{"id":1414,"date":"2020-02-14T15:22:37","date_gmt":"2020-02-14T15:22:37","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=1414"},"modified":"2026-02-24T00:17:22","modified_gmt":"2026-02-24T00:17:22","slug":"phenotype-of-genetically-confirmed-silver-russell-syndrome-beyond-childhood","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2020\/02\/14\/phenotype-of-genetically-confirmed-silver-russell-syndrome-beyond-childhood\/","title":{"rendered":"Phenotype of genetically confirmed Silver-Russell syndrome beyond childhood (Contributed by Dr. Karen Temple)"},"content":{"rendered":"<p>Silver Russell syndrome (SRS) is a rare disorder affecting growth and behaviour, caused by faults in the biological control of growth factors vital to early development. We studied the medical history of 33 older people with SRS.<br \/>\n60% had significantly reduced height, though 70% had received treatment; this suggests a need for improved intervention. In those 18 years and older, one quarter either had an increased risk of diabetes or had developed it, one third had high blood pressure and half had raised cholesterol.\u00a0 This shows that further investigation of metabolic health is warranted.\u00a0 Even so, the group had normal educational achievement and quality of life, in many cases including fertility. (<a href=\"https:\/\/jmg.bmj.com\/content\/early\/2020\/02\/13\/jmedgenet-2019-106561\">https:\/\/jmg.bmj.com\/content\/early\/2020\/02\/13\/jmedgenet-2019-106561<\/a> )<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Silver Russell syndrome (SRS) is a rare disorder affecting growth and behaviour, caused by faults in the biological control of growth factors vital to early development. We studied the medical history of 33 older people with SRS. 60% had significantly reduced height, though 70% had received treatment; this suggests a need for improved intervention. In [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2020\/02\/14\/phenotype-of-genetically-confirmed-silver-russell-syndrome-beyond-childhood\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1414","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Phenotype of genetically confirmed Silver-Russell syndrome beyond childhood (Contributed by Dr. Karen Temple) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2020\/02\/14\/phenotype-of-genetically-confirmed-silver-russell-syndrome-beyond-childhood\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Phenotype of genetically confirmed Silver-Russell syndrome beyond childhood (Contributed by Dr. Karen Temple) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Silver Russell syndrome (SRS) is a rare disorder affecting growth and behaviour, caused by faults in the biological control of growth factors vital to early development. We studied the medical history of 33 older people with SRS. 60% had significantly reduced height, though 70% had received treatment; this suggests a need for improved intervention. In [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2020\/02\/14\/phenotype-of-genetically-confirmed-silver-russell-syndrome-beyond-childhood\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2020-02-14T15:22:37+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-24T00:17:22+00:00\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/02\\\/14\\\/phenotype-of-genetically-confirmed-silver-russell-syndrome-beyond-childhood\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/02\\\/14\\\/phenotype-of-genetically-confirmed-silver-russell-syndrome-beyond-childhood\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Phenotype of genetically confirmed Silver-Russell syndrome beyond childhood (Contributed by Dr. Karen Temple)\",\"datePublished\":\"2020-02-14T15:22:37+00:00\",\"dateModified\":\"2026-02-24T00:17:22+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/02\\\/14\\\/phenotype-of-genetically-confirmed-silver-russell-syndrome-beyond-childhood\\\/\"},\"wordCount\":128,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/02\\\/14\\\/phenotype-of-genetically-confirmed-silver-russell-syndrome-beyond-childhood\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/02\\\/14\\\/phenotype-of-genetically-confirmed-silver-russell-syndrome-beyond-childhood\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2020\\\/02\\\/14\\\/phenotype-of-genetically-confirmed-silver-russell-syndrome-beyond-childhood\\\/\",\"name\":\"Phenotype of genetically confirmed Silver-Russell syndrome beyond childhood (Contributed by Dr. Karen Temple) - 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