{"id":2152,"date":"2026-03-02T00:30:04","date_gmt":"2026-03-02T00:30:04","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=2152"},"modified":"2026-03-02T00:30:04","modified_gmt":"2026-03-02T00:30:04","slug":"clinically-significant-dna-variation-from-the-gencov-and-hostseq-covid-19-genome-sequencing-studies-contributed-by-erika-frangione","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2026\/03\/02\/clinically-significant-dna-variation-from-the-gencov-and-hostseq-covid-19-genome-sequencing-studies-contributed-by-erika-frangione\/","title":{"rendered":"Clinically significant DNA variation from the GENCOV and HostSeq COVID-19 genome sequencing studies (Contributed by Erika Frangione)"},"content":{"rendered":"<p>Large-scale Canadian genome research studies like HostSeq provide researchers with an opportunity to study genetic variation in the Canadian population. Sharing this data with public databases such as ClinVar is important for advancing our understanding of genetic changes associated with disease risk and susceptibility. However, these databases are often incomplete or contain conflicting information. By summarizing and comparing the genetic data from thousands of HostSeq participants to the data in ClinVar, this research found that a considerable portion of disease-associated variation was missing or inconsistently described in the database, highlighting a need for regular review and re-evaluation to keep public databases accurate and reliable. (<a href=\"https:\/\/jmg.bmj.com\/content\/early\/2026\/02\/27\/jmg-2025-111029\">https:\/\/jmg.bmj.com\/content\/early\/2026\/02\/27\/jmg-2025-111029<\/a>)<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Large-scale Canadian genome research studies like HostSeq provide researchers with an opportunity to study genetic variation in the Canadian population. Sharing this data with public databases such as ClinVar is important for advancing our understanding of genetic changes associated with disease risk and susceptibility. However, these databases are often incomplete or contain conflicting information. By [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2026\/03\/02\/clinically-significant-dna-variation-from-the-gencov-and-hostseq-covid-19-genome-sequencing-studies-contributed-by-erika-frangione\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2152","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Clinically significant DNA variation from the GENCOV and HostSeq COVID-19 genome sequencing studies (Contributed by Erika Frangione) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2026\/03\/02\/clinically-significant-dna-variation-from-the-gencov-and-hostseq-covid-19-genome-sequencing-studies-contributed-by-erika-frangione\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Clinically significant DNA variation from the GENCOV and HostSeq COVID-19 genome sequencing studies (Contributed by Erika Frangione) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Large-scale Canadian genome research studies like HostSeq provide researchers with an opportunity to study genetic variation in the Canadian population. Sharing this data with public databases such as ClinVar is important for advancing our understanding of genetic changes associated with disease risk and susceptibility. However, these databases are often incomplete or contain conflicting information. By [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2026\/03\/02\/clinically-significant-dna-variation-from-the-gencov-and-hostseq-covid-19-genome-sequencing-studies-contributed-by-erika-frangione\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2026-03-02T00:30:04+00:00\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2026\\\/03\\\/02\\\/clinically-significant-dna-variation-from-the-gencov-and-hostseq-covid-19-genome-sequencing-studies-contributed-by-erika-frangione\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2026\\\/03\\\/02\\\/clinically-significant-dna-variation-from-the-gencov-and-hostseq-covid-19-genome-sequencing-studies-contributed-by-erika-frangione\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Clinically significant DNA variation from the GENCOV and HostSeq COVID-19 genome sequencing studies (Contributed by Erika Frangione)\",\"datePublished\":\"2026-03-02T00:30:04+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2026\\\/03\\\/02\\\/clinically-significant-dna-variation-from-the-gencov-and-hostseq-covid-19-genome-sequencing-studies-contributed-by-erika-frangione\\\/\"},\"wordCount\":129,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2026\\\/03\\\/02\\\/clinically-significant-dna-variation-from-the-gencov-and-hostseq-covid-19-genome-sequencing-studies-contributed-by-erika-frangione\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2026\\\/03\\\/02\\\/clinically-significant-dna-variation-from-the-gencov-and-hostseq-covid-19-genome-sequencing-studies-contributed-by-erika-frangione\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2026\\\/03\\\/02\\\/clinically-significant-dna-variation-from-the-gencov-and-hostseq-covid-19-genome-sequencing-studies-contributed-by-erika-frangione\\\/\",\"name\":\"Clinically significant DNA variation from the GENCOV and HostSeq COVID-19 genome sequencing studies (Contributed by Erika Frangione) - 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