{"id":2052,"date":"2025-03-13T16:39:47","date_gmt":"2025-03-13T16:39:47","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=2052"},"modified":"2026-02-22T01:15:05","modified_gmt":"2026-02-22T01:15:05","slug":"intrinsic-limitations-of-genomics-to-predict-and-treat-autism-a-disorder-born-in-the-womb","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2025\/03\/13\/intrinsic-limitations-of-genomics-to-predict-and-treat-autism-a-disorder-born-in-the-womb\/","title":{"rendered":"Intrinsic limitations of genomics to predict and treat autism a disorder born in the womb (Contributed by Dr Yehezkel Ben-Ari)"},"content":{"rendered":"

Autism is not “simply” a genetic disorder because<\/p>\n

    \n
  1. i) the mathematical equation used in genomics is flawed with inadequate estimations of essential parameters (GWAS and twin studies)<\/li>\n
  2. ii) The fact that Autism is born in the Womb completely modifies the investigations needed to understand and treat it. Analyzing by Machine learning non-genetic data in French Maternities, we identify at birth almost all babies who will be neurotypic and half those who will be autistic later. The “inaugurating” insult deviates developmental programs leading to immature neurons that are the final cause of the disorder and interrupts a direct link between the insult and the sequels.<\/li>\n<\/ol>\n

    iii) Therefore, to treat autism, we must develop drugs that shuts down specifically these immature currents and have started doing that with some success.<\/p>\n

    (https:\/\/jmg.bmj.com\/content\/early\/2025\/03\/11\/jmg-2024-110224<\/a> )<\/p>\n","protected":false},"excerpt":{"rendered":"

    Autism is not “simply” a genetic disorder because i) the mathematical equation used in genomics is flawed with inadequate estimations of essential parameters (GWAS and twin studies) ii) The fact that Autism is born in the Womb completely modifies the investigations needed to understand and treat it. Analyzing by Machine learning non-genetic data in French […]<\/p>\n

    Read More…<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2052","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"\nIntrinsic limitations of genomics to predict and treat autism a disorder born in the womb (Contributed by Dr Yehezkel Ben-Ari) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2025\/03\/13\/intrinsic-limitations-of-genomics-to-predict-and-treat-autism-a-disorder-born-in-the-womb\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Intrinsic limitations of genomics to predict and treat autism a disorder born in the womb (Contributed by Dr Yehezkel Ben-Ari) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Autism is not “simply” a genetic disorder because i) the mathematical equation used in genomics is flawed with inadequate estimations of essential parameters (GWAS and twin studies) ii) The fact that Autism is born in the Womb completely modifies the investigations needed to understand and treat it. 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