{"id":202,"date":"2011-09-23T18:45:25","date_gmt":"2011-09-23T18:45:25","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=202"},"modified":"2026-02-25T20:53:46","modified_gmt":"2026-02-25T20:53:46","slug":"germline-bap1-mutation-predisposes-to-uveal-melanoma-lung-adenocarcinoma-meningioma-and-other-cancers","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2011\/09\/23\/germline-bap1-mutation-predisposes-to-uveal-melanoma-lung-adenocarcinoma-meningioma-and-other-cancers\/","title":{"rendered":"Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancers (Contributed by Mohamed H. Abdel-Rahman, MD, PhD)"},"content":{"rendered":"<p>This study identified a novel hereditary cancer syndrome caused by a germline mutation in <em>BAP1<\/em> gene. The <em>BAP1<\/em> mutation predisposes patients to develop uveal (ocular) melanoma, lung carcinoma, meningioma and possibly other cancers most importantly, skin melanoma and mesothelioma. The results also suggest that the frequency of germline <em>BAP1<\/em> mutation is rather small in uveal melanoma. Study of the role of <em>BAP1<\/em> in development of different cancers in particular uveal melanoma, lung carcinoma, meningioma, mesothelioma and skin melanoma is highly warranted. (<a href=\"http:\/\/jmg.bmj.com\/content\/early\/2011\/09\/22\/jmedgenet-2011-100156.abstract?papetoc\">http:\/\/jmg.bmj.com\/content\/early\/2011\/09\/22\/jmedgenet-2011-100156.abstract?papetoc<\/a> )<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>This study identified a novel hereditary cancer syndrome caused by a germline mutation in BAP1 gene. The BAP1 mutation predisposes patients to develop uveal (ocular) melanoma, lung carcinoma, meningioma and possibly other cancers most importantly, skin melanoma and mesothelioma. The results also suggest that the frequency of germline BAP1 mutation is rather small in uveal [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2011\/09\/23\/germline-bap1-mutation-predisposes-to-uveal-melanoma-lung-adenocarcinoma-meningioma-and-other-cancers\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-202","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancers (Contributed by Mohamed H. Abdel-Rahman, MD, PhD) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2011\/09\/23\/germline-bap1-mutation-predisposes-to-uveal-melanoma-lung-adenocarcinoma-meningioma-and-other-cancers\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancers (Contributed by Mohamed H. Abdel-Rahman, MD, PhD) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"This study identified a novel hereditary cancer syndrome caused by a germline mutation in BAP1 gene. The BAP1 mutation predisposes patients to develop uveal (ocular) melanoma, lung carcinoma, meningioma and possibly other cancers most importantly, skin melanoma and mesothelioma. The results also suggest that the frequency of germline BAP1 mutation is rather small in uveal [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2011\/09\/23\/germline-bap1-mutation-predisposes-to-uveal-melanoma-lung-adenocarcinoma-meningioma-and-other-cancers\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2011-09-23T18:45:25+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-25T20:53:46+00:00\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2011\\\/09\\\/23\\\/germline-bap1-mutation-predisposes-to-uveal-melanoma-lung-adenocarcinoma-meningioma-and-other-cancers\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2011\\\/09\\\/23\\\/germline-bap1-mutation-predisposes-to-uveal-melanoma-lung-adenocarcinoma-meningioma-and-other-cancers\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancers (Contributed by Mohamed H. 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