{"id":2036,"date":"2025-01-14T17:54:23","date_gmt":"2025-01-14T17:54:23","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=2036"},"modified":"2026-02-22T01:21:23","modified_gmt":"2026-02-22T01:21:23","slug":"aortic-and-arterial-manifestations-and-clinical-features-in-tgfb3-related-heritable-thoracic-aortic-disease-results-from-the-montalcino-aortic-consortium","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2025\/01\/14\/aortic-and-arterial-manifestations-and-clinical-features-in-tgfb3-related-heritable-thoracic-aortic-disease-results-from-the-montalcino-aortic-consortium\/","title":{"rendered":"Aortic and Arterial Manifestations and Clinical Features in TGFB3-Related Heritable Thoracic Aortic Disease: Results from the Montalcino Aortic Consortium (Contributed by Dr. Michelle Su-Anne Lim)"},"content":{"rendered":"<p>This paper describes clinical features and aortic outcomes in patients with heritable thoracic aortic disease (HTAD) due to <em>TGFB3<\/em> variants. Aortic dilation occurred in some but not all individuals, but aortic dissection (a tear in the aortic wall) occurred in very few patients and at older ages and at larger aortic diameters than in those with LDS due to other genetic variants. Thus, the aortic disease in TGFB3-related HTAD is less severe than other forms of LDS. In patients with <em>TGFB3<\/em>-related HTAD, lifelong surveillance is required and surgery to replace the aorta is recommended when the aorta reaches 5 cm. (<a href=\"https:\/\/jmg.bmj.com\/content\/early\/2024\/12\/09\/jmg-2024-110251\">https:\/\/jmg.bmj.com\/content\/early\/2024\/12\/09\/jmg-2024-110251<\/a> )<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>This paper describes clinical features and aortic outcomes in patients with heritable thoracic aortic disease (HTAD) due to TGFB3 variants. Aortic dilation occurred in some but not all individuals, but aortic dissection (a tear in the aortic wall) occurred in very few patients and at older ages and at larger aortic diameters than in those [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2025\/01\/14\/aortic-and-arterial-manifestations-and-clinical-features-in-tgfb3-related-heritable-thoracic-aortic-disease-results-from-the-montalcino-aortic-consortium\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2036","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Aortic and Arterial Manifestations and Clinical Features in TGFB3-Related Heritable Thoracic Aortic Disease: Results from the Montalcino Aortic Consortium (Contributed by Dr. Michelle Su-Anne Lim) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2025\/01\/14\/aortic-and-arterial-manifestations-and-clinical-features-in-tgfb3-related-heritable-thoracic-aortic-disease-results-from-the-montalcino-aortic-consortium\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Aortic and Arterial Manifestations and Clinical Features in TGFB3-Related Heritable Thoracic Aortic Disease: Results from the Montalcino Aortic Consortium (Contributed by Dr. Michelle Su-Anne Lim) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"This paper describes clinical features and aortic outcomes in patients with heritable thoracic aortic disease (HTAD) due to TGFB3 variants. Aortic dilation occurred in some but not all individuals, but aortic dissection (a tear in the aortic wall) occurred in very few patients and at older ages and at larger aortic diameters than in those [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2025\/01\/14\/aortic-and-arterial-manifestations-and-clinical-features-in-tgfb3-related-heritable-thoracic-aortic-disease-results-from-the-montalcino-aortic-consortium\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2025-01-14T17:54:23+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-22T01:21:23+00:00\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2025\\\/01\\\/14\\\/aortic-and-arterial-manifestations-and-clinical-features-in-tgfb3-related-heritable-thoracic-aortic-disease-results-from-the-montalcino-aortic-consortium\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2025\\\/01\\\/14\\\/aortic-and-arterial-manifestations-and-clinical-features-in-tgfb3-related-heritable-thoracic-aortic-disease-results-from-the-montalcino-aortic-consortium\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Aortic and Arterial Manifestations and Clinical Features in TGFB3-Related Heritable Thoracic Aortic Disease: Results from the Montalcino Aortic Consortium (Contributed by Dr. Michelle Su-Anne Lim)\",\"datePublished\":\"2025-01-14T17:54:23+00:00\",\"dateModified\":\"2026-02-22T01:21:23+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2025\\\/01\\\/14\\\/aortic-and-arterial-manifestations-and-clinical-features-in-tgfb3-related-heritable-thoracic-aortic-disease-results-from-the-montalcino-aortic-consortium\\\/\"},\"wordCount\":135,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2025\\\/01\\\/14\\\/aortic-and-arterial-manifestations-and-clinical-features-in-tgfb3-related-heritable-thoracic-aortic-disease-results-from-the-montalcino-aortic-consortium\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2025\\\/01\\\/14\\\/aortic-and-arterial-manifestations-and-clinical-features-in-tgfb3-related-heritable-thoracic-aortic-disease-results-from-the-montalcino-aortic-consortium\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2025\\\/01\\\/14\\\/aortic-and-arterial-manifestations-and-clinical-features-in-tgfb3-related-heritable-thoracic-aortic-disease-results-from-the-montalcino-aortic-consortium\\\/\",\"name\":\"Aortic and Arterial Manifestations and Clinical Features in TGFB3-Related Heritable Thoracic Aortic Disease: Results from the Montalcino Aortic Consortium (Contributed by Dr. Michelle Su-Anne Lim) - 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