{"id":1589,"date":"2020-12-22T01:21:41","date_gmt":"2020-12-22T01:21:41","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=1589"},"modified":"2026-02-23T23:10:41","modified_gmt":"2026-02-23T23:10:41","slug":"calibration-of-polygenic-risk-scores-is-required-prior-to-clinical-implementation-results-of-three-common-cancers-in-ukb","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2020\/12\/22\/calibration-of-polygenic-risk-scores-is-required-prior-to-clinical-implementation-results-of-three-common-cancers-in-ukb\/","title":{"rendered":"Calibration of polygenic risk scores is required prior to clinical implementation: results of three common cancers in UKB (Contributed by W Kyle Resurreccion)"},"content":{"rendered":"<p>Studies have shown a consistent trend between polygenic risk score percentiles and disease risk in populations, and this evidence is used to support its clinical use. However, in clinic, polygenic risk score values, not percentiles, are used for estimating disease lifetime risk. In this study, we assessed the calibration of polygenic risk score values for three common cancers (prostate, breast and colorectal) by comparing them with the respective observed risks in the large UK Biobank population. A systematic bias was found for each cancer. This bias, however, can be corrected using a scaling approach. We conclude that calibration is necessary and feasible prior to clinical implementation. (<a href=\"https:\/\/jmg.bmj.com\/content\/early\/2020\/12\/20\/jmedgenet-2020-107286\">https:\/\/jmg.bmj.com\/content\/early\/2020\/12\/20\/jmedgenet-2020-107286<\/a> )<\/p>\n<p><a href=\"https:\/\/blogs.bmj.com\/jmg\/2020\/12\/22\/calibration-of-polygenic-risk-scores-is-required-prior-to-clinical-implementation-results-of-three-common-cancers-in-ukb\/imagea4126d\/\" rel=\"attachment wp-att-1590\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-1590\" src=\"https:\/\/blogs.bmj.com\/jmg\/files\/2020\/12\/imagea4126d.png\" alt=\"\" width=\"180\" height=\"34\" \/><\/a><\/p>\n<p>&nbsp;<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Studies have shown a consistent trend between polygenic risk score percentiles and disease risk in populations, and this evidence is used to support its clinical use. However, in clinic, polygenic risk score values, not percentiles, are used for estimating disease lifetime risk. In this study, we assessed the calibration of polygenic risk score values for [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2020\/12\/22\/calibration-of-polygenic-risk-scores-is-required-prior-to-clinical-implementation-results-of-three-common-cancers-in-ukb\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1589","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Calibration of polygenic risk scores is required prior to clinical implementation: results of three common cancers in UKB (Contributed by W Kyle Resurreccion) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2020\/12\/22\/calibration-of-polygenic-risk-scores-is-required-prior-to-clinical-implementation-results-of-three-common-cancers-in-ukb\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Calibration of polygenic risk scores is required prior to clinical implementation: results of three common cancers in UKB (Contributed by W Kyle Resurreccion) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Studies have shown a consistent trend between polygenic risk score percentiles and disease risk in populations, and this evidence is used to support its clinical use. However, in clinic, polygenic risk score values, not percentiles, are used for estimating disease lifetime risk. In this study, we assessed the calibration of polygenic risk score values for [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2020\/12\/22\/calibration-of-polygenic-risk-scores-is-required-prior-to-clinical-implementation-results-of-three-common-cancers-in-ukb\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2020-12-22T01:21:41+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-23T23:10:41+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/blogs.bmj.com\/jmg\/files\/2020\/12\/imagea4126d.png\" \/>\n\t<meta property=\"og:image:width\" content=\"180\" \/>\n\t<meta property=\"og:image:height\" content=\"34\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/12\\\/22\\\/calibration-of-polygenic-risk-scores-is-required-prior-to-clinical-implementation-results-of-three-common-cancers-in-ukb\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/12\\\/22\\\/calibration-of-polygenic-risk-scores-is-required-prior-to-clinical-implementation-results-of-three-common-cancers-in-ukb\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Calibration of polygenic risk scores is required prior to clinical implementation: results of three common cancers in UKB (Contributed by W Kyle Resurreccion)\",\"datePublished\":\"2020-12-22T01:21:41+00:00\",\"dateModified\":\"2026-02-23T23:10:41+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/12\\\/22\\\/calibration-of-polygenic-risk-scores-is-required-prior-to-clinical-implementation-results-of-three-common-cancers-in-ukb\\\/\"},\"wordCount\":138,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/12\\\/22\\\/calibration-of-polygenic-risk-scores-is-required-prior-to-clinical-implementation-results-of-three-common-cancers-in-ukb\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2020\\\/12\\\/imagea4126d.png\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/12\\\/22\\\/calibration-of-polygenic-risk-scores-is-required-prior-to-clinical-implementation-results-of-three-common-cancers-in-ukb\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/12\\\/22\\\/calibration-of-polygenic-risk-scores-is-required-prior-to-clinical-implementation-results-of-three-common-cancers-in-ukb\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/12\\\/22\\\/calibration-of-polygenic-risk-scores-is-required-prior-to-clinical-implementation-results-of-three-common-cancers-in-ukb\\\/\",\"name\":\"Calibration of polygenic risk scores is required prior to clinical implementation: results of three common cancers in UKB (Contributed by W Kyle Resurreccion) - 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His research applies human genetics and multi-omics to complex and pediatric diseases, including GWAS, polygenic risk scores (PRS), single-cell transcriptomics, and integrative genomics to support precision medicine and clinical translation.\",\"sameAs\":[\"https:\\\/\\\/x.com\\\/HuiQiQu\"],\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/author\\\/hqiqu\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Calibration of polygenic risk scores is required prior to clinical implementation: results of three common cancers in UKB (Contributed by W Kyle Resurreccion) - JMG Contact blog","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/blogs.bmj.com\/jmg\/2020\/12\/22\/calibration-of-polygenic-risk-scores-is-required-prior-to-clinical-implementation-results-of-three-common-cancers-in-ukb\/","og_locale":"en_US","og_type":"article","og_title":"Calibration of polygenic risk scores is required prior to clinical implementation: results of three common cancers in UKB (Contributed by W Kyle Resurreccion) - JMG Contact blog","og_description":"Studies have shown a consistent trend between polygenic risk score percentiles and disease risk in populations, and this evidence is used to support its clinical use. 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