Evidence Watch: Can clinical decision support tools optimise anticoagulant therapy?

  High baseline adherence rates for guidelines recommendations means that a clinical decision support system makes only a small difference in clinical outcomes for atrial fibrillation patients.   Carl Heneghan The evidence for the association of atrial fibrillation with stroke risk is clear. However, there remain persistent levels of under treatment in clinical practice. Clinical decision […]

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Weight loss drugs effects on cardiometabolic profile remains unproven.

  Approved weight-loss medications have only modest effects on cardiovascular risk. Igho Onakpoya One rationale for the development and marketing of weight loss drugs is that their use will improve cardiac risk factors. In a recent systematic review and network meta-analysis [1]  of 28 randomised controlled trials (29,018 participants), the authors concluded that the effects […]

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Evidence Watch: should ‘rooming in’ be the norm?

  Evidence suggests rooming-in should be the norm in hospitals but what factors will limit uptake  Carl Heneghan Here’s what we selected this week: Daily vs intermittent antituberculosis therapy for pulmonary tuberculosis in patients with HIV a randomized clinical trial. JAMA Internal Medicine, 178(4), 485–493. Bottom line:  HIV-positive patients with pulmonary TB receiving antiretroviral therapy, do […]

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Frailty’s impact on mortality

  A systematic review concludes that frailty is a predictor of mortality, but does it aid decision making in practice? Carl Heneghan A recent systematic review included 18 cohort studies including 65,048 participants. The results suggested that higher Frailty index was significantly associated with higher mortality risk. For every 0.01 increase in the index the […]

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Evidence Watch: Carl Heneghan’s selection of evidence that impacts on practice

  This week’s Evidence Watch highlights the risk of pre-eclampsia with metformin, the role of repeated influenza vaccination, de-prescribing medications and assessing harms in the elderly at the time of elective surgery. Carl Heneghan, Editor in Chief A meta-analysis evaluating the risk of pre-eclampsia in women taking metformin before, or during pregnancy found that there […]

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EBM library: Systematic reviews in policymaking – part 2

  The EBM library signposts some essential reading for the practice of Evidence-Based Medicine. In this part of the library, we highlight papers that reflect the role of systematic reviews in policymaking. Kamal Mahtani In part 1 of this series two papers highlighted why systematic reviews are important in policymaking, and some challenges this may bring. In […]

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BMJ Evidence-Based Medicine Strategy

  BMJ EBM publishes original evidence-based research, insights and opinions on what matters for health care. Carl Heneghan, Editor in Chief, BMJ EBM The BMJ Evidence-Based Medicine strategy focuses on the tools, methods, and concepts that are basic and central to practising evidence-based medicine.     How we deliver relevant, trustworthy and impactful evidence: By Disseminating relevant research: saving […]

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