Response to Cochrane editors: Jørgensen, Gøtzsche and Jefferson

  Jørgensen, 1Gøtzsche 1 and Jefferson 1  consider their analysis was appropriate and that the Cochrane editors substantially ignored several of their criticisms. 1Nordic Cochrane Centre, Rigshospitalet 7811, Tagensvej 21, 2100 Copenhagen, Denmark. Originally posted at: The Cochrane HPV vaccine review was incomplete and ignored important evidence of bias: Response to the Cochrane editors. at BMJ EBM on 17 September […]

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Cochrane – A sinking ship?

  By Maryanne Demasi, PhD A scandal has erupted within the Cochrane Collaboration, the world’s most  prestigious scientific organisation devoted to independent reviews of health care interventions.  One of its highest profile board members has been sacked, resulting in four other board members staging a mass exodus. They are protesting, what they describe as, the […]

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TVT: seventeen year follow up and the shrinking denominator effect

  The shrinking denominator enhances the effect size and misleads the reader into thinking the effect is better than it actually is. Carl Heneghan I am at the Ideal Conference, at a workshop talking about clinical trial reporting and recent surgical scandals.  I chose the 17 years follow-up of the Tension-free Vaginal Tape – often quoted – […]

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Bronchial Thermoplasty – evidence does not back up NICE approval

  We’ve been here before with devices, the studies are small, biased, there is lots of uncertainty about who, if anyone, benefits from this treatment and the adverse events including admissions are higher. Carl Heneghan Bronchial Thermoplasty is all over the news today: The BBC reports that the New asthma treatment is set for wider […]

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Medicine: more precise, more effective, more overdiagnosis

  I’m at the 6th preventing overdiagnosis conference chairing a session on Overdiagnosis 2.0 (Technology) by  Henrik Vogt, Claus Ekstrøm & Johnny Kung.  So I thought I’d share some insights. Carl Heneghan at Preventing Overdiagnosis Henrik Vogt from the GP research unit at Trondheim talked about the impact of new technology ‘that is heavily geared to […]

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Do Calcium and Vitamin D supplements cause cancer?

  In a recent trial calcium and vitamin D treatment elevated the risk of precancerous polyps nearly fourfold – but does this result matter?  Carl Heneghan If you weren’t observing carefully, you likely missed this study, I did. A recent randomised trial participants with one or more adenomas received daily calcium, vitamin D3, both or […]

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David Sackett’s four worries about observational evidence

  EBM students, if you haven’t already seen this paper then it’s a must-read: Why Did the Randomized Clinical Trial Become the Primary Focus of My Career?  Carl Heneghan The late David Sackett, the first Director of CEBM, undertook, wrote about and researched the methods of randomized controlled trials for most of his career. Why? […]

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NHS Health Check appears neither equitable nor cost-effective

NHS health checks may be missing the point when it comes to offering the optimal interventions and preventing cardiovascular disease. Carl Heneghan Since 2009 the NHS Health Check programme in England has added considerably to GP workload and has proved to be controversial given the uncertainty about whether it adds value. A Cochrane review found […]

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