{"id":1857,"date":"2023-06-15T12:12:54","date_gmt":"2023-06-15T12:12:54","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=1857"},"modified":"2026-02-23T00:10:48","modified_gmt":"2026-02-23T00:10:48","slug":"congenital-mirror-movements-are-associated-with-defective-polymerisation-of-rad51","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2023\/06\/15\/congenital-mirror-movements-are-associated-with-defective-polymerisation-of-rad51\/","title":{"rendered":"Congenital mirror movements are associated with defective polymerisation of RAD51 (Contributed by Drs Caroline Dubacq and Oriane Trouillard)"},"content":{"rendered":"

To date, only few mutations in the RAD51 gene were associated to Congenital Mirror Movements (CMM), a rare genetic disorder for which affected patients cannot perform unimanual or asymmetric bimanual movements. In our study, identification of new mutations in RAD51 allowed to confirm haploinsufficiency of RAD51 in CMM and to demonstrate that compensation at the protein levels can explain the incomplete penetrance of CMM. Moreover, the polymerization of mutated RAD51 proteins was altered. These molecular and cellular results represent a new step in deciphering why mutations in this gene are associated with CMM or other pathologies in humans. (https:\/\/jmg.bmj.com\/content\/early\/2023\/06\/11\/jmg-2023-109189<\/a> )<\/p>\n

\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

To date, only few mutations in the RAD51 gene were associated to Congenital Mirror Movements (CMM), a rare genetic disorder for which affected patients cannot perform unimanual or asymmetric bimanual movements. In our study, identification of new mutations in RAD51 allowed to confirm haploinsufficiency of RAD51 in CMM and to demonstrate that compensation at the […]<\/p>\n

Read More…<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1857","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"\nCongenital mirror movements are associated with defective polymerisation of RAD51 (Contributed by Drs Caroline Dubacq and Oriane Trouillard) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2023\/06\/15\/congenital-mirror-movements-are-associated-with-defective-polymerisation-of-rad51\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Congenital mirror movements are associated with defective polymerisation of RAD51 (Contributed by Drs Caroline Dubacq and Oriane Trouillard) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"To date, only few mutations in the RAD51 gene were associated to Congenital Mirror Movements (CMM), a rare genetic disorder for which affected patients cannot perform unimanual or asymmetric bimanual movements. In our study, identification of new mutations in RAD51 allowed to confirm haploinsufficiency of RAD51 in CMM and to demonstrate that compensation at the [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2023\/06\/15\/congenital-mirror-movements-are-associated-with-defective-polymerisation-of-rad51\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2023-06-15T12:12:54+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-23T00:10:48+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/blogs.bmj.com\/jmg\/files\/2023\/06\/Untitled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"703\" \/>\n\t<meta property=\"og:image:height\" content=\"1104\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2023\\\/06\\\/15\\\/congenital-mirror-movements-are-associated-with-defective-polymerisation-of-rad51\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2023\\\/06\\\/15\\\/congenital-mirror-movements-are-associated-with-defective-polymerisation-of-rad51\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Congenital mirror movements are associated with defective polymerisation of RAD51 (Contributed by Drs Caroline Dubacq and Oriane Trouillard)\",\"datePublished\":\"2023-06-15T12:12:54+00:00\",\"dateModified\":\"2026-02-23T00:10:48+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2023\\\/06\\\/15\\\/congenital-mirror-movements-are-associated-with-defective-polymerisation-of-rad51\\\/\"},\"wordCount\":124,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2023\\\/06\\\/15\\\/congenital-mirror-movements-are-associated-with-defective-polymerisation-of-rad51\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2023\\\/06\\\/Untitled-191x300.jpg\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2023\\\/06\\\/15\\\/congenital-mirror-movements-are-associated-with-defective-polymerisation-of-rad51\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2023\\\/06\\\/15\\\/congenital-mirror-movements-are-associated-with-defective-polymerisation-of-rad51\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2023\\\/06\\\/15\\\/congenital-mirror-movements-are-associated-with-defective-polymerisation-of-rad51\\\/\",\"name\":\"Congenital mirror movements are associated with defective polymerisation of RAD51 (Contributed by Drs Caroline Dubacq and Oriane Trouillard) - 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