{"id":1067,"date":"2017-12-23T19:24:31","date_gmt":"2017-12-23T19:24:31","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=1067"},"modified":"2026-02-24T16:03:46","modified_gmt":"2026-02-24T16:03:46","slug":"evaluation-of-the-relative-effectiveness-of-the-2017-updated-manchester-scoring-system-for-predicting-brca1-2-mutations-in-a-southeast-asian-country","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2017\/12\/23\/evaluation-of-the-relative-effectiveness-of-the-2017-updated-manchester-scoring-system-for-predicting-brca1-2-mutations-in-a-southeast-asian-country\/","title":{"rendered":"Evaluation of the relative effectiveness of the 2017 updated Manchester scoring system for predicting BRCA1\/2 mutations in a Southeast Asian country (Contributed by Mr. Winston Chew)"},"content":{"rendered":"<p><em>BRCA1\/2<\/em> mutations are responsible for a significant portion of hereditary breast and ovarian cancers. Identifying patients with <em>BRCA<\/em>1\/2 mutations allows for gene-directed surveillance and intervention. The Manchester Scoring System (MSS) is a quick and easy algorithm to identify patients with a likelihood of having a <em>BRCA1\/2<\/em> mutation. Recently, a third iteration of MSS (MSS3), validated by an European cohort, showed greater sensitivity and specificity over previous MSS models. This Singapore study, showed similar improvements in MMS3 for an ethnically diverse population. Clinicans can use MSS3 to identify patients who may benefit from germline <em>BRCA1\/2<\/em> testing. (<a href=\"http:\/\/jmg.bmj.com\/content\/early\/2017\/12\/23\/jmedgenet-2017-105073\">http:\/\/jmg.bmj.com\/content\/early\/2017\/12\/23\/jmedgenet-2017-105073<\/a> )<\/p>\n<p><a href=\"https:\/\/blogs.bmj.com\/jmg\/files\/2017\/12\/Untitled.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-1068\" src=\"https:\/\/blogs.bmj.com\/jmg\/files\/2017\/12\/Untitled-300x168.jpg\" alt=\"\" width=\"300\" height=\"168\" srcset=\"https:\/\/blogs.bmj.com\/jmg\/files\/2017\/12\/Untitled-300x168.jpg 300w, https:\/\/blogs.bmj.com\/jmg\/files\/2017\/12\/Untitled-768x431.jpg 768w, https:\/\/blogs.bmj.com\/jmg\/files\/2017\/12\/Untitled-1024x574.jpg 1024w, https:\/\/blogs.bmj.com\/jmg\/files\/2017\/12\/Untitled.jpg 1298w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>BRCA1\/2 mutations are responsible for a significant portion of hereditary breast and ovarian cancers. Identifying patients with BRCA1\/2 mutations allows for gene-directed surveillance and intervention. The Manchester Scoring System (MSS) is a quick and easy algorithm to identify patients with a likelihood of having a BRCA1\/2 mutation. Recently, a third iteration of MSS (MSS3), validated [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/jmg\/2017\/12\/23\/evaluation-of-the-relative-effectiveness-of-the-2017-updated-manchester-scoring-system-for-predicting-brca1-2-mutations-in-a-southeast-asian-country\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1067","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Evaluation of the relative effectiveness of the 2017 updated Manchester scoring system for predicting BRCA1\/2 mutations in a Southeast Asian country (Contributed by Mr. Winston Chew) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2017\/12\/23\/evaluation-of-the-relative-effectiveness-of-the-2017-updated-manchester-scoring-system-for-predicting-brca1-2-mutations-in-a-southeast-asian-country\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Evaluation of the relative effectiveness of the 2017 updated Manchester scoring system for predicting BRCA1\/2 mutations in a Southeast Asian country (Contributed by Mr. Winston Chew) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"BRCA1\/2 mutations are responsible for a significant portion of hereditary breast and ovarian cancers. Identifying patients with BRCA1\/2 mutations allows for gene-directed surveillance and intervention. The Manchester Scoring System (MSS) is a quick and easy algorithm to identify patients with a likelihood of having a BRCA1\/2 mutation. Recently, a third iteration of MSS (MSS3), validated [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2017\/12\/23\/evaluation-of-the-relative-effectiveness-of-the-2017-updated-manchester-scoring-system-for-predicting-brca1-2-mutations-in-a-southeast-asian-country\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2017-12-23T19:24:31+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-24T16:03:46+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/blogs.bmj.com\/jmg\/files\/2017\/12\/Untitled.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1298\" \/>\n\t<meta property=\"og:image:height\" content=\"728\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2017\\\/12\\\/23\\\/evaluation-of-the-relative-effectiveness-of-the-2017-updated-manchester-scoring-system-for-predicting-brca1-2-mutations-in-a-southeast-asian-country\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2017\\\/12\\\/23\\\/evaluation-of-the-relative-effectiveness-of-the-2017-updated-manchester-scoring-system-for-predicting-brca1-2-mutations-in-a-southeast-asian-country\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Evaluation of the relative effectiveness of the 2017 updated Manchester scoring system for predicting BRCA1\\\/2 mutations in a Southeast Asian country (Contributed by Mr. Winston Chew)\",\"datePublished\":\"2017-12-23T19:24:31+00:00\",\"dateModified\":\"2026-02-24T16:03:46+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2017\\\/12\\\/23\\\/evaluation-of-the-relative-effectiveness-of-the-2017-updated-manchester-scoring-system-for-predicting-brca1-2-mutations-in-a-southeast-asian-country\\\/\"},\"wordCount\":128,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2017\\\/12\\\/23\\\/evaluation-of-the-relative-effectiveness-of-the-2017-updated-manchester-scoring-system-for-predicting-brca1-2-mutations-in-a-southeast-asian-country\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2017\\\/12\\\/Untitled-300x168.jpg\",\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2017\\\/12\\\/23\\\/evaluation-of-the-relative-effectiveness-of-the-2017-updated-manchester-scoring-system-for-predicting-brca1-2-mutations-in-a-southeast-asian-country\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2017\\\/12\\\/23\\\/evaluation-of-the-relative-effectiveness-of-the-2017-updated-manchester-scoring-system-for-predicting-brca1-2-mutations-in-a-southeast-asian-country\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2017\\\/12\\\/23\\\/evaluation-of-the-relative-effectiveness-of-the-2017-updated-manchester-scoring-system-for-predicting-brca1-2-mutations-in-a-southeast-asian-country\\\/\",\"name\":\"Evaluation of the relative effectiveness of the 2017 updated Manchester scoring system for predicting BRCA1\\\/2 mutations in a Southeast Asian country (Contributed by Mr. Winston Chew) - 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His research applies human genetics and multi-omics to complex and pediatric diseases, including GWAS, polygenic risk scores (PRS), single-cell transcriptomics, and integrative genomics to support precision medicine and clinical translation.\",\"sameAs\":[\"https:\\\/\\\/x.com\\\/HuiQiQu\"],\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/author\\\/hqiqu\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Evaluation of the relative effectiveness of the 2017 updated Manchester scoring system for predicting BRCA1\/2 mutations in a Southeast Asian country (Contributed by Mr. Winston Chew) - JMG Contact blog","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/blogs.bmj.com\/jmg\/2017\/12\/23\/evaluation-of-the-relative-effectiveness-of-the-2017-updated-manchester-scoring-system-for-predicting-brca1-2-mutations-in-a-southeast-asian-country\/","og_locale":"en_US","og_type":"article","og_title":"Evaluation of the relative effectiveness of the 2017 updated Manchester scoring system for predicting BRCA1\/2 mutations in a Southeast Asian country (Contributed by Mr. Winston Chew) - JMG Contact blog","og_description":"BRCA1\/2 mutations are responsible for a significant portion of hereditary breast and ovarian cancers. 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