{"id":1444,"date":"2020-05-07T15:10:15","date_gmt":"2020-05-07T15:10:15","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=1444"},"modified":"2026-02-24T00:10:15","modified_gmt":"2026-02-24T00:10:15","slug":"understanding-polygenic-models-their-development-and-the-potential-application-of-polygenic-scores-in-healthcare","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2020\/05\/07\/understanding-polygenic-models-their-development-and-the-potential-application-of-polygenic-scores-in-healthcare\/","title":{"rendered":"Understanding polygenic models, their development and the potential application of polygenic scores in healthcare (Contributed by Dr. Chantal Babb de Villiers)"},"content":{"rendered":"

The use of genomic information in the form of polygenic scores as a predictive biomarker for common diseases has been an area of increasing interest. Methods applied in this field have evolved rapidly recently, with several methods proposed in generating these scores. An understanding of these methodological aspects is useful for considerations around implementation in clinical practice. We provide a primer for those outside the field that gives a clear, accessible account on how polygenic scores are constructed, validated and used for disease risk prediction along with an overview of their envisioned uses within health care. (https:\/\/jmg.bmj.com\/content\/early\/2020\/05\/05\/jmedgenet-2019-106763<\/a> )<\/p>\n","protected":false},"excerpt":{"rendered":"

The use of genomic information in the form of polygenic scores as a predictive biomarker for common diseases has been an area of increasing interest. Methods applied in this field have evolved rapidly recently, with several methods proposed in generating these scores. An understanding of these methodological aspects is useful for considerations around implementation in […]<\/p>\n

Read More…<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1444","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"\nUnderstanding polygenic models, their development and the potential application of polygenic scores in healthcare (Contributed by Dr. Chantal Babb de Villiers) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2020\/05\/07\/understanding-polygenic-models-their-development-and-the-potential-application-of-polygenic-scores-in-healthcare\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Understanding polygenic models, their development and the potential application of polygenic scores in healthcare (Contributed by Dr. Chantal Babb de Villiers) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"The use of genomic information in the form of polygenic scores as a predictive biomarker for common diseases has been an area of increasing interest. 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