{"id":1575,"date":"2014-04-13T15:26:58","date_gmt":"2014-04-13T14:26:58","guid":{"rendered":"https:\/\/blogs.bmj.com\/heart-journalscan\/?p=1575"},"modified":"2015-11-12T16:48:16","modified_gmt":"2015-11-12T15:48:16","slug":"mesenchymal-stem-cells-may-improve-quality-of-life-for-patients-with-ischemic-cardiomyopathy","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/heart\/2014\/04\/13\/mesenchymal-stem-cells-may-improve-quality-of-life-for-patients-with-ischemic-cardiomyopathy\/","title":{"rendered":"Mesenchymal stem cells may improve quality of life for patients with ischemic cardiomyopathy"},"content":{"rendered":"<p>In this study, patients with chronic ischemic cardiomyopathy and EF &lt;50% on optimal medical therapy were randomized to autologous culture expanded mesenchymal cells (=22), autologous bone marrow mononuclear cells (n=22) or placebo vehicle (n=21) delivered by transendocardial stem cell injection (TESI). There were no serious adverse events among any patients undergoing a TESI procedure. Rates of major adverse cardiovascular events did not vary between groups. A possible signal of improved quality of life was observed following treatment with either of the cell types.\u00a0 At one year, a repeated measures model demonstrated the Minnesota Living with Heart Failure score had improved following treatment with mesenchymal (-6.3; 95% CI -15.0 to 2.4, P=.02) or bone marrow cells (-8.2; 95% CI -17.4 to 0.97, P=.005) but not in the placebo group (0.4; 95% CI -9.45 to 10.25, P=.38). Only mesenchymal cells decreased scar size as a percentage of the LV mass (-18.9%; 95% CI\u00a0 -30.4 to -7.4, P=.004).<!--more--><\/p>\n<p><b>Conclusion<\/b><\/p>\n<p>Transendocardial injection of both mesenchymal and bone marrow cells for ischemic cardiomyopathy was safe in this small initial trial.\u00a0 Signals of quality of life improvement with these therapies are encouraging.\u00a0 However, this enthusiasm must be tempered against a change in quality of life scores that is at the low end of clinical significance and the performance of multiple comparisons in the study analysis.<\/p>\n<p>Summarized by Steven M. Bradley and Supriya Shore<\/p>\n<ul>\n<li>Heldman AW, DiFede DL, Fishman JE, et al. Transendocardial mesenchymal stem cells and mononuclear bone marrow cells for ischemic cardiomyopathy: the TAC-HFT randomized trial. JAMA. 2014;311(1):62-73.<\/li>\n<\/ul>\n<p><!--TrendMD v2.4.8--><\/p>\n","protected":false},"excerpt":{"rendered":"<p>In this study, patients with chronic ischemic cardiomyopathy and EF &lt;50% on optimal medical therapy were randomized to autologous culture expanded mesenchymal cells (=22), autologous bone marrow mononuclear cells (n=22) or placebo vehicle (n=21) delivered by transendocardial stem cell injection (TESI). There were no serious adverse events among any patients undergoing a TESI procedure. Rates [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/heart\/2014\/04\/13\/mesenchymal-stem-cells-may-improve-quality-of-life-for-patients-with-ischemic-cardiomyopathy\/\">Read More&#8230;<\/a><\/p>\n","protected":false},"author":47,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[279,404],"tags":[2810,2871,2870],"class_list":["post-1575","post","type-post","status-publish","format-standard","hentry","category-general-cardiology","category-heart-failure","tag-cardiomyopathy","tag-ischaemic-cardiomyopathy","tag-mesenchymal-stem-cells"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Mesenchymal stem cells may improve quality of life for patients with ischemic cardiomyopathy - Heart<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/heart\/2014\/04\/13\/mesenchymal-stem-cells-may-improve-quality-of-life-for-patients-with-ischemic-cardiomyopathy\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mesenchymal stem cells may improve quality of life for patients with ischemic cardiomyopathy - Heart\" \/>\n<meta property=\"og:description\" content=\"In this study, patients with chronic ischemic cardiomyopathy and EF &lt;50% on optimal medical therapy were randomized to autologous culture expanded mesenchymal cells (=22), autologous bone marrow mononuclear cells (n=22) or placebo vehicle (n=21) delivered by transendocardial stem cell injection (TESI). There were no serious adverse events among any patients undergoing a TESI procedure. Rates [...]Read More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/heart\/2014\/04\/13\/mesenchymal-stem-cells-may-improve-quality-of-life-for-patients-with-ischemic-cardiomyopathy\/\" \/>\n<meta property=\"og:site_name\" content=\"Heart\" \/>\n<meta property=\"article:published_time\" content=\"2014-04-13T14:26:58+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2015-11-12T15:48:16+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/heart\\\/2014\\\/04\\\/13\\\/mesenchymal-stem-cells-may-improve-quality-of-life-for-patients-with-ischemic-cardiomyopathy\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/heart\\\/2014\\\/04\\\/13\\\/mesenchymal-stem-cells-may-improve-quality-of-life-for-patients-with-ischemic-cardiomyopathy\\\/\"},\"author\":{\"name\":\"\",\"@id\":\"\"},\"headline\":\"Mesenchymal stem cells may improve quality of life for patients with ischemic cardiomyopathy\",\"datePublished\":\"2014-04-13T14:26:58+00:00\",\"dateModified\":\"2015-11-12T15:48:16+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/heart\\\/2014\\\/04\\\/13\\\/mesenchymal-stem-cells-may-improve-quality-of-life-for-patients-with-ischemic-cardiomyopathy\\\/\"},\"wordCount\":257,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/heart\\\/#organization\"},\"keywords\":[\"cardiomyopathy\",\"ischaemic cardiomyopathy\",\"mesenchymal stem cells\"],\"articleSection\":[\"General cardiology\",\"Heart Failure\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/heart\\\/2014\\\/04\\\/13\\\/mesenchymal-stem-cells-may-improve-quality-of-life-for-patients-with-ischemic-cardiomyopathy\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/heart\\\/2014\\\/04\\\/13\\\/mesenchymal-stem-cells-may-improve-quality-of-life-for-patients-with-ischemic-cardiomyopathy\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/heart\\\/2014\\\/04\\\/13\\\/mesenchymal-stem-cells-may-improve-quality-of-life-for-patients-with-ischemic-cardiomyopathy\\\/\",\"name\":\"Mesenchymal stem cells may improve quality of life for patients with ischemic cardiomyopathy - 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