{"id":1060,"date":"2017-11-18T19:41:27","date_gmt":"2017-11-18T19:41:27","guid":{"rendered":"https:\/\/blogs.bmj.com\/jmg\/?p=1060"},"modified":"2026-02-24T16:05:20","modified_gmt":"2026-02-24T16:05:20","slug":"genome-wide-association-study-of-telomere-length-among-south-asians-identifies-a-second-rtel1-association-signal","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/jmg\/2017\/11\/18\/genome-wide-association-study-of-telomere-length-among-south-asians-identifies-a-second-rtel1-association-signal\/","title":{"rendered":"Genome-wide association study of telomere length among South Asians identifies a second RTEL1 association signal (Contributed by Dayana A. Delgado)"},"content":{"rendered":"

Telomeres are DNA-protein complexes that protect chromosome ends. Leukocyte telomere length (LTL) is a potential biomarker of aging and risk for age-related disease. Prior genome-wide association (GWA) studies have identified 10 inherited genetic variants that influence LTL in populations of European ancestry. However, there is evidence of considerable population differences in LTL. In this GWA study of LTL among Bangladeshi individuals, we observe two association signals observed in prior GWA studies (i.e., TERC<\/em> and TERT<\/em>).\u00a0 We also find evidence for a novel association in the RTEL1<\/em> region, which is distinct from the prior association reported in this region. (http:\/\/jmg.bmj.com\/content\/early\/2017\/11\/18\/jmedgenet-2017-104922<\/a> )<\/p>\n","protected":false},"excerpt":{"rendered":"

Telomeres are DNA-protein complexes that protect chromosome ends. Leukocyte telomere length (LTL) is a potential biomarker of aging and risk for age-related disease. Prior genome-wide association (GWA) studies have identified 10 inherited genetic variants that influence LTL in populations of European ancestry. However, there is evidence of considerable population differences in LTL. In this GWA […]<\/p>\n

Read More…<\/a><\/p>\n","protected":false},"author":123,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1060","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"\nGenome-wide association study of telomere length among South Asians identifies a second RTEL1 association signal (Contributed by Dayana A. Delgado) - JMG Contact blog<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/jmg\/2017\/11\/18\/genome-wide-association-study-of-telomere-length-among-south-asians-identifies-a-second-rtel1-association-signal\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Genome-wide association study of telomere length among South Asians identifies a second RTEL1 association signal (Contributed by Dayana A. Delgado) - JMG Contact blog\" \/>\n<meta property=\"og:description\" content=\"Telomeres are DNA-protein complexes that protect chromosome ends. Leukocyte telomere length (LTL) is a potential biomarker of aging and risk for age-related disease. Prior genome-wide association (GWA) studies have identified 10 inherited genetic variants that influence LTL in populations of European ancestry. However, there is evidence of considerable population differences in LTL. In this GWA [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/jmg\/2017\/11\/18\/genome-wide-association-study-of-telomere-length-among-south-asians-identifies-a-second-rtel1-association-signal\/\" \/>\n<meta property=\"og:site_name\" content=\"JMG Contact blog\" \/>\n<meta property=\"article:published_time\" content=\"2017-11-18T19:41:27+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-24T16:05:20+00:00\" \/>\n<meta name=\"author\" content=\"hqqu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@HuiQiQu\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"hqqu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2017\\\/11\\\/18\\\/genome-wide-association-study-of-telomere-length-among-south-asians-identifies-a-second-rtel1-association-signal\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2017\\\/11\\\/18\\\/genome-wide-association-study-of-telomere-length-among-south-asians-identifies-a-second-rtel1-association-signal\\\/\"},\"author\":{\"name\":\"hqqu\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\"},\"headline\":\"Genome-wide association study of telomere length among South Asians identifies a second RTEL1 association signal (Contributed by Dayana A. Delgado)\",\"datePublished\":\"2017-11-18T19:41:27+00:00\",\"dateModified\":\"2026-02-24T16:05:20+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2017\\\/11\\\/18\\\/genome-wide-association-study-of-telomere-length-among-south-asians-identifies-a-second-rtel1-association-signal\\\/\"},\"wordCount\":126,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2017\\\/11\\\/18\\\/genome-wide-association-study-of-telomere-length-among-south-asians-identifies-a-second-rtel1-association-signal\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2017\\\/11\\\/18\\\/genome-wide-association-study-of-telomere-length-among-south-asians-identifies-a-second-rtel1-association-signal\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2017\\\/11\\\/18\\\/genome-wide-association-study-of-telomere-length-among-south-asians-identifies-a-second-rtel1-association-signal\\\/\",\"name\":\"Genome-wide association study of telomere length among South Asians identifies a second RTEL1 association signal (Contributed by Dayana A. Delgado) - JMG Contact blog\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#website\"},\"datePublished\":\"2017-11-18T19:41:27+00:00\",\"dateModified\":\"2026-02-24T16:05:20+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2017\\\/11\\\/18\\\/genome-wide-association-study-of-telomere-length-among-south-asians-identifies-a-second-rtel1-association-signal\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2017\\\/11\\\/18\\\/genome-wide-association-study-of-telomere-length-among-south-asians-identifies-a-second-rtel1-association-signal\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/2017\\\/11\\\/18\\\/genome-wide-association-study-of-telomere-length-among-south-asians-identifies-a-second-rtel1-association-signal\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Genome-wide association study of telomere length among South Asians identifies a second RTEL1 association signal (Contributed by Dayana A. Delgado)\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#website\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/\",\"name\":\"JMG Contact blog\",\"description\":\"JMG Contact blog\",\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#organization\",\"name\":\"JMG Contact blog\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2017\\\/10\\\/blog-logo-jmg.png\",\"contentUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/files\\\/2017\\\/10\\\/blog-logo-jmg.png\",\"width\":300,\"height\":34,\"caption\":\"JMG Contact blog\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/#\\\/schema\\\/person\\\/be0250f8d5b52412c3e7c222dabd591b\",\"name\":\"hqqu\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g\",\"caption\":\"hqqu\"},\"description\":\"Huiqi Qu has a background as a physician trained in internal medicine and a PhD in Experimental Medicine (Endocrinology). His research applies human genetics and multi-omics to complex and pediatric diseases, including GWAS, polygenic risk scores (PRS), single-cell transcriptomics, and integrative genomics to support precision medicine and clinical translation.\",\"sameAs\":[\"https:\\\/\\\/x.com\\\/HuiQiQu\"],\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/jmg\\\/author\\\/hqiqu\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Genome-wide association study of telomere length among South Asians identifies a second RTEL1 association signal (Contributed by Dayana A. Delgado) - JMG Contact blog","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/blogs.bmj.com\/jmg\/2017\/11\/18\/genome-wide-association-study-of-telomere-length-among-south-asians-identifies-a-second-rtel1-association-signal\/","og_locale":"en_US","og_type":"article","og_title":"Genome-wide association study of telomere length among South Asians identifies a second RTEL1 association signal (Contributed by Dayana A. Delgado) - JMG Contact blog","og_description":"Telomeres are DNA-protein complexes that protect chromosome ends. Leukocyte telomere length (LTL) is a potential biomarker of aging and risk for age-related disease. Prior genome-wide association (GWA) studies have identified 10 inherited genetic variants that influence LTL in populations of European ancestry. However, there is evidence of considerable population differences in LTL. In this GWA [...]Read More...","og_url":"https:\/\/blogs.bmj.com\/jmg\/2017\/11\/18\/genome-wide-association-study-of-telomere-length-among-south-asians-identifies-a-second-rtel1-association-signal\/","og_site_name":"JMG Contact blog","article_published_time":"2017-11-18T19:41:27+00:00","article_modified_time":"2026-02-24T16:05:20+00:00","author":"hqqu","twitter_card":"summary_large_image","twitter_creator":"@HuiQiQu","twitter_misc":{"Written by":"hqqu","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/blogs.bmj.com\/jmg\/2017\/11\/18\/genome-wide-association-study-of-telomere-length-among-south-asians-identifies-a-second-rtel1-association-signal\/#article","isPartOf":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2017\/11\/18\/genome-wide-association-study-of-telomere-length-among-south-asians-identifies-a-second-rtel1-association-signal\/"},"author":{"name":"hqqu","@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/person\/be0250f8d5b52412c3e7c222dabd591b"},"headline":"Genome-wide association study of telomere length among South Asians identifies a second RTEL1 association signal (Contributed by Dayana A. Delgado)","datePublished":"2017-11-18T19:41:27+00:00","dateModified":"2026-02-24T16:05:20+00:00","mainEntityOfPage":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2017\/11\/18\/genome-wide-association-study-of-telomere-length-among-south-asians-identifies-a-second-rtel1-association-signal\/"},"wordCount":126,"commentCount":0,"publisher":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#organization"},"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/blogs.bmj.com\/jmg\/2017\/11\/18\/genome-wide-association-study-of-telomere-length-among-south-asians-identifies-a-second-rtel1-association-signal\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/blogs.bmj.com\/jmg\/2017\/11\/18\/genome-wide-association-study-of-telomere-length-among-south-asians-identifies-a-second-rtel1-association-signal\/","url":"https:\/\/blogs.bmj.com\/jmg\/2017\/11\/18\/genome-wide-association-study-of-telomere-length-among-south-asians-identifies-a-second-rtel1-association-signal\/","name":"Genome-wide association study of telomere length among South Asians identifies a second RTEL1 association signal (Contributed by Dayana A. Delgado) - JMG Contact blog","isPartOf":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#website"},"datePublished":"2017-11-18T19:41:27+00:00","dateModified":"2026-02-24T16:05:20+00:00","breadcrumb":{"@id":"https:\/\/blogs.bmj.com\/jmg\/2017\/11\/18\/genome-wide-association-study-of-telomere-length-among-south-asians-identifies-a-second-rtel1-association-signal\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/blogs.bmj.com\/jmg\/2017\/11\/18\/genome-wide-association-study-of-telomere-length-among-south-asians-identifies-a-second-rtel1-association-signal\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/blogs.bmj.com\/jmg\/2017\/11\/18\/genome-wide-association-study-of-telomere-length-among-south-asians-identifies-a-second-rtel1-association-signal\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/blogs.bmj.com\/jmg\/"},{"@type":"ListItem","position":2,"name":"Genome-wide association study of telomere length among South Asians identifies a second RTEL1 association signal (Contributed by Dayana A. Delgado)"}]},{"@type":"WebSite","@id":"https:\/\/blogs.bmj.com\/jmg\/#website","url":"https:\/\/blogs.bmj.com\/jmg\/","name":"JMG Contact blog","description":"JMG Contact blog","publisher":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/blogs.bmj.com\/jmg\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/blogs.bmj.com\/jmg\/#organization","name":"JMG Contact blog","url":"https:\/\/blogs.bmj.com\/jmg\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/logo\/image\/","url":"https:\/\/blogs.bmj.com\/jmg\/files\/2017\/10\/blog-logo-jmg.png","contentUrl":"https:\/\/blogs.bmj.com\/jmg\/files\/2017\/10\/blog-logo-jmg.png","width":300,"height":34,"caption":"JMG Contact blog"},"image":{"@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/blogs.bmj.com\/jmg\/#\/schema\/person\/be0250f8d5b52412c3e7c222dabd591b","name":"hqqu","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/920bc4e81500cde88def4bfd7775029cb154e422c5460b9cf80d5c47137d6f35?s=96&d=mm&r=g","caption":"hqqu"},"description":"Huiqi Qu has a background as a physician trained in internal medicine and a PhD in Experimental Medicine (Endocrinology). His research applies human genetics and multi-omics to complex and pediatric diseases, including GWAS, polygenic risk scores (PRS), single-cell transcriptomics, and integrative genomics to support precision medicine and clinical translation.","sameAs":["https:\/\/x.com\/HuiQiQu"],"url":"https:\/\/blogs.bmj.com\/jmg\/author\/hqiqu\/"}]}},"_links":{"self":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/1060","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/users\/123"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/comments?post=1060"}],"version-history":[{"count":0,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/posts\/1060\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/media?parent=1060"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/categories?post=1060"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.bmj.com\/jmg\/wp-json\/wp\/v2\/tags?post=1060"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}