BMJ EBM Verdict Tracker

  The EBM Verdict tracker is updated monthly to select the research evidence that can matter to clinical practice: EBM Verdict articles are published in BMJ EBM. EBM Verdict Evidence that helps you come to a definitive conclusion and can be implemented into clinical practice. Introducing the EBM Verdict: research evidence relevant to clinical practice […]

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Assessing bias in studies of harms: a case study of Primodos and congenital malformations

  In a recent systematic review, we assessed the use of Primodos, an oral hormone pregnancy test (HPT) marketed between 1958 and 1978, and the associated risk of congenital malformations. This post discusses the assessment of quality in assessing associations of harms.  Carl Heneghan We found oral HPTs in pregnancy was associated with an increased […]

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Gender-affirming hormone in children and adolescents

  Gender dysphoria occurs when a person experiences discomfort or distress because of a mismatch between their biological sex and gender identity.  Gender dysphoria can arise in childhood and adolescent which raises many questions about how best to handle the condition. This post sets out some of  the current evidence for gender-affirming hormones in adolescents […]

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Pregabalin in neuropathic pain

Pregabalin has some beneficial effects in the management of neuropathic pain. However, there is an increased risk of adverse events and discontinuation because of adverse events. Igho Onakpoya In our recent systematic review [1], we searched for evidence from human trials that compared pregabalin with dummies in patients with neuropathic pain. We included studies of neuropathic […]

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Updated EU Medical Device Regulations: do they make a difference?

  I’ve taken a look at the new EU medical device regulation including the clinical evidence required, the postmarketing data needed and the proposed device database and how it might be interpreted. Carl Heneghan The International Consortium of Investigative Journalist (ICIJ) has published the “Implant Files.” Their global investigation, which I’ve been a part of,  […]

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Harms in Healthcare: Primodos, Vaginal Mesh and Sodium Valproate

The UK Government is holding a review after patient-led campaigns on 3 NHS treatments: the hormone pregnancy test Primodos used up until 1978; the anti-epileptic drug sodium valproate and its use in pregnancy and the use of vaginal mesh. Carl Heneghan Next week I’ve been asked to present evidence to the Independent Medicines & Medical […]

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Response to Cochrane editors: Jørgensen, Gøtzsche and Jefferson

  Jørgensen, 1Gøtzsche 1 and Jefferson 1  consider their analysis was appropriate and that the Cochrane editors substantially ignored several of their criticisms. 1Nordic Cochrane Centre, Rigshospitalet 7811, Tagensvej 21, 2100 Copenhagen, Denmark. Originally posted at: The Cochrane HPV vaccine review was incomplete and ignored important evidence of bias: Response to the Cochrane editors. at BMJ EBM on 17 September […]

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