{"id":1696,"date":"2022-01-17T20:23:23","date_gmt":"2022-01-17T20:23:23","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=1696"},"modified":"2026-02-23T01:06:00","modified_gmt":"2026-02-23T01:06:00","slug":"long-term-dormancy-in-a-brca1-heterozygote","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2022\/01\/17\/long-term-dormancy-in-a-brca1-heterozygote\/","title":{"rendered":"Long term dormancy in a BRCA1 heterozygote (Contributed by Drs. Setor Amuzu, Lili Fu, and William D Foulkes)"},"content":{"rendered":"

Germline pathogenic variants in BRCA1 or BRCA2 <\/em>genes increase the risk of ovarian high grade serous carcinoma, the most common and most lethal subtype of epithelial ovarian cancer. Carriers of these genetic variants are usually offered surgery known as risk-reducing salpingo-oophorectomy (RRSO) where the Fallopian tubes and ovaries are removed. We report the case of a woman carrying a germline pathogenic variant in BRCA1<\/em> who received RRSO but developed peritoneal cancer 15 years later. We reveal through DNA sequencing and analysis that the peritoneal cancer is a recurrence of a Fallopian tube cancer that was missed on initial pathologic examination. (https:\/\/jmg.bmj.com\/content\/early\/2022\/01\/16\/jmedgenet-2021-108269<\/a> )<\/p>\n

\"\"<\/a><\/p>\n

Related story by Sarah DeWeerdt: As the fallopian tubes come to the fore as the source of the most common form of ovarian cancer, researchers and clinicians are devising strategies to prevent the disease. https:\/\/media.nature.com\/original\/magazine-assets\/d41586-021-03717-7\/d41586-021-03717-7.pdf<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Germline pathogenic variants in BRCA1 or BRCA2 genes increase the risk of ovarian high grade serous carcinoma, the most common and most lethal subtype of epithelial ovarian cancer. Carriers of these genetic variants are usually offered surgery known as risk-reducing salpingo-oophorectomy (RRSO) where the Fallopian tubes and ovaries are removed. We report the case of […]<\/p>\n

Read More…<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1696","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"\nLong term dormancy in a BRCA1 heterozygote (Contributed by Drs. Setor Amuzu, Lili Fu, and William D Foulkes) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2022\/01\/17\/long-term-dormancy-in-a-brca1-heterozygote\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Long term dormancy in a BRCA1 heterozygote (Contributed by Drs. Setor Amuzu, Lili Fu, and William D Foulkes) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Germline pathogenic variants in BRCA1 or BRCA2 genes increase the risk of ovarian high grade serous carcinoma, the most common and most lethal subtype of epithelial ovarian cancer. Carriers of these genetic variants are usually offered surgery known as risk-reducing salpingo-oophorectomy (RRSO) where the Fallopian tubes and ovaries are removed. We report the case of [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2022\/01\/17\/long-term-dormancy-in-a-brca1-heterozygote\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2022-01-17T20:23:23+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-23T01:06:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/blogs.bmj.com\/jmg\/files\/2022\/01\/Corrected-Picture-for-JMG-Blog-scaled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2560\" \/>\n\t<meta property=\"og:image:height\" content=\"1920\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2022\\\/01\\\/17\\\/long-term-dormancy-in-a-brca1-heterozygote\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2022\\\/01\\\/17\\\/long-term-dormancy-in-a-brca1-heterozygote\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Long term dormancy in a BRCA1 heterozygote (Contributed by Drs. 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