Pregabalin in neuropathic pain: Short-term benefits – increased harms

Pregabalin has some beneficial effects in the management of neuropathic pain. However, there is an increased risk of adverse events and discontinuation because of adverse events. Igho Onakpoya In our recent systematic review [1], we searched for evidence from human trials that compared pregabalin with dummies in patients with neuropathic pain. We included studies of neuropathic […]

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Updated EU Medical Device Regulations: do they make a difference?

  I’ve taken a look at the new EU medical device regulation including the clinical evidence required, the postmarketing data needed and the proposed device database and how it might be interpreted. Carl Heneghan The International Consortium of Investigative Journalist (ICIJ) has published the “Implant Files.” Their global investigation, which I’ve been a part of,  […]

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Harms in Healthcare: Primodos, Vaginal Mesh and Sodium Valproate

The UK Government is holding a review after patient-led campaigns on 3 NHS treatments: the hormone pregnancy test Primodos used up until 1978; the anti-epileptic drug sodium valproate and its use in pregnancy and the use of vaginal mesh. Carl Heneghan Next week I’ve been asked to present evidence to the Independent Medicines & Medical […]

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Response to Cochrane editors: Jørgensen, Gøtzsche and Jefferson

  Jørgensen, 1Gøtzsche 1 and Jefferson 1  consider their analysis was appropriate and that the Cochrane editors substantially ignored several of their criticisms. 1Nordic Cochrane Centre, Rigshospitalet 7811, Tagensvej 21, 2100 Copenhagen, Denmark. Originally posted at: The Cochrane HPV vaccine review was incomplete and ignored important evidence of bias: Response to the Cochrane editors. at BMJ EBM on 17 September […]

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Cochrane – A sinking ship?

  By Maryanne Demasi, PhD A scandal has erupted within the Cochrane Collaboration, the world’s most  prestigious scientific organisation devoted to independent reviews of health care interventions.  One of its highest profile board members has been sacked, resulting in four other board members staging a mass exodus. They are protesting, what they describe as, the […]

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Bronchial Thermoplasty – evidence does not back up NICE approval

  We’ve been here before with devices, the studies are small, biased, there is lots of uncertainty about who, if anyone, benefits from this treatment and the adverse events including admissions are higher. Carl Heneghan Bronchial Thermoplasty is all over the news today: The BBC reports that the New asthma treatment is set for wider […]

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