{"id":2109,"date":"2025-09-10T18:57:22","date_gmt":"2025-09-10T18:57:22","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=2109"},"modified":"2026-02-22T00:50:44","modified_gmt":"2026-02-22T00:50:44","slug":"exploring-the-unique-characteristics-of-genes-with-dual-autosomal-dominant-and-recessive-inheritance-mechanisms-phenotypes-and-candidate-identification","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2025\/09\/10\/exploring-the-unique-characteristics-of-genes-with-dual-autosomal-dominant-and-recessive-inheritance-mechanisms-phenotypes-and-candidate-identification\/","title":{"rendered":"Exploring the unique characteristics of genes with dual autosomal dominant and recessive inheritance: mechanisms, phenotypes and candidate identification (Contributed by Dr Tamar Harel)"},"content":{"rendered":"

Most genes linked to inherited diseases follow either a dominant or recessive pattern, but some genes can cause disease through both modes. This study investigated these unusual \u201cdual-inheritance\u201d genes. The researchers compiled a list of 562 such genes and identified key features that set them apart, and other features that were intermediate between the two classical groups. The researchers also found new genes that might belong to this category, which had previously been classified as dominant only. Understanding these genes is important because genetic variants that don\u2019t fit expected inheritance patterns can be missed or misinterpreted. This work could improve genetic diagnoses and deepen our understanding of how inherited diseases develop. (https:\/\/jmg.bmj.com\/content\/early\/2025\/08\/06\/jmg-2025-110872<\/a> )<\/p>\n","protected":false},"excerpt":{"rendered":"

Most genes linked to inherited diseases follow either a dominant or recessive pattern, but some genes can cause disease through both modes. This study investigated these unusual \u201cdual-inheritance\u201d genes. The researchers compiled a list of 562 such genes and identified key features that set them apart, and other features that were intermediate between the two […]<\/p>\n

Read More…<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2109","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"\nExploring the unique characteristics of genes with dual autosomal dominant and recessive inheritance: mechanisms, phenotypes and candidate identification (Contributed by Dr Tamar Harel) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2025\/09\/10\/exploring-the-unique-characteristics-of-genes-with-dual-autosomal-dominant-and-recessive-inheritance-mechanisms-phenotypes-and-candidate-identification\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exploring the unique characteristics of genes with dual autosomal dominant and recessive inheritance: mechanisms, phenotypes and candidate identification (Contributed by Dr Tamar Harel) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Most genes linked to inherited diseases follow either a dominant or recessive pattern, but some genes can cause disease through both modes. 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