EBM Roundup – Devices and Facebook vaccines

  In the second of our EBM round-ups, Carl Heneghan, Helen Macdonald and Duncan Jarvies are joined by Deborah Cohen, investigative journalist and scourge of device manufacturers. We’re giving our verdict on the sensitivity and specificity of ketone testing for hyperemesis, and the advice to drinking more water to prevent recurrent UTIs in women. Deb […]

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Carl Heneghan: Why EU Medical Device Regulations are a smokescreen

  I’ve taken a look at the new EU medical device regulation including the clinical evidence required, the postmarketing data needed and the proposed device database and how it might be interpreted. Carl Heneghan The International Consortium of Investigative Journalist (ICIJ) has published the “Implant Files.” Their global investigation, which I’ve been a part of,  […]

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Harms in Healthcare: Primodos, Vaginal Mesh and Sodium Valproate

The UK Government is holding a review after patient-led campaigns on 3 NHS treatments: the hormone pregnancy test Primodos used up until 1978; the anti-epileptic drug sodium valproate and its use in pregnancy and the use of vaginal mesh. Carl Heneghan Next week I’ve been asked to present evidence to the Independent Medicines & Medical […]

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Clinical Trials transparency is failing – here’s why

  ‘the current system is failing, and awareness isn’t  ‘variable’, it is wholly inappropriate and unethical.’ Carl Heneghan The UK’s House of Commons Science and Technology Committee released its report on clinical trials transparency last week and it makes for a sorry read. Clinical trials transparency means ensuring clinical trials are recorded in a publicly-accessible […]

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Editors’ Review of BMJ EBM’s Analysis of Cochrane’s HPV Systematic Review 

     On 27 July 2018, BMJ EBM published an analysis [1] that outlined problems with Cochrane’s systematic review of human papillomavirus (HPV) vaccine, which we shall refer to as the Cochrane HPV Review, published in May 2018; this included missing eligible trials, reporting bias, and biased trial designs and conflicts of interest. [2,3] In […]

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TVT: seventeen year follow up and the shrinking denominator effect

  The shrinking denominator enhances the effect size and misleads the reader into thinking the effect is better than it actually is. Carl Heneghan I am at the Ideal Conference, at a workshop talking about clinical trial reporting and recent surgical scandals.  I chose the 17 years follow-up of the Tension-free Vaginal Tape – often quoted – […]

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Do Calcium and Vitamin D supplements cause cancer?

  In a recent trial calcium and vitamin D treatment elevated the risk of precancerous polyps nearly fourfold – but does this result matter?  Carl Heneghan If you weren’t observing carefully, you likely missed this study, I did. A recent randomised trial participants with one or more adenomas received daily calcium, vitamin D3, both or […]

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