{"id":2024,"date":"2024-12-16T16:17:01","date_gmt":"2024-12-16T16:17:01","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=2024"},"modified":"2026-02-22T01:25:41","modified_gmt":"2026-02-22T01:25:41","slug":"validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2024\/12\/16\/validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers\/","title":{"rendered":"Validation of the NCCN\/Yale criteria for the identification of CDH1 pathogenic variant carriers (Contributed by Xavier Llor, MD, PhD)"},"content":{"rendered":"<p>Individuals carrying mutations in the CDH1 gene are at increased risk of developing stomach cancer (lifetime risk 7-42%) and breast cancer (lifetime risk 37-55%). Identification of these individuals through genetic testing is important because these cancers can be prevented by prophylactic surgery or detected early with endoscopy and breast imaging. Guidelines recommend genetic testing when certain clinical criteria are met. We previously showed that the widely used international criteria detected a small fraction of CDH1 mutation carriers, and we proposed simpler and more sensitive criteria, which were recently adopted by the National Comprehensive Caner Network (NCCN). Now, using a much larger dataset of 708 known CDH1 mutation carriers, we validate our previous findings, demonstrating that our criteria detect 82.2% of CDH1 mutation carriers, while the previously standard international criteria detect only 23.6%. (<a href=\"https:\/\/jmg.bmj.com\/content\/early\/2024\/12\/13\/jmg-2024-110446\">https:\/\/jmg.bmj.com\/content\/early\/2024\/12\/13\/jmg-2024-110446<\/a> )<\/p>\n<p><a href=\"https:\/\/blogs.bmj.com\/jmg\/2024\/12\/16\/validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers\/untitled-77\/\" rel=\"attachment wp-att-2025\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-2025\" src=\"https:\/\/blogs.bmj.com\/jmg\/files\/2024\/12\/Untitled-300x182.jpg\" alt=\"\" width=\"300\" height=\"182\" srcset=\"https:\/\/blogs.bmj.com\/jmg\/files\/2024\/12\/Untitled-300x182.jpg 300w, https:\/\/blogs.bmj.com\/jmg\/files\/2024\/12\/Untitled-1024x621.jpg 1024w, https:\/\/blogs.bmj.com\/jmg\/files\/2024\/12\/Untitled-768x466.jpg 768w, https:\/\/blogs.bmj.com\/jmg\/files\/2024\/12\/Untitled-640x388.jpg 640w, https:\/\/blogs.bmj.com\/jmg\/files\/2024\/12\/Untitled.jpg 1103w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Individuals carrying mutations in the CDH1 gene are at increased risk of developing stomach cancer (lifetime risk 7-42%) and breast cancer (lifetime risk 37-55%). Identification of these individuals through genetic testing is important because these cancers can be prevented by prophylactic surgery or detected early with endoscopy and breast imaging. Guidelines recommend genetic testing when [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2024\/12\/16\/validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-2024","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Validation of the NCCN\/Yale criteria for the identification of CDH1 pathogenic variant carriers (Contributed by Xavier Llor, MD, PhD) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2024\/12\/16\/validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Validation of the NCCN\/Yale criteria for the identification of CDH1 pathogenic variant carriers (Contributed by Xavier Llor, MD, PhD) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Individuals carrying mutations in the CDH1 gene are at increased risk of developing stomach cancer (lifetime risk 7-42%) and breast cancer (lifetime risk 37-55%). Identification of these individuals through genetic testing is important because these cancers can be prevented by prophylactic surgery or detected early with endoscopy and breast imaging. Guidelines recommend genetic testing when [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2024\/12\/16\/validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2024-12-16T16:17:01+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-22T01:25:41+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/blogs.bmj.com\/jmg\/files\/2024\/12\/Untitled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1103\" \/>\n\t<meta property=\"og:image:height\" content=\"669\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2024\\\/12\\\/16\\\/validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2024\\\/12\\\/16\\\/validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Validation of the NCCN\\\/Yale criteria for the identification of CDH1 pathogenic variant carriers (Contributed by Xavier Llor, MD, PhD)\",\"datePublished\":\"2024-12-16T16:17:01+00:00\",\"dateModified\":\"2026-02-22T01:25:41+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2024\\\/12\\\/16\\\/validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers\\\/\"},\"wordCount\":157,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2024\\\/12\\\/16\\\/validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2024\\\/12\\\/Untitled-300x182.jpg\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2024\\\/12\\\/16\\\/validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2024\\\/12\\\/16\\\/validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2024\\\/12\\\/16\\\/validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers\\\/\",\"name\":\"Validation of the NCCN\\\/Yale criteria for the identification of CDH1 pathogenic variant carriers (Contributed by Xavier Llor, MD, PhD) - JMG Contact blog\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2024\\\/12\\\/16\\\/validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2024\\\/12\\\/16\\\/validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2024\\\/12\\\/Untitled-300x182.jpg\",\"datePublished\":\"2024-12-16T16:17:01+00:00\",\"dateModified\":\"2026-02-22T01:25:41+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2024\\\/12\\\/16\\\/validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2024\\\/12\\\/16\\\/validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2024\\\/12\\\/16\\\/validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers\\\/#primaryimage\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2024\\\/12\\\/Untitled.jpg\",\"contentUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2024\\\/12\\\/Untitled.jpg\",\"width\":1103,\"height\":669},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2024\\\/12\\\/16\\\/validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Validation of the NCCN\\\/Yale criteria for the identification of CDH1 pathogenic variant carriers (Contributed by Xavier Llor, MD, PhD)\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#website\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/\",\"name\":\"JMG Contact blog\",\"description\":\"JMG Contact blog\",\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\",\"name\":\"JMG Contact blog\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2017\\\/10\\\/blog-logo-jmg.png\",\"contentUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2017\\\/10\\\/blog-logo-jmg.png\",\"width\":300,\"height\":34,\"caption\":\"JMG Contact blog\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\",\"name\":\"hqqu\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g\",\"caption\":\"hqqu\"},\"description\":\"Huiqi Qu has a background as a physician trained in internal medicine and a PhD in Experimental Medicine (Endocrinology). His research applies human genetics and multi-omics to complex and pediatric diseases, including GWAS, polygenic risk scores (PRS), single-cell transcriptomics, and integrative genomics to support precision medicine and clinical translation.\",\"sameAs\":[\"https:\\\/\\\/x.com\\\/HuiQiQu\"],\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/author\\\/hqiqu\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Validation of the NCCN\/Yale criteria for the identification of CDH1 pathogenic variant carriers (Contributed by Xavier Llor, MD, PhD) - JMG Contact blog","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/blogs.bmj.com\/jmg\/2024\/12\/16\/validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers\/","og_locale":"en_US","og_type":"article","og_title":"Validation of the NCCN\/Yale criteria for the identification of CDH1 pathogenic variant carriers (Contributed by Xavier Llor, MD, PhD) - JMG Contact blog","og_description":"Individuals carrying mutations in the CDH1 gene are at increased risk of developing stomach cancer (lifetime risk 7-42%) and breast cancer (lifetime risk 37-55%). Identification of these individuals through genetic testing is important because these cancers can be prevented by prophylactic surgery or detected early with endoscopy and breast imaging. Guidelines recommend genetic testing when [...]Read More...","og_url":"https:\/\/blogs.bmj.com\/jmg\/2024\/12\/16\/validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers\/","og_site_name":"JMG Contact blog","article_published_time":"2024-12-16T16:17:01+00:00","article_modified_time":"2026-02-22T01:25:41+00:00","og_image":[{"width":1103,"height":669,"url":"https:\/\/blogs.bmj.com\/jmg\/files\/2024\/12\/Untitled.jpg","type":"image\/jpeg"}],"author":"hqqu","twitter_card":"summary_large_image","twitter_creator":"@HuiQiQu","twitter_misc":{"Written by":"hqqu","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/blogs.bmj.com\/jmg\/2024\/12\/16\/validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers\/#article","isPartOf":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2024\/12\/16\/validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers\/"},"author":{"name":"hqqu","@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/person\/be0250f8d5b52412c3e7c222dabd591b"},"headline":"Validation of the NCCN\/Yale criteria for the identification of CDH1 pathogenic variant carriers (Contributed by Xavier Llor, MD, PhD)","datePublished":"2024-12-16T16:17:01+00:00","dateModified":"2026-02-22T01:25:41+00:00","mainEntityOfPage":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2024\/12\/16\/validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers\/"},"wordCount":157,"commentCount":0,"publisher":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#organization"},"image":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2024\/12\/16\/validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers\/#primaryimage"},"thumbnailUrl":"https:\/\/blogs.bmj.com\/jmg\/files\/2024\/12\/Untitled-300x182.jpg","inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/blogs.bmj.com\/jmg\/2024\/12\/16\/validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/blogs.bmj.com\/jmg\/2024\/12\/16\/validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers\/","url":"https:\/\/blogs.bmj.com\/jmg\/2024\/12\/16\/validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers\/","name":"Validation of the NCCN\/Yale criteria for the identification of CDH1 pathogenic variant carriers (Contributed by Xavier Llor, MD, PhD) - JMG Contact blog","isPartOf":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#website"},"primaryImageOfPage":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2024\/12\/16\/validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers\/#primaryimage"},"image":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2024\/12\/16\/validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers\/#primaryimage"},"thumbnailUrl":"https:\/\/blogs.bmj.com\/jmg\/files\/2024\/12\/Untitled-300x182.jpg","datePublished":"2024-12-16T16:17:01+00:00","dateModified":"2026-02-22T01:25:41+00:00","breadcrumb":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2024\/12\/16\/validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/blogs.bmj.com\/jmg\/2024\/12\/16\/validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/blogs.bmj.com\/jmg\/2024\/12\/16\/validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers\/#primaryimage","url":"https:\/\/blogs.bmj.com\/jmg\/files\/2024\/12\/Untitled.jpg","contentUrl":"https:\/\/blogs.bmj.com\/jmg\/files\/2024\/12\/Untitled.jpg","width":1103,"height":669},{"@type":"BreadcrumbList","@id":"https:\/\/blogs.bmj.com\/jmg\/2024\/12\/16\/validation-of-the-nccn-yale-criteria-for-the-identification-of-cdh1-pathogenic-variant-carriers\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/blogs.bmj.com\/jmg\/"},{"@type":"ListItem","position":2,"name":"Validation of the NCCN\/Yale criteria for the identification of CDH1 pathogenic variant carriers (Contributed by Xavier Llor, MD, PhD)"}]},{"@type":"WebSite","@id":"https:\/\/blogs.bmj.com\/jmg\/#website","url":"https:\/\/blogs.bmj.com\/jmg\/","name":"JMG Contact blog","description":"JMG Contact blog","publisher":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/blogs.bmj.com\/jmg\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/blogs.bmj.com\/jmg\/#organization","name":"JMG Contact blog","url":"https:\/\/blogs.bmj.com\/jmg\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/logo\/image\/","url":"https:\/\/blogs.bmj.com\/jmg\/files\/2017\/10\/blog-logo-jmg.png","contentUrl":"https:\/\/blogs.bmj.com\/jmg\/files\/2017\/10\/blog-logo-jmg.png","width":300,"height":34,"caption":"JMG Contact blog"},"image":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/person\/be0250f8d5b52412c3e7c222dabd591b","name":"hqqu","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g","caption":"hqqu"},"description":"Huiqi Qu has a background as a physician trained in internal medicine and a PhD in Experimental Medicine (Endocrinology). His research applies human genetics and multi-omics to complex and pediatric diseases, including GWAS, polygenic risk scores (PRS), single-cell transcriptomics, and integrative genomics to support precision medicine and clinical translation.","sameAs":["https:\/\/x.com\/HuiQiQu"],"url":"https:\/\/blogs.bmj.com\/jmg\/author\/hqiqu\/"}]}},"_links":{"self":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/2024","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/users\/123"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/comments?post=2024"}],"version-history":[{"count":0,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/2024\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/media?parent=2024"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/categories?post=2024"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/tags?post=2024"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}