{"id":1210,"date":"2018-11-21T20:09:29","date_gmt":"2018-11-21T20:09:29","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=1210"},"modified":"2026-02-24T15:32:25","modified_gmt":"2026-02-24T15:32:25","slug":"mapping-of-breakpoints-in-balanced-chromosomal-translocations-by-shallow-whole-genome-sequencing-points-to-efna5-bahd1-and-ppp2r5e-as-novel-candidates-for-genes-causing-human-mendelian-disorders","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2018\/11\/21\/mapping-of-breakpoints-in-balanced-chromosomal-translocations-by-shallow-whole-genome-sequencing-points-to-efna5-bahd1-and-ppp2r5e-as-novel-candidates-for-genes-causing-human-mendelian-disorders\/","title":{"rendered":"Mapping of breakpoints in balanced chromosomal translocations by shallow whole genome sequencing points to EFNA5, BAHD1 and PPP2R5E as novel candidates for genes causing human Mendelian disorders (Contributed by Prof. dr hab. Rafal Ploski)"},"content":{"rendered":"

Mapping breakpoints in patients with de novo balanced chromosomal translocation (BCTs) offers a unique possibility for identification of new genes causing human monogenic disorders, even when only single patients are studied. Historically, solving the exact structure of BCTs was laborious, but with the emergence of next generation sequencing (NGS) it became possible to rapidly map the breakpoints with a resolution up to 1bp. Using shallow mate pair genomic sequencing we report the structure of BCTs in 9 probands with special emphasis on patients with disrupted genes that so far have not been linked to human disorders (EFNA5, BAHD1 and PPP2R5E). (https:\/\/jmg.bmj.com\/content\/early\/2018\/10\/23\/jmedgenet-2018-105527<\/a> )<\/p>\n","protected":false},"excerpt":{"rendered":"

Mapping breakpoints in patients with de novo balanced chromosomal translocation (BCTs) offers a unique possibility for identification of new genes causing human monogenic disorders, even when only single patients are studied. Historically, solving the exact structure of BCTs was laborious, but with the emergence of next generation sequencing (NGS) it became possible to rapidly map […]<\/p>\n

Read More…<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1210","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"\nMapping of breakpoints in balanced chromosomal translocations by shallow whole genome sequencing points to EFNA5, BAHD1 and PPP2R5E as novel candidates for genes causing human Mendelian disorders (Contributed by Prof. dr hab. Rafal Ploski) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2018\/11\/21\/mapping-of-breakpoints-in-balanced-chromosomal-translocations-by-shallow-whole-genome-sequencing-points-to-efna5-bahd1-and-ppp2r5e-as-novel-candidates-for-genes-causing-human-mendelian-disorders\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mapping of breakpoints in balanced chromosomal translocations by shallow whole genome sequencing points to EFNA5, BAHD1 and PPP2R5E as novel candidates for genes causing human Mendelian disorders (Contributed by Prof. dr hab. 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Historically, solving the exact structure of BCTs was laborious, but with the emergence of next generation sequencing (NGS) it became possible to rapidly map [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2018\/11\/21\/mapping-of-breakpoints-in-balanced-chromosomal-translocations-by-shallow-whole-genome-sequencing-points-to-efna5-bahd1-and-ppp2r5e-as-novel-candidates-for-genes-causing-human-mendelian-disorders\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2018-11-21T20:09:29+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-24T15:32:25+00:00\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2018\\\/11\\\/21\\\/mapping-of-breakpoints-in-balanced-chromosomal-translocations-by-shallow-whole-genome-sequencing-points-to-efna5-bahd1-and-ppp2r5e-as-novel-candidates-for-genes-causing-human-mendelian-disorders\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2018\\\/11\\\/21\\\/mapping-of-breakpoints-in-balanced-chromosomal-translocations-by-shallow-whole-genome-sequencing-points-to-efna5-bahd1-and-ppp2r5e-as-novel-candidates-for-genes-causing-human-mendelian-disorders\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Mapping of breakpoints in balanced chromosomal translocations by shallow whole genome sequencing points to EFNA5, BAHD1 and PPP2R5E as novel candidates for genes causing human Mendelian disorders (Contributed by Prof. dr hab. 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