{"id":128,"date":"2011-03-23T18:40:16","date_gmt":"2011-03-23T18:40:16","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/2011\/03\/23\/unexpected-findings-in-cancer-predisposition-genes-detected-by-array-comparative-genomic-hybridisation-what-are-the-issues\/"},"modified":"2026-02-25T21:12:06","modified_gmt":"2026-02-25T21:12:06","slug":"unexpected-findings-in-cancer-predisposition-genes-detected-by-array-comparative-genomic-hybridisation-what-are-the-issues","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2011\/03\/23\/unexpected-findings-in-cancer-predisposition-genes-detected-by-array-comparative-genomic-hybridisation-what-are-the-issues\/","title":{"rendered":"Unexpected findings in cancer predisposition genes detected by array comparative genomic hybridisation: what are the issues? (Contributed by Dr Gabriella Pichert)"},"content":{"rendered":"

Developmental delay, learning difficulties, behavioural abnormalities and birth defects are often caused by gains or losses of genetic material. \u00a0Array comparative genomic hybridisation (aCGH) is a new technology which is more sensitive than previous technologies, and therefore detects these causative changes and provides a diagnosis in more patients than was previously possible.\u00a0 However, a(CGH) may also identify unexpected changes in genes associated with cancer predisposition. We describe our experience of these unexpected findings following testing of 4805 non-cancer referrals to our Genetics Centre and discuss the need for pre- and post-test genetic counselling and for long term follow-up to establish the cancer-causing relevance of these changes and \u00a0to help shape future policy. (http:\/\/jmg.bmj.com\/content\/early\/2011\/03\/22\/jmg.2010.087593.abstract?papetoc<\/a>)<\/p>\n","protected":false},"excerpt":{"rendered":"

Developmental delay, learning difficulties, behavioural abnormalities and birth defects are often caused by gains or losses of genetic material. \u00a0Array comparative genomic hybridisation (aCGH) is a new technology which is more sensitive than previous technologies, and therefore detects these causative changes and provides a diagnosis in more patients than was previously possible.\u00a0 However, a(CGH) may […]<\/p>\n

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