{"id":1751,"date":"2022-10-31T18:37:06","date_gmt":"2022-10-31T18:37:06","guid":{"rendered":"https:\/\/blogs.bmj.com\/bmjopen\/?p=1751"},"modified":"2022-10-31T18:37:06","modified_gmt":"2022-10-31T18:37:06","slug":"top-10-most-read-in-september-folic-acid-and-methotrexate-use-and-their-association-with-covid-19","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/bmjopen\/2022\/10\/31\/top-10-most-read-in-september-folic-acid-and-methotrexate-use-and-their-association-with-covid-19\/","title":{"rendered":"Top 10 most read in September: Folic acid and methotrexate use, and their association with COVID-19"},"content":{"rendered":"

\"\"<\/a><\/p>\n

While there has been some movement in our top 10 list this month, Zemedikun et al<\/em><\/a>. have retained the top spot. While COVID-19 still features in our list of most-read papers, we are starting to see a wider variety of topics beginning to make the cut.<\/span><\/p>\n

Our only new entry this month is by Topless et al<\/em>., who performed a case-control analysis<\/a> on data from the UK Biobank<\/span>. The authors aimed to determine whether having a methotrexate and\/or folic acid prescription was associated with differential risk for COVID-19 diagnosis or mortality. Using logistic regression statistical models, they found a 1.5-fold increased risk for COVID-19 diagnosis and 2.6-fold increased risk for COVID-19-related death among those who had been prescribed folic acid supplementation. They found that prescription of methotrexate was not associated with an increased risk of diagnosis of COVID-19 and they were unable to make an estimate for COVID-19-related death in the small sample of those who were only prescribed methotrexate. While the data come from a large population-based cohort, the authors acknowledge that their findings cannot be generalised outside of the middle-aged (>45 years of age), white European demographic that dominates the UK Biobank cohort. Furthermore, owing to the observational nature of the data, causality cannot be inferred from their findings.\u00a0<\/span><\/p>\n

Below is the full list of papers that were the most read in <\/span>BMJ Open<\/span><\/i> during September 2022.<\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n\n
*Most read figures are based on pdf downloads and full text views. Abstract views are excluded.<\/i><\/caption>\n
Rank* <\/b><\/td>\nAuthor(s) <\/b><\/td>\nTitle<\/b><\/td>\n<\/tr>\n
1<\/td>\nZemedikun <\/span>et al<\/i>.<\/td>\nBurden of chronic diseases associated with periodontal diseases: a retrospective cohort study using UK primary care data<\/span><\/a><\/td>\n<\/tr>\n
2<\/td>\nvan der Meulen et al<\/i>.<\/td>\nAssociation between use of systemic and inhaled glucocorticoids and changes in brain volume and white matter microstructure: a cross-sectional study using data from the UK Biobank<\/span><\/a><\/td>\n<\/tr>\n
3<\/td>\nBurns <\/span>et al<\/i>.<\/td>\nSystematic review and meta-analysis to examine intrapartum interventions, and maternal and neonatal outcomes following immersion in water during labour and waterbirth<\/span><\/a><\/td>\n<\/tr>\n
4<\/td>\nRisch <\/span>et al<\/i>.<\/td>\nInvestigation of the use of a sensor bracelet for the presymptomatic detection of changes in physiological parameters related to COVID-19: an interim analysis of a prospective cohort study (COVI-GAPP)<\/span><\/a><\/td>\n<\/tr>\n
5<\/td>\nOsanlou <\/span>et al<\/i>.<\/td>\nAdverse drug reactions, multimorbidity and polypharmacy: a prospective analysis of 1 month of medical admissions <\/span><\/a><\/td>\n<\/tr>\n
6<\/td>\nBergeron-Boucher <\/span>et al<\/i>.<\/td>\nProbability of males to outlive females: an international comparison from 1751 to 2020 <\/span><\/a><\/td>\n<\/tr>\n
7<\/td>\nWalach <\/span>et al<\/i>.<\/td>\nWhy do people consent to receiving SARS-CoV-2 vaccinations? A representative survey in Germany<\/span><\/a><\/td>\n<\/tr>\n
8<\/td>\nRehm <\/span>et al<\/i>.<\/td>\nDifferential impact of minimum unit pricing on alcohol consumption between Scottish men and women: controlled interrupted time series analysis <\/span><\/a><\/td>\n<\/tr>\n
9<\/td>\nTopless <\/span>et al<\/i>.<\/td>\nFolic acid and methotrexate use and their association with COVID-19 diagnosis and mortality: a case-control analysis from the UK Biobank<\/span><\/a><\/td>\n<\/tr>\n
10<\/td>\nFukuma <\/span>et al<\/i>.<\/td>\nImpact of the national health guidance intervention for obesity and cardiovascular risks on healthcare utilisation and healthcare spending in working-age Japanese cohort: regression discontinuity design<\/span><\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Like what you see? Follow this link<\/a> for all our most recent content.<\/span><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

While there has been some movement in our top 10 list this month, Zemedikun et al. have retained the top spot. While COVID-19 still features in our list of most-read papers, we are starting to see a wider variety of topics beginning to make the cut. Our only new entry this month is by Topless […]<\/p>\n

Read More…<\/a><\/p>\n","protected":false},"author":406,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[2470,2471],"tags":[],"class_list":["post-1751","post","type-post","status-publish","format-standard","hentry","category-content","category-highly-accessed"],"yoast_head":"\nTop 10 most read in September: Folic acid and methotrexate use, and their association with COVID-19 - BMJ Open<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/bmjopen\/2022\/10\/31\/top-10-most-read-in-september-folic-acid-and-methotrexate-use-and-their-association-with-covid-19\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Top 10 most read in September: Folic acid and methotrexate use, and their association with COVID-19 - BMJ Open\" \/>\n<meta property=\"og:description\" content=\"While there has been some movement in our top 10 list this month, Zemedikun et al. have retained the top spot. 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