{"id":1979,"date":"2024-06-18T14:14:26","date_gmt":"2024-06-18T14:14:26","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=1979"},"modified":"2026-02-22T01:43:37","modified_gmt":"2026-02-22T01:43:37","slug":"de-novo-variants-in-kcnj3-are-associated-with-early-onset-epilepsy","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2024\/06\/18\/de-novo-variants-in-kcnj3-are-associated-with-early-onset-epilepsy\/","title":{"rendered":"De novo variants in KCNJ3 are associated with early-onset epilepsy (Contributed by Dr Lili Long)"},"content":{"rendered":"<p>Epilepsy is a common chronic neurological disorder characterized by recurring spontaneous seizures with cognitive and psychosocial comorbidities. Genetic factors play a crucial role in the cause of epilepsy. We report two patients with epilepsy carrying the variants in KCNJ3 gene, which encodes a potassium channel. For the patients, the seizures occurred at a young age and were under control after combined treatment. Electrophysiological analysis was performed and revealed that the KCNJ3 variants significantly compromised the current activities. Our findings suggest that the KCNJ3 variants are associated with early-onset epilepsy. Genetic testing of KCNJ3 in patients with epilepsy may serve as a strategy for precision medicine. (<a href=\"https:\/\/jmg.bmj.com\/content\/61\/4\/319\">https:\/\/jmg.bmj.com\/content\/61\/4\/319<\/a> )<\/p>\n<p>&nbsp;<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Epilepsy is a common chronic neurological disorder characterized by recurring spontaneous seizures with cognitive and psychosocial comorbidities. Genetic factors play a crucial role in the cause of epilepsy. We report two patients with epilepsy carrying the variants in KCNJ3 gene, which encodes a potassium channel. For the patients, the seizures occurred at a young age [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2024\/06\/18\/de-novo-variants-in-kcnj3-are-associated-with-early-onset-epilepsy\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1979","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>De novo variants in KCNJ3 are associated with early-onset epilepsy (Contributed by Dr Lili Long) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2024\/06\/18\/de-novo-variants-in-kcnj3-are-associated-with-early-onset-epilepsy\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"De novo variants in KCNJ3 are associated with early-onset epilepsy (Contributed by Dr Lili Long) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Epilepsy is a common chronic neurological disorder characterized by recurring spontaneous seizures with cognitive and psychosocial comorbidities. Genetic factors play a crucial role in the cause of epilepsy. We report two patients with epilepsy carrying the variants in KCNJ3 gene, which encodes a potassium channel. For the patients, the seizures occurred at a young age [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2024\/06\/18\/de-novo-variants-in-kcnj3-are-associated-with-early-onset-epilepsy\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2024-06-18T14:14:26+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-22T01:43:37+00:00\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2024\\\/06\\\/18\\\/de-novo-variants-in-kcnj3-are-associated-with-early-onset-epilepsy\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2024\\\/06\\\/18\\\/de-novo-variants-in-kcnj3-are-associated-with-early-onset-epilepsy\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"De novo variants in KCNJ3 are associated with early-onset epilepsy (Contributed by Dr Lili Long)\",\"datePublished\":\"2024-06-18T14:14:26+00:00\",\"dateModified\":\"2026-02-22T01:43:37+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2024\\\/06\\\/18\\\/de-novo-variants-in-kcnj3-are-associated-with-early-onset-epilepsy\\\/\"},\"wordCount\":126,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2024\\\/06\\\/18\\\/de-novo-variants-in-kcnj3-are-associated-with-early-onset-epilepsy\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2024\\\/06\\\/18\\\/de-novo-variants-in-kcnj3-are-associated-with-early-onset-epilepsy\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2024\\\/06\\\/18\\\/de-novo-variants-in-kcnj3-are-associated-with-early-onset-epilepsy\\\/\",\"name\":\"De novo variants in KCNJ3 are associated with early-onset epilepsy (Contributed by Dr Lili Long) - 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