{"id":1994,"date":"2024-08-07T17:32:38","date_gmt":"2024-08-07T17:32:38","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=1994"},"modified":"2026-02-22T01:39:52","modified_gmt":"2026-02-22T01:39:52","slug":"novel-truncating-germline-variant-reinforces-tinf2-as-a-susceptibility-gene-for-familial-non-medullary-thyroid-cancer","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2024\/08\/07\/novel-truncating-germline-variant-reinforces-tinf2-as-a-susceptibility-gene-for-familial-non-medullary-thyroid-cancer\/","title":{"rendered":"Novel truncating germline variant reinforces TINF2 as a susceptibility gene for familial non-medullary thyroid cancer (Contributed by Dr. Josep Oriola)"},"content":{"rendered":"

It has long been observed that there are families in which thyroid cancer occurs, but no clear causative genes have been found. Some reports showed that shelterin proteins (involved in telomeric regulation) could be related with susceptibility to thyroid cancer. We have found a genetic variant in the TINF2 gene, co-segregating in five affected members of one family. Our results and some previous data reinforce TINF2 gene as a susceptibility cause of familial thyroid and\/or melanoma cancers. Furthermore, we point out the importance of location of the variant into the gene to be classified as causative of cancer or not. (https:\/\/jmg.bmj.com\/content\/early\/2024\/08\/05\/jmg-2024-110185<\/a> )<\/p>\n","protected":false},"excerpt":{"rendered":"

It has long been observed that there are families in which thyroid cancer occurs, but no clear causative genes have been found. Some reports showed that shelterin proteins (involved in telomeric regulation) could be related with susceptibility to thyroid cancer. We have found a genetic variant in the TINF2 gene, co-segregating in five affected members […]<\/p>\n

Read More…<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1994","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"\nNovel truncating germline variant reinforces TINF2 as a susceptibility gene for familial non-medullary thyroid cancer (Contributed by Dr. Josep Oriola) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2024\/08\/07\/novel-truncating-germline-variant-reinforces-tinf2-as-a-susceptibility-gene-for-familial-non-medullary-thyroid-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Novel truncating germline variant reinforces TINF2 as a susceptibility gene for familial non-medullary thyroid cancer (Contributed by Dr. Josep Oriola) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"It has long been observed that there are families in which thyroid cancer occurs, but no clear causative genes have been found. 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