{"id":1490,"date":"2020-06-24T16:47:28","date_gmt":"2020-06-24T16:47:28","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=1490"},"modified":"2026-02-23T23:55:54","modified_gmt":"2026-02-23T23:55:54","slug":"loss-of-imprinting-of-the-human-specific-imprinted-gene-znf597-causes-prenatal-growth-retardation-and-dysmorphic-features-implications-for-phenotypic-overlap-with-silver-russell-syndrome","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2020\/06\/24\/loss-of-imprinting-of-the-human-specific-imprinted-gene-znf597-causes-prenatal-growth-retardation-and-dysmorphic-features-implications-for-phenotypic-overlap-with-silver-russell-syndrome\/","title":{"rendered":"Loss of imprinting of the human-specific imprinted gene ZNF597 causes prenatal growth retardation and dysmorphic features: implications for phenotypic overlap with Silver-Russell syndrome (Contributed by Dr. Kazuki Yamazawa)"},"content":{"rendered":"

Various kinds of genetic and epigenetic changes can cause growth failure before and after birth. Through screening of a cohort of babies born small for gestational age, we have encountered a 6-year-old boy with prenatal growth restriction and some specific physical features. Detailed molecular analyses have revealed epigenetic alteration (epimutation) of the ZNF597 gene on chromosome 16. This is the first report describing the possible relationship between the ZNF597 gene and growth failure in children. (Epi)genetic test for ZNF597 may be worth considering for small babies of unknown etiology. (https:\/\/jmg.bmj.com\/content\/early\/2020\/06\/23\/jmedgenet-2020-107019<\/a> )<\/p>\n

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Various kinds of genetic and epigenetic changes can cause growth failure before and after birth. Through screening of a cohort of babies born small for gestational age, we have encountered a 6-year-old boy with prenatal growth restriction and some specific physical features. Detailed molecular analyses have revealed epigenetic alteration (epimutation) of the ZNF597 gene on […]<\/p>\n

Read More…<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1490","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"\nLoss of imprinting of the human-specific imprinted gene ZNF597 causes prenatal growth retardation and dysmorphic features: implications for phenotypic overlap with Silver-Russell syndrome (Contributed by Dr. Kazuki Yamazawa) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2020\/06\/24\/loss-of-imprinting-of-the-human-specific-imprinted-gene-znf597-causes-prenatal-growth-retardation-and-dysmorphic-features-implications-for-phenotypic-overlap-with-silver-russell-syndrome\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Loss of imprinting of the human-specific imprinted gene ZNF597 causes prenatal growth retardation and dysmorphic features: implications for phenotypic overlap with Silver-Russell syndrome (Contributed by Dr. Kazuki Yamazawa) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Various kinds of genetic and epigenetic changes can cause growth failure before and after birth. Through screening of a cohort of babies born small for gestational age, we have encountered a 6-year-old boy with prenatal growth restriction and some specific physical features. 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