Can an antibiotic make you pregnant?

Blog entry written on: Analysis of reports of unintended pregnancies associated with the combined use of non-enzyme-inducing antibiotics and hormonal contraceptives (bmjebm-2020-111363) Authors: Jeffrey K Aronson & Robin E Ferner The British National Formulary (BNF) currently advises women to continue with their usual oral contraception when they start an antibiotic (except for enzyme inducers, e.g. […]

Read More…

Honey for coughs and colds: not too shab-bee

Blog entry written on: Effectiveness of honey for symptomatic relief in upper respiratory tract infections: a systematic review and meta-analysis (bmjebm-2020-111336) Author: Hibatullah Abuelgasim Honey is a folklore favourite when it comes to cough and cold remedies. Everyone who has ever had a cold knows how annoying the symptoms can be. Unfortunately, there’s not much […]

Read More…

The Dangers of Selective Analysis: Has stroke treatment been misguided for a decade?

  Alteplase is widely recommended for treatment of stroke occurring within 3-4.5 hours. Brian Alper discusses their recent publication that reanalysed the Third European Cooperative Acute Stroke Study (ECASS III) trial through adjustment for baseline imbalances. Blog entry written on: Thrombolysis with alteplase 3–4.5 hours after acute ischaemic stroke: trial reanalysis adjusted for baseline imbalances (bmjebm-2020-111386) […]

Read More…

How are you managing hip fracture patients on DOACs?

In an attempt to end the dilemma surrounding the management of hip fracture patients on direct oral anticoagulants, Sheweidin Aziz, Krishan Almeida, and Grahame Taylor share the highlights of their recent publication. Blog entry written on: How should we manage hip fracture patients on direct oral anticoagulants? (bmjebm-2019-111317) Authors: Sheweidin Aziz, Krishnan Almeida, and Grahame […]

Read More…

Shining a spotlight on the policies of pain journals

Journals are key stakeholders in the quest for greater transparency and reproducibility of research. Georgia Richards, Aidan Cashin, Matthew Bagg, Elaine Toomey, James McAuley and Hopin Lee discuss their recent publication that evaluates the policies and standards of pain journals. Blog entry written on: Limited engagement with transparent and open science standards in the policies […]

Read More…

What a Mesh

  The release of NICE guidelines allows MESH to be used in the NHS  once again; the guidance, however, has proved controversial: MPs and campaigners have warned NICE guidance neglects the serious risks associated with the use of mesh in surgery. They also fear the evidence is untrustworthy, biased and too low quality to inform […]

Read More…

BMJ EBM Verdict Tracker

  The EBM Verdict tracker is updated monthly to select the research evidence that can matter to clinical practice: EBM Verdict articles are published in BMJ EBM. EBM Verdict Evidence that helps you come to a definitive conclusion and can be implemented into clinical practice. Introducing the EBM Verdict: research evidence relevant to clinical practice […]

Read More…

Assessing bias in studies of harms: a case study of Primodos and congenital malformations

  In a recent systematic review, we assessed the use of Primodos, an oral hormone pregnancy test (HPT) marketed between 1958 and 1978, and the associated risk of congenital malformations. This post discusses the assessment of quality in assessing associations of harms.  Carl Heneghan We found oral HPTs in pregnancy was associated with an increased […]

Read More…

Gender-affirming hormone in children and adolescents

  Gender dysphoria occurs when a person experiences discomfort or distress because of a mismatch between their biological sex and gender identity.  Gender dysphoria can arise in childhood and adolescent which raises many questions about how best to handle the condition. This post sets out some of  the current evidence for gender-affirming hormones in adolescents […]

Read More…

Pregabalin in neuropathic pain

Pregabalin has some beneficial effects in the management of neuropathic pain. However, there is an increased risk of adverse events and discontinuation because of adverse events. Igho Onakpoya In our recent systematic review [1], we searched for evidence from human trials that compared pregabalin with dummies in patients with neuropathic pain. We included studies of neuropathic […]

Read More…