{"id":2167,"date":"2026-04-03T21:46:09","date_gmt":"2026-04-03T21:46:09","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=2167"},"modified":"2026-04-03T21:46:24","modified_gmt":"2026-04-03T21:46:24","slug":"expanded-carrier-screening-in-a-southwestern-chinese-population-indicates-east-asian-specific-low-frequency-pathogenic-variants-account-for-nearly-half-of-the-at-risk-couple-rate-contributed-by-sha-l","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2026\/04\/03\/expanded-carrier-screening-in-a-southwestern-chinese-population-indicates-east-asian-specific-low-frequency-pathogenic-variants-account-for-nearly-half-of-the-at-risk-couple-rate-contributed-by-sha-l\/","title":{"rendered":"Expanded carrier screening in a Southwestern Chinese population indicates East Asian specific low-frequency pathogenic variants account for nearly half of the at-risk couple rate (Contributed by Sha Liu)"},"content":{"rendered":"

A study of over 3,700 people in China found that carrying hidden gene variants is common. Certain variants found mainly in East Asians significantly influence the chance that both partners carry the same condition. Screening based only on global data may miss these variants. Incorporating population-specific information can therefore provide a clearer picture for genetic counseling and family planning. (https:\/\/jmg.bmj.com\/content\/early\/2026\/04\/03\/jmg-2025-111273<\/a>)<\/p>\n","protected":false},"excerpt":{"rendered":"

A study of over 3,700 people in China found that carrying hidden gene variants is common. Certain variants found mainly in East Asians significantly influence the chance that both partners carry the same condition. Screening based only on global data may miss these variants. Incorporating population-specific information can therefore provide a clearer picture for genetic […]<\/p>\n

Read More…<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2167","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"\nExpanded carrier screening in a Southwestern Chinese population indicates East Asian specific low-frequency pathogenic variants account for nearly half of the at-risk couple rate (Contributed by Sha Liu) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2026\/04\/03\/expanded-carrier-screening-in-a-southwestern-chinese-population-indicates-east-asian-specific-low-frequency-pathogenic-variants-account-for-nearly-half-of-the-at-risk-couple-rate-contributed-by-sha-l\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Expanded carrier screening in a Southwestern Chinese population indicates East Asian specific low-frequency pathogenic variants account for nearly half of the at-risk couple rate (Contributed by Sha Liu) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"A study of over 3,700 people in China found that carrying hidden gene variants is common. 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