{"id":1944,"date":"2024-03-21T14:58:43","date_gmt":"2024-03-21T14:58:43","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=1944"},"modified":"2026-02-22T23:17:35","modified_gmt":"2026-02-22T23:17:35","slug":"a-comparative-medical-genomics-approach-may-facilitate-the-interpretation-of-rare-missense-variation","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2024\/03\/21\/a-comparative-medical-genomics-approach-may-facilitate-the-interpretation-of-rare-missense-variation\/","title":{"rendered":"A comparative medical genomics approach may facilitate the interpretation of rare missense variation (Contributed by Bushra Haque MSc)"},"content":{"rendered":"<p>This study compares rare genetic variation in humans and in nine domestic animal species. We found that variants causing disease in these non-human animals tend to also cause disease in humans. The findings suggest that data from DNA sequencing in veterinary medicine could aid in interpreting rare genetic variation seen in the clinic. Our results support the need for more collaboration between previously siloed areas of genetics. With the anticipated surge in genome-wide sequencing in animal species over the next decade, integrating human and veterinary genomic datasets will maximize the utility of this \u201ccomparative medical genomics\u201d approach. (<a href=\"https:\/\/jmg.bmj.com\/content\/early\/2024\/03\/20\/jmg-2023-109760\">https:\/\/jmg.bmj.com\/content\/early\/2024\/03\/20\/jmg-2023-109760<\/a> )<\/p>\n<p><a href=\"https:\/\/blogs.bmj.com\/jmg\/2024\/03\/21\/a-comparative-medical-genomics-approach-may-facilitate-the-interpretation-of-rare-missense-variation\/figure_jmg_blog\/\" rel=\"attachment wp-att-1945\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-1945\" src=\"https:\/\/blogs.bmj.com\/jmg\/files\/2024\/03\/Figure_JMG_blog-300x235.jpeg\" alt=\"\" width=\"300\" height=\"235\" srcset=\"https:\/\/blogs.bmj.com\/jmg\/files\/2024\/03\/Figure_JMG_blog-300x235.jpeg 300w, https:\/\/blogs.bmj.com\/jmg\/files\/2024\/03\/Figure_JMG_blog-1024x801.jpeg 1024w, https:\/\/blogs.bmj.com\/jmg\/files\/2024\/03\/Figure_JMG_blog-768x601.jpeg 768w, https:\/\/blogs.bmj.com\/jmg\/files\/2024\/03\/Figure_JMG_blog-1536x1201.jpeg 1536w, https:\/\/blogs.bmj.com\/jmg\/files\/2024\/03\/Figure_JMG_blog-2048x1602.jpeg 2048w, https:\/\/blogs.bmj.com\/jmg\/files\/2024\/03\/Figure_JMG_blog-640x500.jpeg 640w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>This study compares rare genetic variation in humans and in nine domestic animal species. We found that variants causing disease in these non-human animals tend to also cause disease in humans. The findings suggest that data from DNA sequencing in veterinary medicine could aid in interpreting rare genetic variation seen in the clinic. Our results [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2024\/03\/21\/a-comparative-medical-genomics-approach-may-facilitate-the-interpretation-of-rare-missense-variation\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1944","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>A comparative medical genomics approach may facilitate the interpretation of rare missense variation (Contributed by Bushra Haque MSc) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2024\/03\/21\/a-comparative-medical-genomics-approach-may-facilitate-the-interpretation-of-rare-missense-variation\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A comparative medical genomics approach may facilitate the interpretation of rare missense variation (Contributed by Bushra Haque MSc) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"This study compares rare genetic variation in humans and in nine domestic animal species. We found that variants causing disease in these non-human animals tend to also cause disease in humans. The findings suggest that data from DNA sequencing in veterinary medicine could aid in interpreting rare genetic variation seen in the clinic. Our results [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2024\/03\/21\/a-comparative-medical-genomics-approach-may-facilitate-the-interpretation-of-rare-missense-variation\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2024-03-21T14:58:43+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-22T23:17:35+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/blogs.bmj.com\/jmg\/files\/2024\/03\/Figure_JMG_blog-scaled.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"2002\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2024\\\/03\\\/21\\\/a-comparative-medical-genomics-approach-may-facilitate-the-interpretation-of-rare-missense-variation\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2024\\\/03\\\/21\\\/a-comparative-medical-genomics-approach-may-facilitate-the-interpretation-of-rare-missense-variation\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"A comparative medical genomics approach may facilitate the interpretation of rare missense variation (Contributed by Bushra Haque MSc)\",\"datePublished\":\"2024-03-21T14:58:43+00:00\",\"dateModified\":\"2026-02-22T23:17:35+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2024\\\/03\\\/21\\\/a-comparative-medical-genomics-approach-may-facilitate-the-interpretation-of-rare-missense-variation\\\/\"},\"wordCount\":123,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2024\\\/03\\\/21\\\/a-comparative-medical-genomics-approach-may-facilitate-the-interpretation-of-rare-missense-variation\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2024\\\/03\\\/Figure_JMG_blog-300x235.jpeg\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2024\\\/03\\\/21\\\/a-comparative-medical-genomics-approach-may-facilitate-the-interpretation-of-rare-missense-variation\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2024\\\/03\\\/21\\\/a-comparative-medical-genomics-approach-may-facilitate-the-interpretation-of-rare-missense-variation\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2024\\\/03\\\/21\\\/a-comparative-medical-genomics-approach-may-facilitate-the-interpretation-of-rare-missense-variation\\\/\",\"name\":\"A comparative medical genomics approach may facilitate the interpretation of rare missense variation (Contributed by Bushra Haque MSc) - 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