{"id":1704,"date":"2022-02-11T15:53:59","date_gmt":"2022-02-11T15:53:59","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=1704"},"modified":"2026-02-23T01:04:28","modified_gmt":"2026-02-23T01:04:28","slug":"disorders-and-roles-of-tsrna-snorna-snrna-and-pirna-in-cancer","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2022\/02\/11\/disorders-and-roles-of-tsrna-snorna-snrna-and-pirna-in-cancer\/","title":{"rendered":"Disorders and roles of tsRNA, snoRNA, snRNA and piRNA in cancer (Contributed by Dr. Lin Xiao)"},"content":{"rendered":"

Non-coding RNAs are a large-scale and alloplasmatic family of RNAs. According to their size, small non-coding RNAs are approximately 18-200 nt. In recent years, increasing evidence has shown that small non-coding RNAs such as tsRNA, snoRNA, snRNA and piRNA play important roles in many biological processes, and their dysregulation is closely related to cancer progression. We review the research progress in the classification, biogenesis and biological function of these. Furthermore, we highlight their dysregulation and mechanisms of action in cancer and discuss their potential as diagnostic and prognostic biomarkers or therapeutic targets. (https:\/\/jmg.bmj.com\/content\/early\/2022\/02\/09\/jmedgenet-2021-108327<\/a> )<\/p>\n","protected":false},"excerpt":{"rendered":"

Non-coding RNAs are a large-scale and alloplasmatic family of RNAs. According to their size, small non-coding RNAs are approximately 18-200 nt. In recent years, increasing evidence has shown that small non-coding RNAs such as tsRNA, snoRNA, snRNA and piRNA play important roles in many biological processes, and their dysregulation is closely related to cancer progression. […]<\/p>\n

Read More…<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1704","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"\nDisorders and roles of tsRNA, snoRNA, snRNA and piRNA in cancer (Contributed by Dr. Lin Xiao) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2022\/02\/11\/disorders-and-roles-of-tsrna-snorna-snrna-and-pirna-in-cancer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Disorders and roles of tsRNA, snoRNA, snRNA and piRNA in cancer (Contributed by Dr. Lin Xiao) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Non-coding RNAs are a large-scale and alloplasmatic family of RNAs. According to their size, small non-coding RNAs are approximately 18-200 nt. In recent years, increasing evidence has shown that small non-coding RNAs such as tsRNA, snoRNA, snRNA and piRNA play important roles in many biological processes, and their dysregulation is closely related to cancer progression. [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2022\/02\/11\/disorders-and-roles-of-tsrna-snorna-snrna-and-pirna-in-cancer\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2022-02-11T15:53:59+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-23T01:04:28+00:00\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2022\\\/02\\\/11\\\/disorders-and-roles-of-tsrna-snorna-snrna-and-pirna-in-cancer\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2022\\\/02\\\/11\\\/disorders-and-roles-of-tsrna-snorna-snrna-and-pirna-in-cancer\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Disorders and roles of tsRNA, snoRNA, snRNA and piRNA in cancer (Contributed by Dr. Lin Xiao)\",\"datePublished\":\"2022-02-11T15:53:59+00:00\",\"dateModified\":\"2026-02-23T01:04:28+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2022\\\/02\\\/11\\\/disorders-and-roles-of-tsrna-snorna-snrna-and-pirna-in-cancer\\\/\"},\"wordCount\":116,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2022\\\/02\\\/11\\\/disorders-and-roles-of-tsrna-snorna-snrna-and-pirna-in-cancer\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2022\\\/02\\\/11\\\/disorders-and-roles-of-tsrna-snorna-snrna-and-pirna-in-cancer\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2022\\\/02\\\/11\\\/disorders-and-roles-of-tsrna-snorna-snrna-and-pirna-in-cancer\\\/\",\"name\":\"Disorders and roles of tsRNA, snoRNA, snRNA and piRNA in cancer (Contributed by Dr. Lin Xiao) - JMG Contact blog\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#website\"},\"datePublished\":\"2022-02-11T15:53:59+00:00\",\"dateModified\":\"2026-02-23T01:04:28+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2022\\\/02\\\/11\\\/disorders-and-roles-of-tsrna-snorna-snrna-and-pirna-in-cancer\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2022\\\/02\\\/11\\\/disorders-and-roles-of-tsrna-snorna-snrna-and-pirna-in-cancer\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2022\\\/02\\\/11\\\/disorders-and-roles-of-tsrna-snorna-snrna-and-pirna-in-cancer\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Disorders and roles of tsRNA, snoRNA, snRNA and piRNA in cancer (Contributed by Dr. Lin Xiao)\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#website\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/\",\"name\":\"JMG Contact blog\",\"description\":\"JMG Contact blog\",\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\",\"name\":\"JMG Contact blog\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2017\\\/10\\\/blog-logo-jmg.png\",\"contentUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2017\\\/10\\\/blog-logo-jmg.png\",\"width\":300,\"height\":34,\"caption\":\"JMG Contact blog\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\",\"name\":\"hqqu\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g\",\"caption\":\"hqqu\"},\"description\":\"Huiqi Qu has a background as a physician trained in internal medicine and a PhD in Experimental Medicine (Endocrinology). His research applies human genetics and multi-omics to complex and pediatric diseases, including GWAS, polygenic risk scores (PRS), single-cell transcriptomics, and integrative genomics to support precision medicine and clinical translation.\",\"sameAs\":[\"https:\\\/\\\/x.com\\\/HuiQiQu\"],\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/author\\\/hqiqu\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Disorders and roles of tsRNA, snoRNA, snRNA and piRNA in cancer (Contributed by Dr. Lin Xiao) - JMG Contact blog","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/blogs.bmj.com\/jmg\/2022\/02\/11\/disorders-and-roles-of-tsrna-snorna-snrna-and-pirna-in-cancer\/","og_locale":"en_US","og_type":"article","og_title":"Disorders and roles of tsRNA, snoRNA, snRNA and piRNA in cancer (Contributed by Dr. Lin Xiao) - JMG Contact blog","og_description":"Non-coding RNAs are a large-scale and alloplasmatic family of RNAs. According to their size, small non-coding RNAs are approximately 18-200 nt. In recent years, increasing evidence has shown that small non-coding RNAs such as tsRNA, snoRNA, snRNA and piRNA play important roles in many biological processes, and their dysregulation is closely related to cancer progression. [...]Read More...","og_url":"https:\/\/blogs.bmj.com\/jmg\/2022\/02\/11\/disorders-and-roles-of-tsrna-snorna-snrna-and-pirna-in-cancer\/","og_site_name":"JMG Contact blog","article_published_time":"2022-02-11T15:53:59+00:00","article_modified_time":"2026-02-23T01:04:28+00:00","author":"hqqu","twitter_card":"summary_large_image","twitter_creator":"@HuiQiQu","twitter_misc":{"Written by":"hqqu","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/blogs.bmj.com\/jmg\/2022\/02\/11\/disorders-and-roles-of-tsrna-snorna-snrna-and-pirna-in-cancer\/#article","isPartOf":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2022\/02\/11\/disorders-and-roles-of-tsrna-snorna-snrna-and-pirna-in-cancer\/"},"author":{"name":"hqqu","@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/person\/be0250f8d5b52412c3e7c222dabd591b"},"headline":"Disorders and roles of tsRNA, snoRNA, snRNA and piRNA in cancer (Contributed by Dr. Lin Xiao)","datePublished":"2022-02-11T15:53:59+00:00","dateModified":"2026-02-23T01:04:28+00:00","mainEntityOfPage":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2022\/02\/11\/disorders-and-roles-of-tsrna-snorna-snrna-and-pirna-in-cancer\/"},"wordCount":116,"commentCount":0,"publisher":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#organization"},"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/blogs.bmj.com\/jmg\/2022\/02\/11\/disorders-and-roles-of-tsrna-snorna-snrna-and-pirna-in-cancer\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/blogs.bmj.com\/jmg\/2022\/02\/11\/disorders-and-roles-of-tsrna-snorna-snrna-and-pirna-in-cancer\/","url":"https:\/\/blogs.bmj.com\/jmg\/2022\/02\/11\/disorders-and-roles-of-tsrna-snorna-snrna-and-pirna-in-cancer\/","name":"Disorders and roles of tsRNA, snoRNA, snRNA and piRNA in cancer (Contributed by Dr. Lin Xiao) - JMG Contact blog","isPartOf":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#website"},"datePublished":"2022-02-11T15:53:59+00:00","dateModified":"2026-02-23T01:04:28+00:00","breadcrumb":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2022\/02\/11\/disorders-and-roles-of-tsrna-snorna-snrna-and-pirna-in-cancer\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/blogs.bmj.com\/jmg\/2022\/02\/11\/disorders-and-roles-of-tsrna-snorna-snrna-and-pirna-in-cancer\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/blogs.bmj.com\/jmg\/2022\/02\/11\/disorders-and-roles-of-tsrna-snorna-snrna-and-pirna-in-cancer\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/blogs.bmj.com\/jmg\/"},{"@type":"ListItem","position":2,"name":"Disorders and roles of tsRNA, snoRNA, snRNA and piRNA in cancer (Contributed by Dr. Lin Xiao)"}]},{"@type":"WebSite","@id":"https:\/\/blogs.bmj.com\/jmg\/#website","url":"https:\/\/blogs.bmj.com\/jmg\/","name":"JMG Contact blog","description":"JMG Contact blog","publisher":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/blogs.bmj.com\/jmg\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/blogs.bmj.com\/jmg\/#organization","name":"JMG Contact blog","url":"https:\/\/blogs.bmj.com\/jmg\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/logo\/image\/","url":"https:\/\/blogs.bmj.com\/jmg\/files\/2017\/10\/blog-logo-jmg.png","contentUrl":"https:\/\/blogs.bmj.com\/jmg\/files\/2017\/10\/blog-logo-jmg.png","width":300,"height":34,"caption":"JMG Contact blog"},"image":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/person\/be0250f8d5b52412c3e7c222dabd591b","name":"hqqu","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g","caption":"hqqu"},"description":"Huiqi Qu has a background as a physician trained in internal medicine and a PhD in Experimental Medicine (Endocrinology). His research applies human genetics and multi-omics to complex and pediatric diseases, including GWAS, polygenic risk scores (PRS), single-cell transcriptomics, and integrative genomics to support precision medicine and clinical translation.","sameAs":["https:\/\/x.com\/HuiQiQu"],"url":"https:\/\/blogs.bmj.com\/jmg\/author\/hqiqu\/"}]}},"_links":{"self":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/1704","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/users\/123"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/comments?post=1704"}],"version-history":[{"count":0,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/1704\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/media?parent=1704"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/categories?post=1704"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/tags?post=1704"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}