Diagnosing childhood coeliac disease without biopsy

  Can a diagnosis of coeliac disease in children be made without doing a biopsy? Annette Pluddemann Current NICE guidelines recommend that in children referred with a positive serological test result, further investigations to rule in or rule out coeliac disease may use combinations of IgA EMA serological testing, HLA genetic testing and endoscopic biopsy. […]

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Weight loss drugs effects on CVD remains unproven.

  Approved weight-loss medications have only modest effects on cardiovascular risk. Igho Onakpoya One rationale for the development and marketing of weight loss drugs is that their use will improve cardiac risk factors. In a recent systematic review and network meta-analysis [1]  of 28 randomised controlled trials (29,018 participants), the authors concluded that the effects […]

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Prostate cancer now kills more people than breast cancer: cause for alarm?

  ‘As epidemiologists, we are not alarmed by the apparent ‘increase’ in deaths from prostate cancer,’ here’s why Jason Oke For the first time in the UK, the number of deaths from prostate cancer has exceeded the numbers of deaths from breast cancer. According to figures from the UK’s Office for National Statistics (ONS), more […]

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Evidence Watch: uncertainties with the evidence for influenza vaccination

  This week’s Evidence Watch highlights serious uncertainties with the current evidence-base for influenza vaccination Carl Heneghan, Editor in Chief  A systematic review of vaccines in the elderly [1] highlights the difference vaccination makes in a single season (lowers risk of influenza from 6% to 2.4%); but adds caution, in that we have very little […]

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Why BRCA screening will harm (some) women

  ‘blindly pursuing early detection risks subjecting a third of diagnosed women to unnecessary harm.’ Jason Oke According to research led by the Barts Cancer Institute at Queen Mary University London, screening all British women over 30 years of age could result in 17,000 fewer ovarian and 64,000 breast cancers over a lifetime. Not only […]

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A Word About Evidence: 3. Manifesto

  A manifesto for Evidence-Based Medicine (EBM) was published in the BMJ earlier this year and presented at Evidence Live. Jeff Aronson has been thinking again about the word manifesto. The Indo-European root MAN meant a hand. The Latin word was manus, from which we get words such as maintain, manacle, manage, manège, manicure, manipulate, […]

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