{"id":1518,"date":"2020-08-18T02:57:18","date_gmt":"2020-08-18T02:57:18","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=1518"},"modified":"2026-02-23T23:50:23","modified_gmt":"2026-02-23T23:50:23","slug":"can-population-brca-screening-be-applied-in-non-ashkenazi-jewish-populations-experience-in-macau-population","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2020\/08\/18\/can-population-brca-screening-be-applied-in-non-ashkenazi-jewish-populations-experience-in-macau-population\/","title":{"rendered":"Can population BRCA screening be applied in non-Ashkenazi Jewish populations? Experience in Macau population (Contributed by Dr. San Ming Wang)"},"content":{"rendered":"<p>BRCA mutation increases risk of breast and ovarian cancer. Identifying the mutation carriers is the first step to prevent the mutation-caused cancer. Population screening can reach comprehensive identification of the mutation carriers to prevent the cancer. However, this approach is considered only suitable for Ashkenazi Jewish population with high-frequent founder mutations, but not suitable for other populations with lower mutation frequency due to higher testing cost. We used population screening in 6,000 Macau individuals, and successfully identified the BRCA mutation carriers at reasonable cost. Our study shows that that cost can only be one of the many factors and population screening can be applied in non-Jewish populations. (<a href=\"https:\/\/jmg.bmj.com\/content\/early\/2020\/08\/17\/jmedgenet-2020-107181\">https:\/\/jmg.bmj.com\/content\/early\/2020\/08\/17\/jmedgenet-2020-107181<\/a> )<\/p>\n<p><a href=\"https:\/\/blogs.bmj.com\/jmg\/2020\/08\/18\/can-population-brca-screening-be-applied-in-non-ashkenazi-jewish-populations-experience-in-macau-population\/macau-map\/\" rel=\"attachment wp-att-1519\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-1519\" src=\"https:\/\/blogs.bmj.com\/jmg\/files\/2020\/08\/Macau-map-300x219.png\" alt=\"\" width=\"300\" height=\"219\" srcset=\"https:\/\/blogs.bmj.com\/jmg\/files\/2020\/08\/Macau-map-300x219.png 300w, https:\/\/blogs.bmj.com\/jmg\/files\/2020\/08\/Macau-map-1024x747.png 1024w, https:\/\/blogs.bmj.com\/jmg\/files\/2020\/08\/Macau-map-768x560.png 768w, https:\/\/blogs.bmj.com\/jmg\/files\/2020\/08\/Macau-map-1536x1120.png 1536w, https:\/\/blogs.bmj.com\/jmg\/files\/2020\/08\/Macau-map-640x467.png 640w, https:\/\/blogs.bmj.com\/jmg\/files\/2020\/08\/Macau-map.png 1558w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>BRCA mutation increases risk of breast and ovarian cancer. Identifying the mutation carriers is the first step to prevent the mutation-caused cancer. Population screening can reach comprehensive identification of the mutation carriers to prevent the cancer. However, this approach is considered only suitable for Ashkenazi Jewish population with high-frequent founder mutations, but not suitable for [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2020\/08\/18\/can-population-brca-screening-be-applied-in-non-ashkenazi-jewish-populations-experience-in-macau-population\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1518","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Can population BRCA screening be applied in non-Ashkenazi Jewish populations? Experience in Macau population (Contributed by Dr. San Ming Wang) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2020\/08\/18\/can-population-brca-screening-be-applied-in-non-ashkenazi-jewish-populations-experience-in-macau-population\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Can population BRCA screening be applied in non-Ashkenazi Jewish populations? Experience in Macau population (Contributed by Dr. San Ming Wang) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"BRCA mutation increases risk of breast and ovarian cancer. Identifying the mutation carriers is the first step to prevent the mutation-caused cancer. Population screening can reach comprehensive identification of the mutation carriers to prevent the cancer. However, this approach is considered only suitable for Ashkenazi Jewish population with high-frequent founder mutations, but not suitable for [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2020\/08\/18\/can-population-brca-screening-be-applied-in-non-ashkenazi-jewish-populations-experience-in-macau-population\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2020-08-18T02:57:18+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-23T23:50:23+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/blogs.bmj.com\/jmg\/files\/2020\/08\/Macau-map-1024x747.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"747\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/08\\\/18\\\/can-population-brca-screening-be-applied-in-non-ashkenazi-jewish-populations-experience-in-macau-population\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/08\\\/18\\\/can-population-brca-screening-be-applied-in-non-ashkenazi-jewish-populations-experience-in-macau-population\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Can population BRCA screening be applied in non-Ashkenazi Jewish populations? 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