{"id":1183,"date":"2018-10-04T18:22:14","date_gmt":"2018-10-04T18:22:14","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=1183"},"modified":"2026-02-24T15:38:08","modified_gmt":"2026-02-24T15:38:08","slug":"progression-from-islet-autoimmunity-to-clinical-type-1-diabetes-is-influenced-by-genetic-factors-results-from-the-prospective-teddy-study","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2018\/10\/04\/progression-from-islet-autoimmunity-to-clinical-type-1-diabetes-is-influenced-by-genetic-factors-results-from-the-prospective-teddy-study\/","title":{"rendered":"Progression from islet autoimmunity to clinical type 1 diabetes is influenced by genetic factors: results from the prospective TEDDY study (Contributed by Dr. Andreas Beyerlein)"},"content":{"rendered":"

Type 1 diabetes, which is the most common metabolic disease in children and
\nadolescents, begins with a pre-clinical phase which is defined by the
\npresence of islet autoantibodies. This pre-clinical phase is variable in
\nduration with onset of clinical diabetes occurring months to decades after
\nthe appearance of islet autoantibodies. In this study, we found that a
\ngenetic risk score that had previously been shown to predict islet
\nautoimmunity also predicts disease progression. The risk score may therefore
\nbe used to identify subgroups with fast or slow progression in clinical
\nstudies. (https:\/\/jmg.bmj.com\/content\/early\/2018\/10\/03\/jmedgenet-2018-105532<\/a> )<\/p>\n

\"\"<\/a><\/p>\n

Cumulative risks of (A) development of multiple islet autoantibodies after first appearance of any autoantibodies, (B) development of type 1 diabetes after first appearance of any autoantibodies and (C) development of type 1 diabetes after first appearance of multiple autoantibodies, in children with the HLA DR3\/DR4-DQ8 or the HLA DR4-DQ8\/DR4-DQ8 genotype. P values were calculated using log-rank tests. The groups were defined by quartiles of the genetic risk score (green: lower quartile; blue: two medium quartiles; orange: upper quartile). HLA, human leucocyte antigen.<\/p>\n","protected":false},"excerpt":{"rendered":"

Type 1 diabetes, which is the most common metabolic disease in children and adolescents, begins with a pre-clinical phase which is defined by the presence of islet autoantibodies. This pre-clinical phase is variable in duration with onset of clinical diabetes occurring months to decades after the appearance of islet autoantibodies. In this study, we found […]<\/p>\n

Read More…<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1183","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"\nProgression from islet autoimmunity to clinical type 1 diabetes is influenced by genetic factors: results from the prospective TEDDY study (Contributed by Dr. Andreas Beyerlein) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2018\/10\/04\/progression-from-islet-autoimmunity-to-clinical-type-1-diabetes-is-influenced-by-genetic-factors-results-from-the-prospective-teddy-study\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Progression from islet autoimmunity to clinical type 1 diabetes is influenced by genetic factors: results from the prospective TEDDY study (Contributed by Dr. Andreas Beyerlein) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Type 1 diabetes, which is the most common metabolic disease in children and adolescents, begins with a pre-clinical phase which is defined by the presence of islet autoantibodies. 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