{"id":1338,"date":"2019-09-14T13:19:38","date_gmt":"2019-09-14T13:19:38","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=1338"},"modified":"2026-02-24T00:27:45","modified_gmt":"2026-02-24T00:27:45","slug":"impact-of-dna-source-on-genetic-variant-detection-from-human-whole-genome-sequencing-data","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2019\/09\/14\/impact-of-dna-source-on-genetic-variant-detection-from-human-whole-genome-sequencing-data\/","title":{"rendered":"Impact of DNA source on genetic variant detection from human whole-genome sequencing data (Contributed by Dr. Brett Trost)"},"content":{"rendered":"

Whole-genome sequencing (WGS) is the most comprehensive genetic test possible, theoretically allowing the detection of all types of genetic variants. With decreasing DNA sequencing costs, we can now consider applying WGS to worldwide populations, but this requires the collection of DNA samples. While blood is the traditional source of DNA, saliva and buccal (cheek) samples are less invasive to collect and easier to ship. We compared the accuracy of WGS from blood, saliva, and buccal sources, and showed that while blood samples are best, saliva and buccal samples are nearly as good, and thus can be used for population-scale WGS. (https:\/\/jmg.bmj.com\/content\/early\/2019\/09\/11\/jmedgenet-2019-106281<\/a> )<\/p>\n","protected":false},"excerpt":{"rendered":"

Whole-genome sequencing (WGS) is the most comprehensive genetic test possible, theoretically allowing the detection of all types of genetic variants. With decreasing DNA sequencing costs, we can now consider applying WGS to worldwide populations, but this requires the collection of DNA samples. While blood is the traditional source of DNA, saliva and buccal (cheek) samples […]<\/p>\n

Read More…<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1338","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"\nImpact of DNA source on genetic variant detection from human whole-genome sequencing data (Contributed by Dr. Brett Trost) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2019\/09\/14\/impact-of-dna-source-on-genetic-variant-detection-from-human-whole-genome-sequencing-data\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Impact of DNA source on genetic variant detection from human whole-genome sequencing data (Contributed by Dr. Brett Trost) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Whole-genome sequencing (WGS) is the most comprehensive genetic test possible, theoretically allowing the detection of all types of genetic variants. 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