{"id":2031,"date":"2025-01-14T17:43:13","date_gmt":"2025-01-14T17:43:13","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=2031"},"modified":"2026-02-22T01:23:26","modified_gmt":"2026-02-22T01:23:26","slug":"estimating-cancer-risk-in-carriers-of-lynch-syndrome-variants-in-uk-biobank","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2025\/01\/14\/estimating-cancer-risk-in-carriers-of-lynch-syndrome-variants-in-uk-biobank\/","title":{"rendered":"Estimating cancer risk in carriers of Lynch syndrome variants in UK Biobank (Contributed by Eilidh Fummey)"},"content":{"rendered":"<p>Lynch syndrome (LS) is a genetic condition that increases risk of some cancers. Typically, cancer risk in LS is estimated using individuals with an individual or family history of cancer. This may upwardly bias estimates. We estimated cancer risk in LS using a population-based cohort not selected on history of cancer. These estimates were generally consistent with published estimates, supporting use of preventative treatment in LS diagnosed incidentally through genetic sequencing. However, endometrial cancer risk was not elevated in those with LS-causing variants in the <em>PMS2<\/em> gene. The effectiveness of endometrial cancer prevention in this group should be studied further. (<a href=\"https:\/\/jmg.bmj.com\/content\/61\/9\/861\">https:\/\/jmg.bmj.com\/content\/61\/9\/861<\/a> )<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lynch syndrome (LS) is a genetic condition that increases risk of some cancers. Typically, cancer risk in LS is estimated using individuals with an individual or family history of cancer. This may upwardly bias estimates. We estimated cancer risk in LS using a population-based cohort not selected on history of cancer. These estimates were generally [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2025\/01\/14\/estimating-cancer-risk-in-carriers-of-lynch-syndrome-variants-in-uk-biobank\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2031","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Estimating cancer risk in carriers of Lynch syndrome variants in UK Biobank (Contributed by Eilidh Fummey) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2025\/01\/14\/estimating-cancer-risk-in-carriers-of-lynch-syndrome-variants-in-uk-biobank\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Estimating cancer risk in carriers of Lynch syndrome variants in UK Biobank (Contributed by Eilidh Fummey) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Lynch syndrome (LS) is a genetic condition that increases risk of some cancers. Typically, cancer risk in LS is estimated using individuals with an individual or family history of cancer. This may upwardly bias estimates. We estimated cancer risk in LS using a population-based cohort not selected on history of cancer. These estimates were generally [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2025\/01\/14\/estimating-cancer-risk-in-carriers-of-lynch-syndrome-variants-in-uk-biobank\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2025-01-14T17:43:13+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-22T01:23:26+00:00\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2025\\\/01\\\/14\\\/estimating-cancer-risk-in-carriers-of-lynch-syndrome-variants-in-uk-biobank\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2025\\\/01\\\/14\\\/estimating-cancer-risk-in-carriers-of-lynch-syndrome-variants-in-uk-biobank\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Estimating cancer risk in carriers of Lynch syndrome variants in UK Biobank (Contributed by Eilidh Fummey)\",\"datePublished\":\"2025-01-14T17:43:13+00:00\",\"dateModified\":\"2026-02-22T01:23:26+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2025\\\/01\\\/14\\\/estimating-cancer-risk-in-carriers-of-lynch-syndrome-variants-in-uk-biobank\\\/\"},\"wordCount\":121,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2025\\\/01\\\/14\\\/estimating-cancer-risk-in-carriers-of-lynch-syndrome-variants-in-uk-biobank\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2025\\\/01\\\/14\\\/estimating-cancer-risk-in-carriers-of-lynch-syndrome-variants-in-uk-biobank\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2025\\\/01\\\/14\\\/estimating-cancer-risk-in-carriers-of-lynch-syndrome-variants-in-uk-biobank\\\/\",\"name\":\"Estimating cancer risk in carriers of Lynch syndrome variants in UK Biobank (Contributed by Eilidh Fummey) - JMG Contact blog\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#website\"},\"datePublished\":\"2025-01-14T17:43:13+00:00\",\"dateModified\":\"2026-02-22T01:23:26+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2025\\\/01\\\/14\\\/estimating-cancer-risk-in-carriers-of-lynch-syndrome-variants-in-uk-biobank\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2025\\\/01\\\/14\\\/estimating-cancer-risk-in-carriers-of-lynch-syndrome-variants-in-uk-biobank\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2025\\\/01\\\/14\\\/estimating-cancer-risk-in-carriers-of-lynch-syndrome-variants-in-uk-biobank\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Estimating cancer risk in carriers of Lynch syndrome variants in UK Biobank (Contributed by Eilidh Fummey)\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#website\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/\",\"name\":\"JMG Contact blog\",\"description\":\"JMG Contact blog\",\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\",\"name\":\"JMG Contact blog\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2017\\\/10\\\/blog-logo-jmg.png\",\"contentUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2017\\\/10\\\/blog-logo-jmg.png\",\"width\":300,\"height\":34,\"caption\":\"JMG Contact blog\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\",\"name\":\"hqqu\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g\",\"caption\":\"hqqu\"},\"description\":\"Huiqi Qu has a background as a physician trained in internal medicine and a PhD in Experimental Medicine (Endocrinology). His research applies human genetics and multi-omics to complex and pediatric diseases, including GWAS, polygenic risk scores (PRS), single-cell transcriptomics, and integrative genomics to support precision medicine and clinical translation.\",\"sameAs\":[\"https:\\\/\\\/x.com\\\/HuiQiQu\"],\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/author\\\/hqiqu\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Estimating cancer risk in carriers of Lynch syndrome variants in UK Biobank (Contributed by Eilidh Fummey) - JMG Contact blog","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/blogs.bmj.com\/jmg\/2025\/01\/14\/estimating-cancer-risk-in-carriers-of-lynch-syndrome-variants-in-uk-biobank\/","og_locale":"en_US","og_type":"article","og_title":"Estimating cancer risk in carriers of Lynch syndrome variants in UK Biobank (Contributed by Eilidh Fummey) - JMG Contact blog","og_description":"Lynch syndrome (LS) is a genetic condition that increases risk of some cancers. Typically, cancer risk in LS is estimated using individuals with an individual or family history of cancer. This may upwardly bias estimates. We estimated cancer risk in LS using a population-based cohort not selected on history of cancer. These estimates were generally [...]Read More...","og_url":"https:\/\/blogs.bmj.com\/jmg\/2025\/01\/14\/estimating-cancer-risk-in-carriers-of-lynch-syndrome-variants-in-uk-biobank\/","og_site_name":"JMG Contact blog","article_published_time":"2025-01-14T17:43:13+00:00","article_modified_time":"2026-02-22T01:23:26+00:00","author":"hqqu","twitter_card":"summary_large_image","twitter_creator":"@HuiQiQu","twitter_misc":{"Written by":"hqqu","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/blogs.bmj.com\/jmg\/2025\/01\/14\/estimating-cancer-risk-in-carriers-of-lynch-syndrome-variants-in-uk-biobank\/#article","isPartOf":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2025\/01\/14\/estimating-cancer-risk-in-carriers-of-lynch-syndrome-variants-in-uk-biobank\/"},"author":{"name":"hqqu","@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/person\/be0250f8d5b52412c3e7c222dabd591b"},"headline":"Estimating cancer risk in carriers of Lynch syndrome variants in UK Biobank (Contributed by Eilidh Fummey)","datePublished":"2025-01-14T17:43:13+00:00","dateModified":"2026-02-22T01:23:26+00:00","mainEntityOfPage":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2025\/01\/14\/estimating-cancer-risk-in-carriers-of-lynch-syndrome-variants-in-uk-biobank\/"},"wordCount":121,"commentCount":0,"publisher":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#organization"},"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/blogs.bmj.com\/jmg\/2025\/01\/14\/estimating-cancer-risk-in-carriers-of-lynch-syndrome-variants-in-uk-biobank\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/blogs.bmj.com\/jmg\/2025\/01\/14\/estimating-cancer-risk-in-carriers-of-lynch-syndrome-variants-in-uk-biobank\/","url":"https:\/\/blogs.bmj.com\/jmg\/2025\/01\/14\/estimating-cancer-risk-in-carriers-of-lynch-syndrome-variants-in-uk-biobank\/","name":"Estimating cancer risk in carriers of Lynch syndrome variants in UK Biobank (Contributed by Eilidh Fummey) - JMG Contact blog","isPartOf":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#website"},"datePublished":"2025-01-14T17:43:13+00:00","dateModified":"2026-02-22T01:23:26+00:00","breadcrumb":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2025\/01\/14\/estimating-cancer-risk-in-carriers-of-lynch-syndrome-variants-in-uk-biobank\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/blogs.bmj.com\/jmg\/2025\/01\/14\/estimating-cancer-risk-in-carriers-of-lynch-syndrome-variants-in-uk-biobank\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/blogs.bmj.com\/jmg\/2025\/01\/14\/estimating-cancer-risk-in-carriers-of-lynch-syndrome-variants-in-uk-biobank\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/blogs.bmj.com\/jmg\/"},{"@type":"ListItem","position":2,"name":"Estimating cancer risk in carriers of Lynch syndrome variants in UK Biobank (Contributed by Eilidh Fummey)"}]},{"@type":"WebSite","@id":"https:\/\/blogs.bmj.com\/jmg\/#website","url":"https:\/\/blogs.bmj.com\/jmg\/","name":"JMG Contact blog","description":"JMG Contact blog","publisher":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/blogs.bmj.com\/jmg\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/blogs.bmj.com\/jmg\/#organization","name":"JMG Contact blog","url":"https:\/\/blogs.bmj.com\/jmg\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/logo\/image\/","url":"https:\/\/blogs.bmj.com\/jmg\/files\/2017\/10\/blog-logo-jmg.png","contentUrl":"https:\/\/blogs.bmj.com\/jmg\/files\/2017\/10\/blog-logo-jmg.png","width":300,"height":34,"caption":"JMG Contact blog"},"image":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/person\/be0250f8d5b52412c3e7c222dabd591b","name":"hqqu","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g","caption":"hqqu"},"description":"Huiqi Qu has a background as a physician trained in internal medicine and a PhD in Experimental Medicine (Endocrinology). His research applies human genetics and multi-omics to complex and pediatric diseases, including GWAS, polygenic risk scores (PRS), single-cell transcriptomics, and integrative genomics to support precision medicine and clinical translation.","sameAs":["https:\/\/x.com\/HuiQiQu"],"url":"https:\/\/blogs.bmj.com\/jmg\/author\/hqiqu\/"}]}},"_links":{"self":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/2031","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/users\/123"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/comments?post=2031"}],"version-history":[{"count":0,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/2031\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/media?parent=2031"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/categories?post=2031"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/tags?post=2031"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}