{"id":1584,"date":"2020-12-15T20:09:01","date_gmt":"2020-12-15T20:09:01","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=1584"},"modified":"2026-02-23T23:12:07","modified_gmt":"2026-02-23T23:12:07","slug":"dysfunction-of-vipr2-leads-to-myopia-in-humans-and-mice","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2020\/12\/15\/dysfunction-of-vipr2-leads-to-myopia-in-humans-and-mice\/","title":{"rendered":"Dysfunction of VIPR2 leads to myopia in humans and mice (Contributed by Dr.\u00a0Xiangtian\u00a0Zhou)"},"content":{"rendered":"

Myopia incidence is reaching epidemic proportions in some communities, especially in East Asia regions. Meta-association analysis was used to determine if the vasoactive intestinal peptide receptor 2 (VIPR2<\/em>) associated with myopia a human Chinese cohort, and then conform it using Vipr2<\/em>-KO mice. Presence of variant in the VIPR2<\/em> gene and loss of VIPR2 function in mice promoted increases in myopia progression. Functional evidences suggested that VIPR2 dysfunction affecting the bipolar cell function, resulting in abnormal retinal electrical wave activity output, then give rise to myopia. VIP-VIPR2 signaling axis may provide a novel target to improve therapeutic management of this condition. (https:\/\/jmg.bmj.com\/content\/early\/2020\/12\/14\/jmedgenet-2020-107220<\/a> )<\/p>\n","protected":false},"excerpt":{"rendered":"

Myopia incidence is reaching epidemic proportions in some communities, especially in East Asia regions. Meta-association analysis was used to determine if the vasoactive intestinal peptide receptor 2 (VIPR2) associated with myopia a human Chinese cohort, and then conform it using Vipr2-KO mice. Presence of variant in the VIPR2 gene and loss of VIPR2 function in […]<\/p>\n

Read More…<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1584","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"\nDysfunction of VIPR2 leads to myopia in humans and mice (Contributed by Dr.\u00a0Xiangtian\u00a0Zhou) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2020\/12\/15\/dysfunction-of-vipr2-leads-to-myopia-in-humans-and-mice\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dysfunction of VIPR2 leads to myopia in humans and mice (Contributed by Dr.\u00a0Xiangtian\u00a0Zhou) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Myopia incidence is reaching epidemic proportions in some communities, especially in East Asia regions. Meta-association analysis was used to determine if the vasoactive intestinal peptide receptor 2 (VIPR2) associated with myopia a human Chinese cohort, and then conform it using Vipr2-KO mice. Presence of variant in the VIPR2 gene and loss of VIPR2 function in [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2020\/12\/15\/dysfunction-of-vipr2-leads-to-myopia-in-humans-and-mice\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2020-12-15T20:09:01+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-23T23:12:07+00:00\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/12\\\/15\\\/dysfunction-of-vipr2-leads-to-myopia-in-humans-and-mice\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/12\\\/15\\\/dysfunction-of-vipr2-leads-to-myopia-in-humans-and-mice\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Dysfunction of VIPR2 leads to myopia in humans and mice (Contributed by Dr.\u00a0Xiangtian\u00a0Zhou)\",\"datePublished\":\"2020-12-15T20:09:01+00:00\",\"dateModified\":\"2026-02-23T23:12:07+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/12\\\/15\\\/dysfunction-of-vipr2-leads-to-myopia-in-humans-and-mice\\\/\"},\"wordCount\":123,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/12\\\/15\\\/dysfunction-of-vipr2-leads-to-myopia-in-humans-and-mice\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/12\\\/15\\\/dysfunction-of-vipr2-leads-to-myopia-in-humans-and-mice\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/12\\\/15\\\/dysfunction-of-vipr2-leads-to-myopia-in-humans-and-mice\\\/\",\"name\":\"Dysfunction of VIPR2 leads to myopia in humans and mice (Contributed by Dr.\u00a0Xiangtian\u00a0Zhou) - JMG Contact blog\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#website\"},\"datePublished\":\"2020-12-15T20:09:01+00:00\",\"dateModified\":\"2026-02-23T23:12:07+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/12\\\/15\\\/dysfunction-of-vipr2-leads-to-myopia-in-humans-and-mice\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/12\\\/15\\\/dysfunction-of-vipr2-leads-to-myopia-in-humans-and-mice\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/12\\\/15\\\/dysfunction-of-vipr2-leads-to-myopia-in-humans-and-mice\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Dysfunction of VIPR2 leads to myopia in humans and mice (Contributed by Dr.\u00a0Xiangtian\u00a0Zhou)\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#website\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/\",\"name\":\"JMG Contact blog\",\"description\":\"JMG Contact blog\",\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\",\"name\":\"JMG Contact blog\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2017\\\/10\\\/blog-logo-jmg.png\",\"contentUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2017\\\/10\\\/blog-logo-jmg.png\",\"width\":300,\"height\":34,\"caption\":\"JMG Contact blog\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\",\"name\":\"hqqu\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g\",\"caption\":\"hqqu\"},\"description\":\"Huiqi Qu has a background as a physician trained in internal medicine and a PhD in Experimental Medicine (Endocrinology). His research applies human genetics and multi-omics to complex and pediatric diseases, including GWAS, polygenic risk scores (PRS), single-cell transcriptomics, and integrative genomics to support precision medicine and clinical translation.\",\"sameAs\":[\"https:\\\/\\\/x.com\\\/HuiQiQu\"],\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/author\\\/hqiqu\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Dysfunction of VIPR2 leads to myopia in humans and mice (Contributed by Dr.\u00a0Xiangtian\u00a0Zhou) - JMG Contact blog","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/blogs.bmj.com\/jmg\/2020\/12\/15\/dysfunction-of-vipr2-leads-to-myopia-in-humans-and-mice\/","og_locale":"en_US","og_type":"article","og_title":"Dysfunction of VIPR2 leads to myopia in humans and mice (Contributed by Dr.\u00a0Xiangtian\u00a0Zhou) - JMG Contact blog","og_description":"Myopia incidence is reaching epidemic proportions in some communities, especially in East Asia regions. Meta-association analysis was used to determine if the vasoactive intestinal peptide receptor 2 (VIPR2) associated with myopia a human Chinese cohort, and then conform it using Vipr2-KO mice. Presence of variant in the VIPR2 gene and loss of VIPR2 function in [...]Read More...","og_url":"https:\/\/blogs.bmj.com\/jmg\/2020\/12\/15\/dysfunction-of-vipr2-leads-to-myopia-in-humans-and-mice\/","og_site_name":"JMG Contact blog","article_published_time":"2020-12-15T20:09:01+00:00","article_modified_time":"2026-02-23T23:12:07+00:00","author":"hqqu","twitter_card":"summary_large_image","twitter_creator":"@HuiQiQu","twitter_misc":{"Written by":"hqqu","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/blogs.bmj.com\/jmg\/2020\/12\/15\/dysfunction-of-vipr2-leads-to-myopia-in-humans-and-mice\/#article","isPartOf":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2020\/12\/15\/dysfunction-of-vipr2-leads-to-myopia-in-humans-and-mice\/"},"author":{"name":"hqqu","@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/person\/be0250f8d5b52412c3e7c222dabd591b"},"headline":"Dysfunction of VIPR2 leads to myopia in humans and mice (Contributed by Dr.\u00a0Xiangtian\u00a0Zhou)","datePublished":"2020-12-15T20:09:01+00:00","dateModified":"2026-02-23T23:12:07+00:00","mainEntityOfPage":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2020\/12\/15\/dysfunction-of-vipr2-leads-to-myopia-in-humans-and-mice\/"},"wordCount":123,"commentCount":0,"publisher":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#organization"},"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/blogs.bmj.com\/jmg\/2020\/12\/15\/dysfunction-of-vipr2-leads-to-myopia-in-humans-and-mice\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/blogs.bmj.com\/jmg\/2020\/12\/15\/dysfunction-of-vipr2-leads-to-myopia-in-humans-and-mice\/","url":"https:\/\/blogs.bmj.com\/jmg\/2020\/12\/15\/dysfunction-of-vipr2-leads-to-myopia-in-humans-and-mice\/","name":"Dysfunction of VIPR2 leads to myopia in humans and mice (Contributed by Dr.\u00a0Xiangtian\u00a0Zhou) - JMG Contact blog","isPartOf":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#website"},"datePublished":"2020-12-15T20:09:01+00:00","dateModified":"2026-02-23T23:12:07+00:00","breadcrumb":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2020\/12\/15\/dysfunction-of-vipr2-leads-to-myopia-in-humans-and-mice\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/blogs.bmj.com\/jmg\/2020\/12\/15\/dysfunction-of-vipr2-leads-to-myopia-in-humans-and-mice\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/blogs.bmj.com\/jmg\/2020\/12\/15\/dysfunction-of-vipr2-leads-to-myopia-in-humans-and-mice\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/blogs.bmj.com\/jmg\/"},{"@type":"ListItem","position":2,"name":"Dysfunction of VIPR2 leads to myopia in humans and mice (Contributed by Dr.\u00a0Xiangtian\u00a0Zhou)"}]},{"@type":"WebSite","@id":"https:\/\/blogs.bmj.com\/jmg\/#website","url":"https:\/\/blogs.bmj.com\/jmg\/","name":"JMG Contact blog","description":"JMG Contact blog","publisher":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/blogs.bmj.com\/jmg\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/blogs.bmj.com\/jmg\/#organization","name":"JMG Contact blog","url":"https:\/\/blogs.bmj.com\/jmg\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/logo\/image\/","url":"https:\/\/blogs.bmj.com\/jmg\/files\/2017\/10\/blog-logo-jmg.png","contentUrl":"https:\/\/blogs.bmj.com\/jmg\/files\/2017\/10\/blog-logo-jmg.png","width":300,"height":34,"caption":"JMG Contact blog"},"image":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/person\/be0250f8d5b52412c3e7c222dabd591b","name":"hqqu","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g","caption":"hqqu"},"description":"Huiqi Qu has a background as a physician trained in internal medicine and a PhD in Experimental Medicine (Endocrinology). His research applies human genetics and multi-omics to complex and pediatric diseases, including GWAS, polygenic risk scores (PRS), single-cell transcriptomics, and integrative genomics to support precision medicine and clinical translation.","sameAs":["https:\/\/x.com\/HuiQiQu"],"url":"https:\/\/blogs.bmj.com\/jmg\/author\/hqiqu\/"}]}},"_links":{"self":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/1584","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/users\/123"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/comments?post=1584"}],"version-history":[{"count":0,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/1584\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/media?parent=1584"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/categories?post=1584"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/tags?post=1584"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}