{"id":1152,"date":"2018-07-09T18:27:57","date_gmt":"2018-07-09T18:27:57","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=1152"},"modified":"2026-02-24T15:51:09","modified_gmt":"2026-02-24T15:51:09","slug":"fine-mapping-mhc-associations-in-graves-disease-and-its-clinical-subtypes-in-han-chinese","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2018\/07\/09\/fine-mapping-mhc-associations-in-graves-disease-and-its-clinical-subtypes-in-han-chinese\/","title":{"rendered":"Fine mapping MHC associations in Graves\u2019 disease and its clinical subtypes in Han Chinese (Contributed by Dr. Xun Chu)"},"content":{"rendered":"

The classical human leukocyte antigen (HLA) genes were the most important genetic determinant for Graves\u2019 disease (GD). We applied imputation to thoroughly investigate the MHC<\/em> associations with GD down to the amino acid level of classical HLA genes in 1,468 GD patients and 1,490 controls of Han Chinese. We observed the top association signal at HLA-DP\u03b21 position 205 and HLA-DPA1*02:02 was the strongest association among the classical HLA<\/em> alleles, which was in perfect LD with HLA-DP\u03b11 residue Met11. Conditional analysis revealed four amino acid positions could account for most HLA association with GD in Han Chinese. HLA-DP\u03b11 Met11 might explain the risk heterogeneity between two clinical subtypes of GD, namely persistent TRAb positive (pTRAb+) group after anti-thyroid drug therapy and \u201cnon-persistent TRAb positive\u201d (pTRAb-) group after ATD therapy. (https:\/\/jmg.bmj.com\/content\/early\/2018\/07\/09\/jmedgenet-2017-105146<\/a> )<\/p>\n

\"\"<\/a><\/p>\n

The most strongly associated amino acid positions of classical HLA genes with Graves\u2019 disease susceptibility in Han Chinese<\/p>\n","protected":false},"excerpt":{"rendered":"

The classical human leukocyte antigen (HLA) genes were the most important genetic determinant for Graves\u2019 disease (GD). We applied imputation to thoroughly investigate the MHC associations with GD down to the amino acid level of classical HLA genes in 1,468 GD patients and 1,490 controls of Han Chinese. We observed the top association signal at […]<\/p>\n

Read More…<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1152","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"\nFine mapping MHC associations in Graves\u2019 disease and its clinical subtypes in Han Chinese (Contributed by Dr. Xun Chu) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2018\/07\/09\/fine-mapping-mhc-associations-in-graves-disease-and-its-clinical-subtypes-in-han-chinese\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Fine mapping MHC associations in Graves\u2019 disease and its clinical subtypes in Han Chinese (Contributed by Dr. Xun Chu) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"The classical human leukocyte antigen (HLA) genes were the most important genetic determinant for Graves\u2019 disease (GD). We applied imputation to thoroughly investigate the MHC associations with GD down to the amino acid level of classical HLA genes in 1,468 GD patients and 1,490 controls of Han Chinese. 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