{"id":1550,"date":"2020-09-24T17:21:10","date_gmt":"2020-09-24T17:21:10","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=1550"},"modified":"2026-02-23T23:39:21","modified_gmt":"2026-02-23T23:39:21","slug":"biallelic-variant-in-cyclin-b3-is-associated-with-failure-of-maternal-meiosis-ii-and-recurrent-digynic-triploidy-2","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2020\/09\/24\/biallelic-variant-in-cyclin-b3-is-associated-with-failure-of-maternal-meiosis-ii-and-recurrent-digynic-triploidy-2\/","title":{"rendered":"Biallelic variant in cyclin B3 is associated with failure of maternal meiosis II and recurrent digynic triploidy (Contributed by Dr. Andrea Riccio)"},"content":{"rendered":"<p>Fetus triploidy is a common cause of early miscarriages. In some cases, genetic predisposition has been suspected, but the genes involved are unknown. Here we explored the genetic cause of recurrent pregnancy loss associated with fetus triploidy in an Iranian family. We found a mutation in the cyclin B3 gene that is normally required to complete meiosis in oocytes. The mutation affects chromosome segregation, resulting in abnormal oocytes and fetus triploidy. Our results implicate a rationale for testing the cyclin B3 gene in recurrent pregnancy loss. (<a href=\"https:\/\/jmg.bmj.com\/content\/early\/2020\/09\/16\/jmedgenet-2020-106909\">https:\/\/jmg.bmj.com\/content\/early\/2020\/09\/16\/jmedgenet-2020-106909<\/a> )<\/p>\n<p>&nbsp;<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Fetus triploidy is a common cause of early miscarriages. In some cases, genetic predisposition has been suspected, but the genes involved are unknown. Here we explored the genetic cause of recurrent pregnancy loss associated with fetus triploidy in an Iranian family. We found a mutation in the cyclin B3 gene that is normally required to [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2020\/09\/24\/biallelic-variant-in-cyclin-b3-is-associated-with-failure-of-maternal-meiosis-ii-and-recurrent-digynic-triploidy-2\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1550","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Biallelic variant in cyclin B3 is associated with failure of maternal meiosis II and recurrent digynic triploidy (Contributed by Dr. Andrea Riccio) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2020\/09\/24\/biallelic-variant-in-cyclin-b3-is-associated-with-failure-of-maternal-meiosis-ii-and-recurrent-digynic-triploidy-2\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Biallelic variant in cyclin B3 is associated with failure of maternal meiosis II and recurrent digynic triploidy (Contributed by Dr. Andrea Riccio) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Fetus triploidy is a common cause of early miscarriages. In some cases, genetic predisposition has been suspected, but the genes involved are unknown. Here we explored the genetic cause of recurrent pregnancy loss associated with fetus triploidy in an Iranian family. We found a mutation in the cyclin B3 gene that is normally required to [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2020\/09\/24\/biallelic-variant-in-cyclin-b3-is-associated-with-failure-of-maternal-meiosis-ii-and-recurrent-digynic-triploidy-2\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2020-09-24T17:21:10+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-23T23:39:21+00:00\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/09\\\/24\\\/biallelic-variant-in-cyclin-b3-is-associated-with-failure-of-maternal-meiosis-ii-and-recurrent-digynic-triploidy-2\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/09\\\/24\\\/biallelic-variant-in-cyclin-b3-is-associated-with-failure-of-maternal-meiosis-ii-and-recurrent-digynic-triploidy-2\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Biallelic variant in cyclin B3 is associated with failure of maternal meiosis II and recurrent digynic triploidy (Contributed by Dr. Andrea Riccio)\",\"datePublished\":\"2020-09-24T17:21:10+00:00\",\"dateModified\":\"2026-02-23T23:39:21+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/09\\\/24\\\/biallelic-variant-in-cyclin-b3-is-associated-with-failure-of-maternal-meiosis-ii-and-recurrent-digynic-triploidy-2\\\/\"},\"wordCount\":117,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/09\\\/24\\\/biallelic-variant-in-cyclin-b3-is-associated-with-failure-of-maternal-meiosis-ii-and-recurrent-digynic-triploidy-2\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/09\\\/24\\\/biallelic-variant-in-cyclin-b3-is-associated-with-failure-of-maternal-meiosis-ii-and-recurrent-digynic-triploidy-2\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/09\\\/24\\\/biallelic-variant-in-cyclin-b3-is-associated-with-failure-of-maternal-meiosis-ii-and-recurrent-digynic-triploidy-2\\\/\",\"name\":\"Biallelic variant in cyclin B3 is associated with failure of maternal meiosis II and recurrent digynic triploidy (Contributed by Dr. Andrea Riccio) - 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