{"id":2120,"date":"2025-10-24T18:52:40","date_gmt":"2025-10-24T18:52:40","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=2120"},"modified":"2026-02-22T00:18:10","modified_gmt":"2026-02-22T00:18:10","slug":"dental-agenesis-as-a-novel-phenotypic-feature-associated-with-hereditary-diffuse-gastric-cancer-in-china","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2025\/10\/24\/dental-agenesis-as-a-novel-phenotypic-feature-associated-with-hereditary-diffuse-gastric-cancer-in-china\/","title":{"rendered":"Dental Agenesis as a Novel Phenotypic Feature Associated with Hereditary Diffuse Gastric Cancer in China (Contributed by Dr Lin Dong)"},"content":{"rendered":"

Hereditary diffuse gastric cancer (HDGC) is a\u00a0rare hereditary disease\u00a0of gastric cancer caused by germline variants in the\u00a0CDH1<\/em>\u00a0gene. In our study of 121 Chinese patients with gastric cancer, we identified three individuals carrying\u00a0CDH1\u00a0<\/em>mutations. Two of them also presented with congenital tooth agenesis, a feature rarely documented in HDGC, particularly in East Asian populations. This observation suggests that developmental traits such as missing teeth may provide unexpected clues for the early recognition of\u00a0CDH1<\/em> germline mutation carriers at risk, supporting timely genetic testing, counselling, and surveillance. (https:\/\/jmg.bmj.com\/content\/early\/2025\/10\/22\/jmg-2025-111081<\/a> )<\/p>\n","protected":false},"excerpt":{"rendered":"

Hereditary diffuse gastric cancer (HDGC) is a\u00a0rare hereditary disease\u00a0of gastric cancer caused by germline variants in the\u00a0CDH1\u00a0gene. In our study of 121 Chinese patients with gastric cancer, we identified three individuals carrying\u00a0CDH1\u00a0mutations. Two of them also presented with congenital tooth agenesis, a feature rarely documented in HDGC, particularly in East Asian populations. This observation suggests […]<\/p>\n

Read More…<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2120","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"\nDental Agenesis as a Novel Phenotypic Feature Associated with Hereditary Diffuse Gastric Cancer in China (Contributed by Dr Lin Dong) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2025\/10\/24\/dental-agenesis-as-a-novel-phenotypic-feature-associated-with-hereditary-diffuse-gastric-cancer-in-china\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dental Agenesis as a Novel Phenotypic Feature Associated with Hereditary Diffuse Gastric Cancer in China (Contributed by Dr Lin Dong) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Hereditary diffuse gastric cancer (HDGC) is a\u00a0rare hereditary disease\u00a0of gastric cancer caused by germline variants in the\u00a0CDH1\u00a0gene. 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