{"id":1429,"date":"2020-03-14T12:59:05","date_gmt":"2020-03-14T12:59:05","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=1429"},"modified":"2026-02-24T00:13:33","modified_gmt":"2026-02-24T00:13:33","slug":"colorectal-cancer-genetic-variants-are-also-associated-with-serrated-polyposis-syndrome-susceptibility","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2020\/03\/14\/colorectal-cancer-genetic-variants-are-also-associated-with-serrated-polyposis-syndrome-susceptibility\/","title":{"rendered":"Colorectal cancer genetic variants are also associated with serrated polyposis syndrome susceptibility (Contributed by Dr. Sergi Castellv\u00ed-Bel)"},"content":{"rendered":"<p>Serrated polyposis syndrome (SPS) is a clinical entity characterized by large and multiple serrated polyps throughout the colon and increased risk for colorectal cancer (CRC). Serrated polyps are considered CRC precursor lesions. Despite recent results in CRC genome-wide studies, the germline predisposition of SPS remains largely unknown. This study is the first to evaluate the association between CRC risk genetic variants and SPS susceptibility. Our results showed significant associations for seven genetic variants including one located in the <em>GREM1<\/em> gene, previously involved in hereditary mixed polyposis. These results could be used to identify a subgroup of individuals with increased SPS\/CRC risk and modulate population-based prevention measures. (<a href=\"https:\/\/jmg.bmj.com\/content\/early\/2020\/03\/13\/jmedgenet-2019-106374\">https:\/\/jmg.bmj.com\/content\/early\/2020\/03\/13\/jmedgenet-2019-106374<\/a> )<\/p>\n<p><a href=\"https:\/\/blogs.bmj.com\/jmg\/2020\/03\/14\/colorectal-cancer-genetic-variants-are-also-associated-with-serrated-polyposis-syndrome-susceptibility\/untitled-27\/\" rel=\"attachment wp-att-1430\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-1430\" src=\"https:\/\/blogs.bmj.com\/jmg\/files\/2020\/03\/Untitled-3-300x225.jpg\" alt=\"\" width=\"300\" height=\"225\" srcset=\"https:\/\/blogs.bmj.com\/jmg\/files\/2020\/03\/Untitled-3-300x225.jpg 300w, https:\/\/blogs.bmj.com\/jmg\/files\/2020\/03\/Untitled-3.jpg 567w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Serrated polyposis syndrome (SPS) is a clinical entity characterized by large and multiple serrated polyps throughout the colon and increased risk for colorectal cancer (CRC). Serrated polyps are considered CRC precursor lesions. Despite recent results in CRC genome-wide studies, the germline predisposition of SPS remains largely unknown. This study is the first to evaluate the [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2020\/03\/14\/colorectal-cancer-genetic-variants-are-also-associated-with-serrated-polyposis-syndrome-susceptibility\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1429","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Colorectal cancer genetic variants are also associated with serrated polyposis syndrome susceptibility (Contributed by Dr. Sergi Castellv\u00ed-Bel) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2020\/03\/14\/colorectal-cancer-genetic-variants-are-also-associated-with-serrated-polyposis-syndrome-susceptibility\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Colorectal cancer genetic variants are also associated with serrated polyposis syndrome susceptibility (Contributed by Dr. Sergi Castellv\u00ed-Bel) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Serrated polyposis syndrome (SPS) is a clinical entity characterized by large and multiple serrated polyps throughout the colon and increased risk for colorectal cancer (CRC). Serrated polyps are considered CRC precursor lesions. Despite recent results in CRC genome-wide studies, the germline predisposition of SPS remains largely unknown. This study is the first to evaluate the [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2020\/03\/14\/colorectal-cancer-genetic-variants-are-also-associated-with-serrated-polyposis-syndrome-susceptibility\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2020-03-14T12:59:05+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-24T00:13:33+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/blogs.bmj.com\/jmg\/files\/2020\/03\/Untitled-3.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"567\" \/>\n\t<meta property=\"og:image:height\" content=\"425\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/03\\\/14\\\/colorectal-cancer-genetic-variants-are-also-associated-with-serrated-polyposis-syndrome-susceptibility\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/03\\\/14\\\/colorectal-cancer-genetic-variants-are-also-associated-with-serrated-polyposis-syndrome-susceptibility\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Colorectal cancer genetic variants are also associated with serrated polyposis syndrome susceptibility (Contributed by Dr. Sergi Castellv\u00ed-Bel)\",\"datePublished\":\"2020-03-14T12:59:05+00:00\",\"dateModified\":\"2026-02-24T00:13:33+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/03\\\/14\\\/colorectal-cancer-genetic-variants-are-also-associated-with-serrated-polyposis-syndrome-susceptibility\\\/\"},\"wordCount\":133,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/03\\\/14\\\/colorectal-cancer-genetic-variants-are-also-associated-with-serrated-polyposis-syndrome-susceptibility\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2020\\\/03\\\/Untitled-3-300x225.jpg\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/03\\\/14\\\/colorectal-cancer-genetic-variants-are-also-associated-with-serrated-polyposis-syndrome-susceptibility\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/03\\\/14\\\/colorectal-cancer-genetic-variants-are-also-associated-with-serrated-polyposis-syndrome-susceptibility\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/03\\\/14\\\/colorectal-cancer-genetic-variants-are-also-associated-with-serrated-polyposis-syndrome-susceptibility\\\/\",\"name\":\"Colorectal cancer genetic variants are also associated with serrated polyposis syndrome susceptibility (Contributed by Dr. Sergi Castellv\u00ed-Bel) - 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