{"id":1820,"date":"2023-01-13T15:44:57","date_gmt":"2023-01-13T15:44:57","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=1820"},"modified":"2026-02-23T00:20:52","modified_gmt":"2026-02-23T00:20:52","slug":"recurring-germline-mosaicism-in-a-family-due-to-reversion-of-an-inherited-derivative-chromosome-8-from-an-821-translocation-with-interstitial-telomeric-sequences","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2023\/01\/13\/recurring-germline-mosaicism-in-a-family-due-to-reversion-of-an-inherited-derivative-chromosome-8-from-an-821-translocation-with-interstitial-telomeric-sequences\/","title":{"rendered":"Recurring germline mosaicism in a family due to reversion of an inherited derivative chromosome 8 from an 8;21 translocation with interstitial telomeric sequences (Contributed by Dr. Weimin Bi)"},"content":{"rendered":"<p>Mosaicism (a mixture of normal cells and cells with an abnormal chromosome) is rarely seen in multiple family members. We studied a family spanning three generations that had an abnormal chromosome 8 with a small piece of chromosome 21 attached to its end (der(8)). Multiple family members also had cells with normal chromosomes resulting in different levels of mosaicism. Genetic testing showed that the instability of the genetic code sequence where the piece of chromosome 21 was joined to chromosome 8, likely caused loss of the extra piece of chromosome 21 thus changing the der(8) chromosome back to a normal chromosome 8. (<a href=\"https:\/\/jmg.bmj.com\/content\/early\/2022\/09\/23\/jmg-2022-108586\">https:\/\/jmg.bmj.com\/content\/early\/2022\/09\/23\/jmg-2022-108586<\/a> )<\/p>\n<p><a href=\"https:\/\/blogs.bmj.com\/jmg\/2023\/01\/13\/recurring-germline-mosaicism-in-a-family-due-to-reversion-of-an-inherited-derivative-chromosome-8-from-an-821-translocation-with-interstitial-telomeric-sequences\/figure-for-blog-9-30-2022\/\" rel=\"attachment wp-att-1821\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-1821\" src=\"https:\/\/blogs.bmj.com\/jmg\/files\/2023\/01\/figure-for-blog-9.30.2022-300x225.jpg\" alt=\"\" width=\"300\" height=\"225\" srcset=\"https:\/\/blogs.bmj.com\/jmg\/files\/2023\/01\/figure-for-blog-9.30.2022-300x225.jpg 300w, https:\/\/blogs.bmj.com\/jmg\/files\/2023\/01\/figure-for-blog-9.30.2022-768x576.jpg 768w, https:\/\/blogs.bmj.com\/jmg\/files\/2023\/01\/figure-for-blog-9.30.2022-640x480.jpg 640w, https:\/\/blogs.bmj.com\/jmg\/files\/2023\/01\/figure-for-blog-9.30.2022.jpg 960w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mosaicism (a mixture of normal cells and cells with an abnormal chromosome) is rarely seen in multiple family members. We studied a family spanning three generations that had an abnormal chromosome 8 with a small piece of chromosome 21 attached to its end (der(8)). Multiple family members also had cells with normal chromosomes resulting in [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2023\/01\/13\/recurring-germline-mosaicism-in-a-family-due-to-reversion-of-an-inherited-derivative-chromosome-8-from-an-821-translocation-with-interstitial-telomeric-sequences\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1820","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Recurring germline mosaicism in a family due to reversion of an inherited derivative chromosome 8 from an 8;21 translocation with interstitial telomeric sequences (Contributed by Dr. Weimin Bi) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2023\/01\/13\/recurring-germline-mosaicism-in-a-family-due-to-reversion-of-an-inherited-derivative-chromosome-8-from-an-821-translocation-with-interstitial-telomeric-sequences\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Recurring germline mosaicism in a family due to reversion of an inherited derivative chromosome 8 from an 8;21 translocation with interstitial telomeric sequences (Contributed by Dr. Weimin Bi) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Mosaicism (a mixture of normal cells and cells with an abnormal chromosome) is rarely seen in multiple family members. We studied a family spanning three generations that had an abnormal chromosome 8 with a small piece of chromosome 21 attached to its end (der(8)). Multiple family members also had cells with normal chromosomes resulting in [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2023\/01\/13\/recurring-germline-mosaicism-in-a-family-due-to-reversion-of-an-inherited-derivative-chromosome-8-from-an-821-translocation-with-interstitial-telomeric-sequences\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2023-01-13T15:44:57+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-23T00:20:52+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/blogs.bmj.com\/jmg\/files\/2023\/01\/figure-for-blog-9.30.2022.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"960\" \/>\n\t<meta property=\"og:image:height\" content=\"720\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2023\\\/01\\\/13\\\/recurring-germline-mosaicism-in-a-family-due-to-reversion-of-an-inherited-derivative-chromosome-8-from-an-821-translocation-with-interstitial-telomeric-sequences\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2023\\\/01\\\/13\\\/recurring-germline-mosaicism-in-a-family-due-to-reversion-of-an-inherited-derivative-chromosome-8-from-an-821-translocation-with-interstitial-telomeric-sequences\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Recurring germline mosaicism in a family due to reversion of an inherited derivative chromosome 8 from an 8;21 translocation with interstitial telomeric sequences (Contributed by Dr. Weimin Bi)\",\"datePublished\":\"2023-01-13T15:44:57+00:00\",\"dateModified\":\"2026-02-23T00:20:52+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2023\\\/01\\\/13\\\/recurring-germline-mosaicism-in-a-family-due-to-reversion-of-an-inherited-derivative-chromosome-8-from-an-821-translocation-with-interstitial-telomeric-sequences\\\/\"},\"wordCount\":130,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2023\\\/01\\\/13\\\/recurring-germline-mosaicism-in-a-family-due-to-reversion-of-an-inherited-derivative-chromosome-8-from-an-821-translocation-with-interstitial-telomeric-sequences\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2023\\\/01\\\/figure-for-blog-9.30.2022-300x225.jpg\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2023\\\/01\\\/13\\\/recurring-germline-mosaicism-in-a-family-due-to-reversion-of-an-inherited-derivative-chromosome-8-from-an-821-translocation-with-interstitial-telomeric-sequences\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2023\\\/01\\\/13\\\/recurring-germline-mosaicism-in-a-family-due-to-reversion-of-an-inherited-derivative-chromosome-8-from-an-821-translocation-with-interstitial-telomeric-sequences\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2023\\\/01\\\/13\\\/recurring-germline-mosaicism-in-a-family-due-to-reversion-of-an-inherited-derivative-chromosome-8-from-an-821-translocation-with-interstitial-telomeric-sequences\\\/\",\"name\":\"Recurring germline mosaicism in a family due to reversion of an inherited derivative chromosome 8 from an 8;21 translocation with interstitial telomeric sequences (Contributed by Dr. Weimin Bi) - 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