{"id":1327,"date":"2019-09-02T15:51:26","date_gmt":"2019-09-02T15:51:26","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=1327"},"modified":"2026-02-24T00:30:57","modified_gmt":"2026-02-24T00:30:57","slug":"differential-disruption-of-autoinhibition-and-defect-in-assembly-of-cytoskeleton-during-cell-division-decide-the-fate-of-human-diaph1-related-cytoskeletopathy","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2019\/09\/02\/differential-disruption-of-autoinhibition-and-defect-in-assembly-of-cytoskeleton-during-cell-division-decide-the-fate-of-human-diaph1-related-cytoskeletopathy\/","title":{"rendered":"Differential disruption of autoinhibition and defect in assembly of cytoskeleton during cell division decide the fate of human DIAPH1-related cytoskeletopathy (Contributed by Dr. Bong Jik Kim)"},"content":{"rendered":"<p>Diaphanous-related formins1 (DIA1) is a protein, encoded by <em>DIAPH1<\/em> and it assembles the unbranched actin microfilament and microtubule cytoskeleton. As it functions in blood cell as well as hair cell in the cochlea, constitutive activation by the disruption of autoinhibitory interactions between the diaphanous inhibitory domain (DID) and diaphanous auto regulatory domain (DAD) caused by the mutants in the DAD, was reported to result in both hearing loss and blood cell abnormalities. Here, we report the first mutant in the DID of humans with only hearing loss and reveal that the differential cell biological phenotypes of DIA1 during cell division appear to be potential determinants of the clinical severity of <em>DIAPH1-<\/em>related cytoskeletopathy in humans. (<a href=\"https:\/\/jmg.bmj.com\/content\/early\/2019\/08\/31\/jmedgenet-2019-106282\">https:\/\/jmg.bmj.com\/content\/early\/2019\/08\/31\/jmedgenet-2019-106282<\/a> )<!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Diaphanous-related formins1 (DIA1) is a protein, encoded by DIAPH1 and it assembles the unbranched actin microfilament and microtubule cytoskeleton. As it functions in blood cell as well as hair cell in the cochlea, constitutive activation by the disruption of autoinhibitory interactions between the diaphanous inhibitory domain (DID) and diaphanous auto regulatory domain (DAD) caused by [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2019\/09\/02\/differential-disruption-of-autoinhibition-and-defect-in-assembly-of-cytoskeleton-during-cell-division-decide-the-fate-of-human-diaph1-related-cytoskeletopathy\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1327","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Differential disruption of autoinhibition and defect in assembly of cytoskeleton during cell division decide the fate of human DIAPH1-related cytoskeletopathy (Contributed by Dr. Bong Jik Kim) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2019\/09\/02\/differential-disruption-of-autoinhibition-and-defect-in-assembly-of-cytoskeleton-during-cell-division-decide-the-fate-of-human-diaph1-related-cytoskeletopathy\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Differential disruption of autoinhibition and defect in assembly of cytoskeleton during cell division decide the fate of human DIAPH1-related cytoskeletopathy (Contributed by Dr. Bong Jik Kim) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Diaphanous-related formins1 (DIA1) is a protein, encoded by DIAPH1 and it assembles the unbranched actin microfilament and microtubule cytoskeleton. As it functions in blood cell as well as hair cell in the cochlea, constitutive activation by the disruption of autoinhibitory interactions between the diaphanous inhibitory domain (DID) and diaphanous auto regulatory domain (DAD) caused by [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2019\/09\/02\/differential-disruption-of-autoinhibition-and-defect-in-assembly-of-cytoskeleton-during-cell-division-decide-the-fate-of-human-diaph1-related-cytoskeletopathy\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2019-09-02T15:51:26+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-24T00:30:57+00:00\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2019\\\/09\\\/02\\\/differential-disruption-of-autoinhibition-and-defect-in-assembly-of-cytoskeleton-during-cell-division-decide-the-fate-of-human-diaph1-related-cytoskeletopathy\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2019\\\/09\\\/02\\\/differential-disruption-of-autoinhibition-and-defect-in-assembly-of-cytoskeleton-during-cell-division-decide-the-fate-of-human-diaph1-related-cytoskeletopathy\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Differential disruption of autoinhibition and defect in assembly of cytoskeleton during cell division decide the fate of human DIAPH1-related cytoskeletopathy (Contributed by Dr. Bong Jik Kim)\",\"datePublished\":\"2019-09-02T15:51:26+00:00\",\"dateModified\":\"2026-02-24T00:30:57+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2019\\\/09\\\/02\\\/differential-disruption-of-autoinhibition-and-defect-in-assembly-of-cytoskeleton-during-cell-division-decide-the-fate-of-human-diaph1-related-cytoskeletopathy\\\/\"},\"wordCount\":150,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2019\\\/09\\\/02\\\/differential-disruption-of-autoinhibition-and-defect-in-assembly-of-cytoskeleton-during-cell-division-decide-the-fate-of-human-diaph1-related-cytoskeletopathy\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2019\\\/09\\\/02\\\/differential-disruption-of-autoinhibition-and-defect-in-assembly-of-cytoskeleton-during-cell-division-decide-the-fate-of-human-diaph1-related-cytoskeletopathy\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2019\\\/09\\\/02\\\/differential-disruption-of-autoinhibition-and-defect-in-assembly-of-cytoskeleton-during-cell-division-decide-the-fate-of-human-diaph1-related-cytoskeletopathy\\\/\",\"name\":\"Differential disruption of autoinhibition and defect in assembly of cytoskeleton during cell division decide the fate of human DIAPH1-related cytoskeletopathy (Contributed by Dr. Bong Jik Kim) - JMG Contact blog\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#website\"},\"datePublished\":\"2019-09-02T15:51:26+00:00\",\"dateModified\":\"2026-02-24T00:30:57+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2019\\\/09\\\/02\\\/differential-disruption-of-autoinhibition-and-defect-in-assembly-of-cytoskeleton-during-cell-division-decide-the-fate-of-human-diaph1-related-cytoskeletopathy\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2019\\\/09\\\/02\\\/differential-disruption-of-autoinhibition-and-defect-in-assembly-of-cytoskeleton-during-cell-division-decide-the-fate-of-human-diaph1-related-cytoskeletopathy\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2019\\\/09\\\/02\\\/differential-disruption-of-autoinhibition-and-defect-in-assembly-of-cytoskeleton-during-cell-division-decide-the-fate-of-human-diaph1-related-cytoskeletopathy\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Differential disruption of autoinhibition and defect in assembly of cytoskeleton during cell division decide the fate of human DIAPH1-related cytoskeletopathy (Contributed by Dr. Bong Jik Kim)\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#website\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/\",\"name\":\"JMG Contact blog\",\"description\":\"JMG Contact blog\",\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\",\"name\":\"JMG Contact blog\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2017\\\/10\\\/blog-logo-jmg.png\",\"contentUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2017\\\/10\\\/blog-logo-jmg.png\",\"width\":300,\"height\":34,\"caption\":\"JMG Contact blog\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\",\"name\":\"hqqu\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g\",\"caption\":\"hqqu\"},\"description\":\"Huiqi Qu has a background as a physician trained in internal medicine and a PhD in Experimental Medicine (Endocrinology). His research applies human genetics and multi-omics to complex and pediatric diseases, including GWAS, polygenic risk scores (PRS), single-cell transcriptomics, and integrative genomics to support precision medicine and clinical translation.\",\"sameAs\":[\"https:\\\/\\\/x.com\\\/HuiQiQu\"],\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/author\\\/hqiqu\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Differential disruption of autoinhibition and defect in assembly of cytoskeleton during cell division decide the fate of human DIAPH1-related cytoskeletopathy (Contributed by Dr. Bong Jik Kim) - JMG Contact blog","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/blogs.bmj.com\/jmg\/2019\/09\/02\/differential-disruption-of-autoinhibition-and-defect-in-assembly-of-cytoskeleton-during-cell-division-decide-the-fate-of-human-diaph1-related-cytoskeletopathy\/","og_locale":"en_US","og_type":"article","og_title":"Differential disruption of autoinhibition and defect in assembly of cytoskeleton during cell division decide the fate of human DIAPH1-related cytoskeletopathy (Contributed by Dr. Bong Jik Kim) - JMG Contact blog","og_description":"Diaphanous-related formins1 (DIA1) is a protein, encoded by DIAPH1 and it assembles the unbranched actin microfilament and microtubule cytoskeleton. As it functions in blood cell as well as hair cell in the cochlea, constitutive activation by the disruption of autoinhibitory interactions between the diaphanous inhibitory domain (DID) and diaphanous auto regulatory domain (DAD) caused by [...]Read More...","og_url":"https:\/\/blogs.bmj.com\/jmg\/2019\/09\/02\/differential-disruption-of-autoinhibition-and-defect-in-assembly-of-cytoskeleton-during-cell-division-decide-the-fate-of-human-diaph1-related-cytoskeletopathy\/","og_site_name":"JMG Contact blog","article_published_time":"2019-09-02T15:51:26+00:00","article_modified_time":"2026-02-24T00:30:57+00:00","author":"hqqu","twitter_card":"summary_large_image","twitter_creator":"@HuiQiQu","twitter_misc":{"Written by":"hqqu","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/blogs.bmj.com\/jmg\/2019\/09\/02\/differential-disruption-of-autoinhibition-and-defect-in-assembly-of-cytoskeleton-during-cell-division-decide-the-fate-of-human-diaph1-related-cytoskeletopathy\/#article","isPartOf":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2019\/09\/02\/differential-disruption-of-autoinhibition-and-defect-in-assembly-of-cytoskeleton-during-cell-division-decide-the-fate-of-human-diaph1-related-cytoskeletopathy\/"},"author":{"name":"hqqu","@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/person\/be0250f8d5b52412c3e7c222dabd591b"},"headline":"Differential disruption of autoinhibition and defect in assembly of cytoskeleton during cell division decide the fate of human DIAPH1-related cytoskeletopathy (Contributed by Dr. Bong Jik Kim)","datePublished":"2019-09-02T15:51:26+00:00","dateModified":"2026-02-24T00:30:57+00:00","mainEntityOfPage":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2019\/09\/02\/differential-disruption-of-autoinhibition-and-defect-in-assembly-of-cytoskeleton-during-cell-division-decide-the-fate-of-human-diaph1-related-cytoskeletopathy\/"},"wordCount":150,"commentCount":0,"publisher":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#organization"},"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/blogs.bmj.com\/jmg\/2019\/09\/02\/differential-disruption-of-autoinhibition-and-defect-in-assembly-of-cytoskeleton-during-cell-division-decide-the-fate-of-human-diaph1-related-cytoskeletopathy\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/blogs.bmj.com\/jmg\/2019\/09\/02\/differential-disruption-of-autoinhibition-and-defect-in-assembly-of-cytoskeleton-during-cell-division-decide-the-fate-of-human-diaph1-related-cytoskeletopathy\/","url":"https:\/\/blogs.bmj.com\/jmg\/2019\/09\/02\/differential-disruption-of-autoinhibition-and-defect-in-assembly-of-cytoskeleton-during-cell-division-decide-the-fate-of-human-diaph1-related-cytoskeletopathy\/","name":"Differential disruption of autoinhibition and defect in assembly of cytoskeleton during cell division decide the fate of human DIAPH1-related cytoskeletopathy (Contributed by Dr. Bong Jik Kim) - JMG Contact blog","isPartOf":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#website"},"datePublished":"2019-09-02T15:51:26+00:00","dateModified":"2026-02-24T00:30:57+00:00","breadcrumb":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2019\/09\/02\/differential-disruption-of-autoinhibition-and-defect-in-assembly-of-cytoskeleton-during-cell-division-decide-the-fate-of-human-diaph1-related-cytoskeletopathy\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/blogs.bmj.com\/jmg\/2019\/09\/02\/differential-disruption-of-autoinhibition-and-defect-in-assembly-of-cytoskeleton-during-cell-division-decide-the-fate-of-human-diaph1-related-cytoskeletopathy\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/blogs.bmj.com\/jmg\/2019\/09\/02\/differential-disruption-of-autoinhibition-and-defect-in-assembly-of-cytoskeleton-during-cell-division-decide-the-fate-of-human-diaph1-related-cytoskeletopathy\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/blogs.bmj.com\/jmg\/"},{"@type":"ListItem","position":2,"name":"Differential disruption of autoinhibition and defect in assembly of cytoskeleton during cell division decide the fate of human DIAPH1-related cytoskeletopathy (Contributed by Dr. Bong Jik Kim)"}]},{"@type":"WebSite","@id":"https:\/\/blogs.bmj.com\/jmg\/#website","url":"https:\/\/blogs.bmj.com\/jmg\/","name":"JMG Contact blog","description":"JMG Contact blog","publisher":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/blogs.bmj.com\/jmg\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/blogs.bmj.com\/jmg\/#organization","name":"JMG Contact blog","url":"https:\/\/blogs.bmj.com\/jmg\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/logo\/image\/","url":"https:\/\/blogs.bmj.com\/jmg\/files\/2017\/10\/blog-logo-jmg.png","contentUrl":"https:\/\/blogs.bmj.com\/jmg\/files\/2017\/10\/blog-logo-jmg.png","width":300,"height":34,"caption":"JMG Contact blog"},"image":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/person\/be0250f8d5b52412c3e7c222dabd591b","name":"hqqu","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g","caption":"hqqu"},"description":"Huiqi Qu has a background as a physician trained in internal medicine and a PhD in Experimental Medicine (Endocrinology). His research applies human genetics and multi-omics to complex and pediatric diseases, including GWAS, polygenic risk scores (PRS), single-cell transcriptomics, and integrative genomics to support precision medicine and clinical translation.","sameAs":["https:\/\/x.com\/HuiQiQu"],"url":"https:\/\/blogs.bmj.com\/jmg\/author\/hqiqu\/"}]}},"_links":{"self":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/1327","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/users\/123"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/comments?post=1327"}],"version-history":[{"count":0,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/1327\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/media?parent=1327"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/categories?post=1327"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/tags?post=1327"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}