{"id":1461,"date":"2020-05-22T02:46:34","date_gmt":"2020-05-22T02:46:34","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=1461"},"modified":"2026-02-24T00:04:04","modified_gmt":"2026-02-24T00:04:04","slug":"a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2020\/05\/22\/a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features\/","title":{"rendered":"A component of MICOS (APOO\/MIC26) associated with a new X-linked mitochondrial myopathy, lactic acidosis, cognitive impairment and autistic features (Contributed by Dr. Cristiane Beninc\u00e1)"},"content":{"rendered":"<p>Researchers from UK, Brazil and Italy identified the first family with a syndrome due to a mutation in <em>APOO<\/em> encoding MIC26, a component of the Mitochondrial Contact Site and Cristae Organizing System (MICOS). MICOS is considered the \u201cmitoskeleton\u201d, organizing the organelle cristae. The pathogenic change in MIC26 hits the hydrophobic region of the protein, compromising its processing and binding to the mitochondrial inner membrane, with consequent impairment of the cristae architecture and oxidative phosphorylation, an essential bioenergetic pathway carried out by the respiratory complexes within the mitochondrial cristae. (<a href=\"https:\/\/jmg.bmj.com\/content\/early\/2020\/05\/21\/jmedgenet-2020-106861\">https:\/\/jmg.bmj.com\/content\/early\/2020\/05\/21\/jmedgenet-2020-106861<\/a> )<\/p>\n<p><a href=\"https:\/\/blogs.bmj.com\/jmg\/2020\/05\/22\/a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features\/apoo_scheme\/\" rel=\"attachment wp-att-1462\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-1462\" src=\"https:\/\/blogs.bmj.com\/jmg\/files\/2020\/05\/APOO_Scheme-300x248.png\" alt=\"\" width=\"300\" height=\"248\" srcset=\"https:\/\/blogs.bmj.com\/jmg\/files\/2020\/05\/APOO_Scheme-300x248.png 300w, https:\/\/blogs.bmj.com\/jmg\/files\/2020\/05\/APOO_Scheme-1024x848.png 1024w, https:\/\/blogs.bmj.com\/jmg\/files\/2020\/05\/APOO_Scheme-768x636.png 768w, https:\/\/blogs.bmj.com\/jmg\/files\/2020\/05\/APOO_Scheme-640x530.png 640w, https:\/\/blogs.bmj.com\/jmg\/files\/2020\/05\/APOO_Scheme.png 1520w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>&nbsp;<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Researchers from UK, Brazil and Italy identified the first family with a syndrome due to a mutation in APOO encoding MIC26, a component of the Mitochondrial Contact Site and Cristae Organizing System (MICOS). MICOS is considered the \u201cmitoskeleton\u201d, organizing the organelle cristae. The pathogenic change in MIC26 hits the hydrophobic region of the protein, compromising [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2020\/05\/22\/a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1461","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>A component of MICOS (APOO\/MIC26) associated with a new X-linked mitochondrial myopathy, lactic acidosis, cognitive impairment and autistic features (Contributed by Dr. Cristiane Beninc\u00e1) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2020\/05\/22\/a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A component of MICOS (APOO\/MIC26) associated with a new X-linked mitochondrial myopathy, lactic acidosis, cognitive impairment and autistic features (Contributed by Dr. Cristiane Beninc\u00e1) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Researchers from UK, Brazil and Italy identified the first family with a syndrome due to a mutation in APOO encoding MIC26, a component of the Mitochondrial Contact Site and Cristae Organizing System (MICOS). MICOS is considered the \u201cmitoskeleton\u201d, organizing the organelle cristae. The pathogenic change in MIC26 hits the hydrophobic region of the protein, compromising [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2020\/05\/22\/a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2020-05-22T02:46:34+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-24T00:04:04+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/blogs.bmj.com\/jmg\/files\/2020\/05\/APOO_Scheme.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1520\" \/>\n\t<meta property=\"og:image:height\" content=\"1259\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/05\\\/22\\\/a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/05\\\/22\\\/a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"A component of MICOS (APOO\\\/MIC26) associated with a new X-linked mitochondrial myopathy, lactic acidosis, cognitive impairment and autistic features (Contributed by Dr. Cristiane Beninc\u00e1)\",\"datePublished\":\"2020-05-22T02:46:34+00:00\",\"dateModified\":\"2026-02-24T00:04:04+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/05\\\/22\\\/a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features\\\/\"},\"wordCount\":122,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/05\\\/22\\\/a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2020\\\/05\\\/APOO_Scheme-300x248.png\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/05\\\/22\\\/a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/05\\\/22\\\/a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/05\\\/22\\\/a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features\\\/\",\"name\":\"A component of MICOS (APOO\\\/MIC26) associated with a new X-linked mitochondrial myopathy, lactic acidosis, cognitive impairment and autistic features (Contributed by Dr. Cristiane Beninc\u00e1) - JMG Contact blog\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/05\\\/22\\\/a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/05\\\/22\\\/a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2020\\\/05\\\/APOO_Scheme-300x248.png\",\"datePublished\":\"2020-05-22T02:46:34+00:00\",\"dateModified\":\"2026-02-24T00:04:04+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/05\\\/22\\\/a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/05\\\/22\\\/a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/05\\\/22\\\/a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features\\\/#primaryimage\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2020\\\/05\\\/APOO_Scheme.png\",\"contentUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2020\\\/05\\\/APOO_Scheme.png\",\"width\":1520,\"height\":1259},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/05\\\/22\\\/a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"A component of MICOS (APOO\\\/MIC26) associated with a new X-linked mitochondrial myopathy, lactic acidosis, cognitive impairment and autistic features (Contributed by Dr. Cristiane Beninc\u00e1)\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#website\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/\",\"name\":\"JMG Contact blog\",\"description\":\"JMG Contact blog\",\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\",\"name\":\"JMG Contact blog\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2017\\\/10\\\/blog-logo-jmg.png\",\"contentUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2017\\\/10\\\/blog-logo-jmg.png\",\"width\":300,\"height\":34,\"caption\":\"JMG Contact blog\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\",\"name\":\"hqqu\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g\",\"caption\":\"hqqu\"},\"description\":\"Huiqi Qu has a background as a physician trained in internal medicine and a PhD in Experimental Medicine (Endocrinology). His research applies human genetics and multi-omics to complex and pediatric diseases, including GWAS, polygenic risk scores (PRS), single-cell transcriptomics, and integrative genomics to support precision medicine and clinical translation.\",\"sameAs\":[\"https:\\\/\\\/x.com\\\/HuiQiQu\"],\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/author\\\/hqiqu\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"A component of MICOS (APOO\/MIC26) associated with a new X-linked mitochondrial myopathy, lactic acidosis, cognitive impairment and autistic features (Contributed by Dr. Cristiane Beninc\u00e1) - JMG Contact blog","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/blogs.bmj.com\/jmg\/2020\/05\/22\/a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features\/","og_locale":"en_US","og_type":"article","og_title":"A component of MICOS (APOO\/MIC26) associated with a new X-linked mitochondrial myopathy, lactic acidosis, cognitive impairment and autistic features (Contributed by Dr. Cristiane Beninc\u00e1) - JMG Contact blog","og_description":"Researchers from UK, Brazil and Italy identified the first family with a syndrome due to a mutation in APOO encoding MIC26, a component of the Mitochondrial Contact Site and Cristae Organizing System (MICOS). MICOS is considered the \u201cmitoskeleton\u201d, organizing the organelle cristae. The pathogenic change in MIC26 hits the hydrophobic region of the protein, compromising [...]Read More...","og_url":"https:\/\/blogs.bmj.com\/jmg\/2020\/05\/22\/a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features\/","og_site_name":"JMG Contact blog","article_published_time":"2020-05-22T02:46:34+00:00","article_modified_time":"2026-02-24T00:04:04+00:00","og_image":[{"width":1520,"height":1259,"url":"https:\/\/blogs.bmj.com\/jmg\/files\/2020\/05\/APOO_Scheme.png","type":"image\/png"}],"author":"hqqu","twitter_card":"summary_large_image","twitter_creator":"@HuiQiQu","twitter_misc":{"Written by":"hqqu","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/blogs.bmj.com\/jmg\/2020\/05\/22\/a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features\/#article","isPartOf":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2020\/05\/22\/a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features\/"},"author":{"name":"hqqu","@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/person\/be0250f8d5b52412c3e7c222dabd591b"},"headline":"A component of MICOS (APOO\/MIC26) associated with a new X-linked mitochondrial myopathy, lactic acidosis, cognitive impairment and autistic features (Contributed by Dr. Cristiane Beninc\u00e1)","datePublished":"2020-05-22T02:46:34+00:00","dateModified":"2026-02-24T00:04:04+00:00","mainEntityOfPage":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2020\/05\/22\/a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features\/"},"wordCount":122,"commentCount":0,"publisher":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#organization"},"image":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2020\/05\/22\/a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features\/#primaryimage"},"thumbnailUrl":"https:\/\/blogs.bmj.com\/jmg\/files\/2020\/05\/APOO_Scheme-300x248.png","inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/blogs.bmj.com\/jmg\/2020\/05\/22\/a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/blogs.bmj.com\/jmg\/2020\/05\/22\/a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features\/","url":"https:\/\/blogs.bmj.com\/jmg\/2020\/05\/22\/a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features\/","name":"A component of MICOS (APOO\/MIC26) associated with a new X-linked mitochondrial myopathy, lactic acidosis, cognitive impairment and autistic features (Contributed by Dr. Cristiane Beninc\u00e1) - JMG Contact blog","isPartOf":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#website"},"primaryImageOfPage":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2020\/05\/22\/a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features\/#primaryimage"},"image":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2020\/05\/22\/a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features\/#primaryimage"},"thumbnailUrl":"https:\/\/blogs.bmj.com\/jmg\/files\/2020\/05\/APOO_Scheme-300x248.png","datePublished":"2020-05-22T02:46:34+00:00","dateModified":"2026-02-24T00:04:04+00:00","breadcrumb":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2020\/05\/22\/a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/blogs.bmj.com\/jmg\/2020\/05\/22\/a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/blogs.bmj.com\/jmg\/2020\/05\/22\/a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features\/#primaryimage","url":"https:\/\/blogs.bmj.com\/jmg\/files\/2020\/05\/APOO_Scheme.png","contentUrl":"https:\/\/blogs.bmj.com\/jmg\/files\/2020\/05\/APOO_Scheme.png","width":1520,"height":1259},{"@type":"BreadcrumbList","@id":"https:\/\/blogs.bmj.com\/jmg\/2020\/05\/22\/a-component-of-micos-apoo-mic26-associated-with-a-new-x-linked-mitochondrial-myopathy-lactic-acidosis-cognitive-impairment-and-autistic-features\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/blogs.bmj.com\/jmg\/"},{"@type":"ListItem","position":2,"name":"A component of MICOS (APOO\/MIC26) associated with a new X-linked mitochondrial myopathy, lactic acidosis, cognitive impairment and autistic features (Contributed by Dr. Cristiane Beninc\u00e1)"}]},{"@type":"WebSite","@id":"https:\/\/blogs.bmj.com\/jmg\/#website","url":"https:\/\/blogs.bmj.com\/jmg\/","name":"JMG Contact blog","description":"JMG Contact blog","publisher":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/blogs.bmj.com\/jmg\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/blogs.bmj.com\/jmg\/#organization","name":"JMG Contact blog","url":"https:\/\/blogs.bmj.com\/jmg\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/logo\/image\/","url":"https:\/\/blogs.bmj.com\/jmg\/files\/2017\/10\/blog-logo-jmg.png","contentUrl":"https:\/\/blogs.bmj.com\/jmg\/files\/2017\/10\/blog-logo-jmg.png","width":300,"height":34,"caption":"JMG Contact blog"},"image":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/person\/be0250f8d5b52412c3e7c222dabd591b","name":"hqqu","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g","caption":"hqqu"},"description":"Huiqi Qu has a background as a physician trained in internal medicine and a PhD in Experimental Medicine (Endocrinology). His research applies human genetics and multi-omics to complex and pediatric diseases, including GWAS, polygenic risk scores (PRS), single-cell transcriptomics, and integrative genomics to support precision medicine and clinical translation.","sameAs":["https:\/\/x.com\/HuiQiQu"],"url":"https:\/\/blogs.bmj.com\/jmg\/author\/hqiqu\/"}]}},"_links":{"self":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/1461","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/users\/123"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/comments?post=1461"}],"version-history":[{"count":0,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/1461\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/media?parent=1461"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/categories?post=1461"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/tags?post=1461"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}