{"id":151,"date":"2011-05-27T18:34:11","date_gmt":"2011-05-27T18:34:11","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=151"},"modified":"2026-02-25T21:09:14","modified_gmt":"2026-02-25T21:09:14","slug":"chromosomes-do-it-by-halves","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2011\/05\/27\/chromosomes-do-it-by-halves\/","title":{"rendered":"Chromosomes do it by halves (Contributed by Darren K Griffin, PhD, DSc, FIBiol, FRCPath)"},"content":{"rendered":"

Extra\/missing chromosomes are the leading cause of mental retardation, pregnancy loss and IVF failure.\u00a0 Most arise in the egg however the mechanism by which errors occur is under debate.\u00a0 Normally, each chromosome of a pair migrates to opposite cell poles before cell division (disjunction); the textbook dogma suggests that errors occur when two chromosomes migrate to the same pole (nondisjunction). Angell and colleagues however proposed that, in fact, errors occurred when 1.5 chromosomes migrate to one pole and half a chromosome (chromatid) migrates to the other<\/strong> (precocious separation).\u00a0 This model was widely respected, but not universally accepted, as critics purported that the observations could be down to technical artefacts.\u00a0 Here we revisited this model using microarray technology and found that precocious separation is over 15 times more common than non-disjunction. (http:\/\/jmg.bmj.com\/content\/early\/2011\/05\/26\/jmg.2010.088070.abstract?papetoc<\/a> )<\/p>\n","protected":false},"excerpt":{"rendered":"

Extra\/missing chromosomes are the leading cause of mental retardation, pregnancy loss and IVF failure.\u00a0 Most arise in the egg however the mechanism by which errors occur is under debate.\u00a0 Normally, each chromosome of a pair migrates to opposite cell poles before cell division (disjunction); the textbook dogma suggests that errors occur when two chromosomes migrate […]<\/p>\n

Read More…<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-151","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"\nChromosomes do it by halves (Contributed by Darren K Griffin, PhD, DSc, FIBiol, FRCPath) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2011\/05\/27\/chromosomes-do-it-by-halves\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Chromosomes do it by halves (Contributed by Darren K Griffin, PhD, DSc, FIBiol, FRCPath) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Extra\/missing chromosomes are the leading cause of mental retardation, pregnancy loss and IVF failure.\u00a0 Most arise in the egg however the mechanism by which errors occur is under debate.\u00a0 Normally, each chromosome of a pair migrates to opposite cell poles before cell division (disjunction); the textbook dogma suggests that errors occur when two chromosomes migrate [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2011\/05\/27\/chromosomes-do-it-by-halves\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2011-05-27T18:34:11+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-25T21:09:14+00:00\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2011\\\/05\\\/27\\\/chromosomes-do-it-by-halves\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2011\\\/05\\\/27\\\/chromosomes-do-it-by-halves\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Chromosomes do it by halves (Contributed by Darren K Griffin, PhD, DSc, FIBiol, FRCPath)\",\"datePublished\":\"2011-05-27T18:34:11+00:00\",\"dateModified\":\"2026-02-25T21:09:14+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2011\\\/05\\\/27\\\/chromosomes-do-it-by-halves\\\/\"},\"wordCount\":152,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2011\\\/05\\\/27\\\/chromosomes-do-it-by-halves\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2011\\\/05\\\/27\\\/chromosomes-do-it-by-halves\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2011\\\/05\\\/27\\\/chromosomes-do-it-by-halves\\\/\",\"name\":\"Chromosomes do it by halves (Contributed by Darren K Griffin, PhD, DSc, FIBiol, FRCPath) - 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