{"id":1094,"date":"2018-02-10T19:28:10","date_gmt":"2018-02-10T19:28:10","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=1094"},"modified":"2026-02-24T16:00:31","modified_gmt":"2026-02-24T16:00:31","slug":"evidence-for-genetic-anticipation-in-von-hippel-lindau-syndrome","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2018\/02\/10\/evidence-for-genetic-anticipation-in-von-hippel-lindau-syndrome\/","title":{"rendered":"Evidence for genetic anticipation in von Hippel-Lindau syndrome (Contributed by Kalene van Engelen)"},"content":{"rendered":"<p style=\"margin: 0in;margin-bottom: .0001pt;background: white\"><span style=\"font-family: 'Calibri',sans-serif;color: black\">Von Hippel-Lindau syndrome (vHL) is a hereditary cancer syndrome that predisposes to developing tumours in multiple organs. Initiating tumour surveillance before tumours are likely to occur is critical for optimal patient outcomes. In our study, we found significantly earlier ages of tumour onset in children with vHL compared to their vHL parents, indicating vHL may exhibit genetic anticipation (where symptoms present at younger ages in subsequent generations). Unlike dyskeratosis congenita, another cancer syndrome, anticipation in vHL was not associated with telomere shortening. Our observations support modifying surveillance guidelines to account for earlier ages of onset in younger generations with vHL. (<a href=\"http:\/\/jmg.bmj.com\/content\/early\/2018\/02\/06\/jmedgenet-2017-104882\">http:\/\/jmg.bmj.com\/content\/early\/2018\/02\/06\/jmedgenet-2017-104882<\/a> )<\/span><\/p>\n<p><!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Von Hippel-Lindau syndrome (vHL) is a hereditary cancer syndrome that predisposes to developing tumours in multiple organs. Initiating tumour surveillance before tumours are likely to occur is critical for optimal patient outcomes. In our study, we found significantly earlier ages of tumour onset in children with vHL compared to their vHL parents, indicating vHL may [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2018\/02\/10\/evidence-for-genetic-anticipation-in-von-hippel-lindau-syndrome\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1094","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Evidence for genetic anticipation in von Hippel-Lindau syndrome (Contributed by Kalene van Engelen) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2018\/02\/10\/evidence-for-genetic-anticipation-in-von-hippel-lindau-syndrome\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Evidence for genetic anticipation in von Hippel-Lindau syndrome (Contributed by Kalene van Engelen) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Von Hippel-Lindau syndrome (vHL) is a hereditary cancer syndrome that predisposes to developing tumours in multiple organs. Initiating tumour surveillance before tumours are likely to occur is critical for optimal patient outcomes. In our study, we found significantly earlier ages of tumour onset in children with vHL compared to their vHL parents, indicating vHL may [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2018\/02\/10\/evidence-for-genetic-anticipation-in-von-hippel-lindau-syndrome\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2018-02-10T19:28:10+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-24T16:00:31+00:00\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2018\\\/02\\\/10\\\/evidence-for-genetic-anticipation-in-von-hippel-lindau-syndrome\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2018\\\/02\\\/10\\\/evidence-for-genetic-anticipation-in-von-hippel-lindau-syndrome\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Evidence for genetic anticipation in von Hippel-Lindau syndrome (Contributed by Kalene van Engelen)\",\"datePublished\":\"2018-02-10T19:28:10+00:00\",\"dateModified\":\"2026-02-24T16:00:31+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2018\\\/02\\\/10\\\/evidence-for-genetic-anticipation-in-von-hippel-lindau-syndrome\\\/\"},\"wordCount\":121,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2018\\\/02\\\/10\\\/evidence-for-genetic-anticipation-in-von-hippel-lindau-syndrome\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2018\\\/02\\\/10\\\/evidence-for-genetic-anticipation-in-von-hippel-lindau-syndrome\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2018\\\/02\\\/10\\\/evidence-for-genetic-anticipation-in-von-hippel-lindau-syndrome\\\/\",\"name\":\"Evidence for genetic anticipation in von Hippel-Lindau syndrome (Contributed by Kalene van Engelen) - 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