{"id":1417,"date":"2020-02-18T14:35:07","date_gmt":"2020-02-18T14:35:07","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=1417"},"modified":"2026-02-24T00:16:18","modified_gmt":"2026-02-24T00:16:18","slug":"re-definition-of-familial-intestinal-gastric-cancer-clinical-and-genetic-perspectives","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2020\/02\/18\/re-definition-of-familial-intestinal-gastric-cancer-clinical-and-genetic-perspectives\/","title":{"rendered":"RE-DEFINITION OF FAMILIAL INTESTINAL GASTRIC CANCER: CLINICAL AND GENETIC PERSPECTIVES (Contributed by Dr. Carla Oliveira)"},"content":{"rendered":"

Familial Intestinal Gastric Cancer (FIGC) remains genetically unexplained and poorly characterized, preventing the design of testing criteria for genetic diagnosis. We analyzed family trees from FIGC families and compared their tumour and normal genetic profiles with those of sporadic stomach cancer patients. We found that FIGC families present 2 or more stomach cancers, but may also show colorectal and breast cancers; that stomach cancer arises, on average, 10 years earlier than in patients with sporadic stomach cancer, and; that tumours and normal cells from familial cases are genetically different sporadic cases. Our study proposes the first testing criteria for FIGC families and provides compelling evidence that this familial disease is genetically determined. (https:\/\/jmg.bmj.com\/content\/early\/2020\/02\/17\/jmedgenet-2019-106346<\/a> )<\/p>\n","protected":false},"excerpt":{"rendered":"

Familial Intestinal Gastric Cancer (FIGC) remains genetically unexplained and poorly characterized, preventing the design of testing criteria for genetic diagnosis. We analyzed family trees from FIGC families and compared their tumour and normal genetic profiles with those of sporadic stomach cancer patients. We found that FIGC families present 2 or more stomach cancers, but may […]<\/p>\n

Read More…<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1417","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"\nRE-DEFINITION OF FAMILIAL INTESTINAL GASTRIC CANCER: CLINICAL AND GENETIC PERSPECTIVES (Contributed by Dr. Carla Oliveira) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2020\/02\/18\/re-definition-of-familial-intestinal-gastric-cancer-clinical-and-genetic-perspectives\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"RE-DEFINITION OF FAMILIAL INTESTINAL GASTRIC CANCER: CLINICAL AND GENETIC PERSPECTIVES (Contributed by Dr. Carla Oliveira) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Familial Intestinal Gastric Cancer (FIGC) remains genetically unexplained and poorly characterized, preventing the design of testing criteria for genetic diagnosis. We analyzed family trees from FIGC families and compared their tumour and normal genetic profiles with those of sporadic stomach cancer patients. We found that FIGC families present 2 or more stomach cancers, but may [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2020\/02\/18\/re-definition-of-familial-intestinal-gastric-cancer-clinical-and-genetic-perspectives\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2020-02-18T14:35:07+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-24T00:16:18+00:00\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/02\\\/18\\\/re-definition-of-familial-intestinal-gastric-cancer-clinical-and-genetic-perspectives\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/02\\\/18\\\/re-definition-of-familial-intestinal-gastric-cancer-clinical-and-genetic-perspectives\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"RE-DEFINITION OF FAMILIAL INTESTINAL GASTRIC CANCER: CLINICAL AND GENETIC PERSPECTIVES (Contributed by Dr. Carla Oliveira)\",\"datePublished\":\"2020-02-18T14:35:07+00:00\",\"dateModified\":\"2026-02-24T00:16:18+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/02\\\/18\\\/re-definition-of-familial-intestinal-gastric-cancer-clinical-and-genetic-perspectives\\\/\"},\"wordCount\":133,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/02\\\/18\\\/re-definition-of-familial-intestinal-gastric-cancer-clinical-and-genetic-perspectives\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/02\\\/18\\\/re-definition-of-familial-intestinal-gastric-cancer-clinical-and-genetic-perspectives\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/02\\\/18\\\/re-definition-of-familial-intestinal-gastric-cancer-clinical-and-genetic-perspectives\\\/\",\"name\":\"RE-DEFINITION OF FAMILIAL INTESTINAL GASTRIC CANCER: CLINICAL AND GENETIC PERSPECTIVES (Contributed by Dr. Carla Oliveira) - JMG Contact blog\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#website\"},\"datePublished\":\"2020-02-18T14:35:07+00:00\",\"dateModified\":\"2026-02-24T00:16:18+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/02\\\/18\\\/re-definition-of-familial-intestinal-gastric-cancer-clinical-and-genetic-perspectives\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/02\\\/18\\\/re-definition-of-familial-intestinal-gastric-cancer-clinical-and-genetic-perspectives\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/02\\\/18\\\/re-definition-of-familial-intestinal-gastric-cancer-clinical-and-genetic-perspectives\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"RE-DEFINITION OF FAMILIAL INTESTINAL GASTRIC CANCER: CLINICAL AND GENETIC PERSPECTIVES (Contributed by Dr. Carla Oliveira)\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#website\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/\",\"name\":\"JMG Contact blog\",\"description\":\"JMG Contact blog\",\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\",\"name\":\"JMG Contact blog\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2017\\\/10\\\/blog-logo-jmg.png\",\"contentUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2017\\\/10\\\/blog-logo-jmg.png\",\"width\":300,\"height\":34,\"caption\":\"JMG Contact blog\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\",\"name\":\"hqqu\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g\",\"caption\":\"hqqu\"},\"description\":\"Huiqi Qu has a background as a physician trained in internal medicine and a PhD in Experimental Medicine (Endocrinology). His research applies human genetics and multi-omics to complex and pediatric diseases, including GWAS, polygenic risk scores (PRS), single-cell transcriptomics, and integrative genomics to support precision medicine and clinical translation.\",\"sameAs\":[\"https:\\\/\\\/x.com\\\/HuiQiQu\"],\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/author\\\/hqiqu\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"RE-DEFINITION OF FAMILIAL INTESTINAL GASTRIC CANCER: CLINICAL AND GENETIC PERSPECTIVES (Contributed by Dr. Carla Oliveira) - JMG Contact blog","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/blogs.bmj.com\/jmg\/2020\/02\/18\/re-definition-of-familial-intestinal-gastric-cancer-clinical-and-genetic-perspectives\/","og_locale":"en_US","og_type":"article","og_title":"RE-DEFINITION OF FAMILIAL INTESTINAL GASTRIC CANCER: CLINICAL AND GENETIC PERSPECTIVES (Contributed by Dr. Carla Oliveira) - JMG Contact blog","og_description":"Familial Intestinal Gastric Cancer (FIGC) remains genetically unexplained and poorly characterized, preventing the design of testing criteria for genetic diagnosis. We analyzed family trees from FIGC families and compared their tumour and normal genetic profiles with those of sporadic stomach cancer patients. We found that FIGC families present 2 or more stomach cancers, but may [...]Read More...","og_url":"https:\/\/blogs.bmj.com\/jmg\/2020\/02\/18\/re-definition-of-familial-intestinal-gastric-cancer-clinical-and-genetic-perspectives\/","og_site_name":"JMG Contact blog","article_published_time":"2020-02-18T14:35:07+00:00","article_modified_time":"2026-02-24T00:16:18+00:00","author":"hqqu","twitter_card":"summary_large_image","twitter_creator":"@HuiQiQu","twitter_misc":{"Written by":"hqqu","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/blogs.bmj.com\/jmg\/2020\/02\/18\/re-definition-of-familial-intestinal-gastric-cancer-clinical-and-genetic-perspectives\/#article","isPartOf":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2020\/02\/18\/re-definition-of-familial-intestinal-gastric-cancer-clinical-and-genetic-perspectives\/"},"author":{"name":"hqqu","@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/person\/be0250f8d5b52412c3e7c222dabd591b"},"headline":"RE-DEFINITION OF FAMILIAL INTESTINAL GASTRIC CANCER: CLINICAL AND GENETIC PERSPECTIVES (Contributed by Dr. Carla Oliveira)","datePublished":"2020-02-18T14:35:07+00:00","dateModified":"2026-02-24T00:16:18+00:00","mainEntityOfPage":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2020\/02\/18\/re-definition-of-familial-intestinal-gastric-cancer-clinical-and-genetic-perspectives\/"},"wordCount":133,"commentCount":0,"publisher":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#organization"},"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/blogs.bmj.com\/jmg\/2020\/02\/18\/re-definition-of-familial-intestinal-gastric-cancer-clinical-and-genetic-perspectives\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/blogs.bmj.com\/jmg\/2020\/02\/18\/re-definition-of-familial-intestinal-gastric-cancer-clinical-and-genetic-perspectives\/","url":"https:\/\/blogs.bmj.com\/jmg\/2020\/02\/18\/re-definition-of-familial-intestinal-gastric-cancer-clinical-and-genetic-perspectives\/","name":"RE-DEFINITION OF FAMILIAL INTESTINAL GASTRIC CANCER: CLINICAL AND GENETIC PERSPECTIVES (Contributed by Dr. Carla Oliveira) - JMG Contact blog","isPartOf":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#website"},"datePublished":"2020-02-18T14:35:07+00:00","dateModified":"2026-02-24T00:16:18+00:00","breadcrumb":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2020\/02\/18\/re-definition-of-familial-intestinal-gastric-cancer-clinical-and-genetic-perspectives\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/blogs.bmj.com\/jmg\/2020\/02\/18\/re-definition-of-familial-intestinal-gastric-cancer-clinical-and-genetic-perspectives\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/blogs.bmj.com\/jmg\/2020\/02\/18\/re-definition-of-familial-intestinal-gastric-cancer-clinical-and-genetic-perspectives\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/blogs.bmj.com\/jmg\/"},{"@type":"ListItem","position":2,"name":"RE-DEFINITION OF FAMILIAL INTESTINAL GASTRIC CANCER: CLINICAL AND GENETIC PERSPECTIVES (Contributed by Dr. Carla Oliveira)"}]},{"@type":"WebSite","@id":"https:\/\/blogs.bmj.com\/jmg\/#website","url":"https:\/\/blogs.bmj.com\/jmg\/","name":"JMG Contact blog","description":"JMG Contact blog","publisher":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/blogs.bmj.com\/jmg\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/blogs.bmj.com\/jmg\/#organization","name":"JMG Contact blog","url":"https:\/\/blogs.bmj.com\/jmg\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/logo\/image\/","url":"https:\/\/blogs.bmj.com\/jmg\/files\/2017\/10\/blog-logo-jmg.png","contentUrl":"https:\/\/blogs.bmj.com\/jmg\/files\/2017\/10\/blog-logo-jmg.png","width":300,"height":34,"caption":"JMG Contact blog"},"image":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/person\/be0250f8d5b52412c3e7c222dabd591b","name":"hqqu","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g","caption":"hqqu"},"description":"Huiqi Qu has a background as a physician trained in internal medicine and a PhD in Experimental Medicine (Endocrinology). His research applies human genetics and multi-omics to complex and pediatric diseases, including GWAS, polygenic risk scores (PRS), single-cell transcriptomics, and integrative genomics to support precision medicine and clinical translation.","sameAs":["https:\/\/x.com\/HuiQiQu"],"url":"https:\/\/blogs.bmj.com\/jmg\/author\/hqiqu\/"}]}},"_links":{"self":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/1417","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/users\/123"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/comments?post=1417"}],"version-history":[{"count":0,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/1417\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/media?parent=1417"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/categories?post=1417"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/tags?post=1417"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}