{"id":1255,"date":"2019-03-26T14:18:36","date_gmt":"2019-03-26T14:18:36","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=1255"},"modified":"2026-02-24T00:45:22","modified_gmt":"2026-02-24T00:45:22","slug":"evidence-for-heightened-genetic-instability-in-precancerous-spasmolytic-polypeptide-expressing-gastric-glands","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2019\/03\/26\/evidence-for-heightened-genetic-instability-in-precancerous-spasmolytic-polypeptide-expressing-gastric-glands\/","title":{"rendered":"Evidence for Heightened Genetic Instability in Precancerous Spasmolytic Polypeptide Expressing Gastric Glands (Contributed by Dr. Yan Guo)"},"content":{"rendered":"<p>Spasmolytic polypeptide expressing metaplasia (SPEM) is present in more than 90% of resected gastric cancer tissues. However, although widely regarded as a pre-cancerous tissue, its genetic characteristics have not been well studied. In this work, we show for the first time that elevated genetic instability is a critical property of SPEM cells (TFF2 positive cells in SPEM glands) in both <em>H. felis<\/em>-infected mouse models and clinical samples. Unexpectedly, we also found that TFF2 negative cells in the same SPEM glands also exhibit substantial genetic instability. These results implicate stem cells of the SPEM glands as potential key players in carcinogenesis.<\/p>\n<p>Figure. Extensive MSI was found in SPEM cells and TFF2 negative cells of the mouse model infected with H. felis. (A) A detailed view of the experimental workflow. (B) Four sub-segments of SPEM cells and four sub-segments of TFF2 negative cells in SPEM gland 1 from H. felis-infected mouse (15 months) were isolated with laser microdissection. (C) The length variations of microsatellite markers in these 8 isolated sug-segmants detected with capillary electrophoresis. Bar = 150 \u00b5m (<a href=\"https:\/\/jmg.bmj.com\/content\/early\/2019\/03\/15\/jmedgenet-2018-105752\">https:\/\/jmg.bmj.com\/content\/early\/2019\/03\/15\/jmedgenet-2018-105752<\/a> )<\/p>\n<p><a href=\"https:\/\/blogs.bmj.com\/jmg\/2019\/03\/26\/evidence-for-heightened-genetic-instability-in-precancerous-spasmolytic-polypeptide-expressing-gastric-glands\/figure-1-revised-s\/\" rel=\"attachment wp-att-1256\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-1256\" src=\"https:\/\/blogs.bmj.com\/jmg\/files\/2019\/03\/figure-1-revised-s-287x300.jpg\" alt=\"\" width=\"287\" height=\"300\" srcset=\"https:\/\/blogs.bmj.com\/jmg\/files\/2019\/03\/figure-1-revised-s-287x300.jpg 287w, https:\/\/blogs.bmj.com\/jmg\/files\/2019\/03\/figure-1-revised-s-768x802.jpg 768w, https:\/\/blogs.bmj.com\/jmg\/files\/2019\/03\/figure-1-revised-s-981x1024.jpg 981w, https:\/\/blogs.bmj.com\/jmg\/files\/2019\/03\/figure-1-revised-s-640x668.jpg 640w\" sizes=\"auto, (max-width: 287px) 100vw, 287px\" \/><\/a><!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Spasmolytic polypeptide expressing metaplasia (SPEM) is present in more than 90% of resected gastric cancer tissues. However, although widely regarded as a pre-cancerous tissue, its genetic characteristics have not been well studied. In this work, we show for the first time that elevated genetic instability is a critical property of SPEM cells (TFF2 positive cells [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2019\/03\/26\/evidence-for-heightened-genetic-instability-in-precancerous-spasmolytic-polypeptide-expressing-gastric-glands\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1255","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Evidence for Heightened Genetic Instability in Precancerous Spasmolytic Polypeptide Expressing Gastric Glands (Contributed by Dr. Yan Guo) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2019\/03\/26\/evidence-for-heightened-genetic-instability-in-precancerous-spasmolytic-polypeptide-expressing-gastric-glands\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Evidence for Heightened Genetic Instability in Precancerous Spasmolytic Polypeptide Expressing Gastric Glands (Contributed by Dr. Yan Guo) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Spasmolytic polypeptide expressing metaplasia (SPEM) is present in more than 90% of resected gastric cancer tissues. However, although widely regarded as a pre-cancerous tissue, its genetic characteristics have not been well studied. In this work, we show for the first time that elevated genetic instability is a critical property of SPEM cells (TFF2 positive cells [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2019\/03\/26\/evidence-for-heightened-genetic-instability-in-precancerous-spasmolytic-polypeptide-expressing-gastric-glands\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2019-03-26T14:18:36+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-24T00:45:22+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/blogs.bmj.com\/jmg\/files\/2019\/03\/figure-1-revised-s.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2100\" \/>\n\t<meta property=\"og:image:height\" content=\"2193\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2019\\\/03\\\/26\\\/evidence-for-heightened-genetic-instability-in-precancerous-spasmolytic-polypeptide-expressing-gastric-glands\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2019\\\/03\\\/26\\\/evidence-for-heightened-genetic-instability-in-precancerous-spasmolytic-polypeptide-expressing-gastric-glands\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Evidence for Heightened Genetic Instability in Precancerous Spasmolytic Polypeptide Expressing Gastric Glands (Contributed by Dr. Yan Guo)\",\"datePublished\":\"2019-03-26T14:18:36+00:00\",\"dateModified\":\"2026-02-24T00:45:22+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2019\\\/03\\\/26\\\/evidence-for-heightened-genetic-instability-in-precancerous-spasmolytic-polypeptide-expressing-gastric-glands\\\/\"},\"wordCount\":195,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2019\\\/03\\\/26\\\/evidence-for-heightened-genetic-instability-in-precancerous-spasmolytic-polypeptide-expressing-gastric-glands\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2019\\\/03\\\/figure-1-revised-s-287x300.jpg\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2019\\\/03\\\/26\\\/evidence-for-heightened-genetic-instability-in-precancerous-spasmolytic-polypeptide-expressing-gastric-glands\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2019\\\/03\\\/26\\\/evidence-for-heightened-genetic-instability-in-precancerous-spasmolytic-polypeptide-expressing-gastric-glands\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2019\\\/03\\\/26\\\/evidence-for-heightened-genetic-instability-in-precancerous-spasmolytic-polypeptide-expressing-gastric-glands\\\/\",\"name\":\"Evidence for Heightened Genetic Instability in Precancerous Spasmolytic Polypeptide Expressing Gastric Glands (Contributed by Dr. Yan Guo) - 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