editing of HBG1 and HBG2 Promoters in Sickle Cell Disease"}]},{"@type":"WebSite","@id":"https:\/\/blogs.bmj.com\/jmg\/#website","url":"https:\/\/blogs.bmj.com\/jmg\/","name":"JMG Contact blog","description":"JMG Contact blog","publisher":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/blogs.bmj.com\/jmg\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/blogs.bmj.com\/jmg\/#organization","name":"JMG Contact blog","url":"https:\/\/blogs.bmj.com\/jmg\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/logo\/image\/","url":"https:\/\/blogs.bmj.com\/jmg\/files\/2017\/10\/blog-logo-jmg.png","contentUrl":"https:\/\/blogs.bmj.com\/jmg\/files\/2017\/10\/blog-logo-jmg.png","width":300,"height":34,"caption":"JMG Contact blog"},"image":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/person\/be0250f8d5b52412c3e7c222dabd591b","name":"hqqu","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g","caption":"hqqu"},"description":"Huiqi Qu has a background as a physician trained in internal medicine and a PhD in Experimental Medicine (Endocrinology). His research applies human genetics and multi-omics to complex and pediatric diseases, including GWAS, polygenic risk scores (PRS), single-cell transcriptomics, and integrative genomics to support precision medicine and clinical translation.","sameAs":["https:\/\/x.com\/HuiQiQu"],"url":"https:\/\/blogs.bmj.com\/jmg\/author\/hqiqu\/"}]}},"_links":{"self":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/2169","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/users\/123"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/comments?post=2169"}],"version-history":[{"count":0,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/2169\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/media?parent=2169"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/categories?post=2169"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/tags?post=2169"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}