{"id":219,"date":"2010-05-04T14:47:04","date_gmt":"2010-05-04T13:47:04","guid":{"rendered":"https:\/\/blogs.bmj.com\/heart-journalscan\/?p=219"},"modified":"2010-05-04T14:48:58","modified_gmt":"2010-05-04T13:48:58","slug":"coronary-arteries-form-from-reprogramming-of-venous-cells","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/heart\/2010\/05\/04\/coronary-arteries-form-from-reprogramming-of-venous-cells\/","title":{"rendered":"Coronary arteries form from reprogramming of venous cells"},"content":{"rendered":"<div id=\"_mcePaste\">\n<div id=\"_mcePaste\">\n<p class=\"MsoNormal\" style=\"text-align: justify\">The cellular and developmental origins of the coronary arteries remain relatively poorly studied; determining how coronary vessels arise during development, are maintained in adult life, and remodel under pathological conditions could further our understanding of diseases such as atherosclerosis.<\/p>\n<p class=\"MsoNormal\" style=\"text-align: justify\">In the paper Red-Horse et al. carried out anatomical and histological analysis of coronary vessel development during mouse embryogenesis by using endothelial markers.<span> <\/span>Coronary vessel progenitors were found to arise from angiogenic sprouts of the sinus venosus which then differentiate: invading cells differentiate into arteries and capillaries, while cells that remain on the surface differentiate into veins.<span> <\/span>Position-specific cardiac signals trigger the differentiation into arteries, capillaries or veins.<\/p>\n<p class=\"MsoNormal\" style=\"text-align: justify\">Conclusions:<\/p>\n<p class=\"MsoNormal\" style=\"text-align: justify\">This study redefines the conventional view that coronary vessels form from proepicardial cells that undergo an epithelial-to-mesenchymal transition.<span> <\/span>Understanding the process of coronary arterial development could in the future lead to alternative revascularisation strategies.<\/p>\n<p class=\"MsoNormal\" style=\"margin-left: 36.0pt;text-align: justify;text-indent: -18.0pt\"><span style=\"font-family: Symbol\" lang=\"EN-US\"><span>\u00b7<span> <\/span><\/span><\/span><span lang=\"EN-US\">Red-Horse K, Ueno H, Weissman IL, Krasnow MA. Coronary arteries form by developmental reprogramming of venous cells. Nature 2010, Mar 25;464(7288):549-53.<\/span><\/p>\n<\/div>\n<\/div>\n<p><!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The cellular and developmental origins of the coronary arteries remain relatively poorly studied; determining how coronary vessels arise during development, are maintained in adult life, and remodel under pathological conditions could further our understanding of diseases such as atherosclerosis. In the paper Red-Horse et al. carried out anatomical and histological analysis of coronary vessel development [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/heart\/2010\/05\/04\/coronary-arteries-form-from-reprogramming-of-venous-cells\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":103,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[288],"tags":[],"class_list":["post-219","post","type-post","status-publish","format-standard","hentry","category-molecular-cardiology"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Coronary arteries form from reprogramming of venous cells - Heart<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/heart\/2010\/05\/04\/coronary-arteries-form-from-reprogramming-of-venous-cells\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Coronary arteries form from reprogramming of venous cells - Heart\" \/>\n<meta property=\"og:description\" content=\"The cellular and developmental origins of the coronary arteries remain relatively poorly studied; determining how coronary vessels arise during development, are maintained in adult life, and remodel under pathological conditions could further our understanding of diseases such as atherosclerosis. 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