What a Mesh

  The release of NICE guidelines allows MESH to be used in the NHS  once again; the guidance, however, has proved controversial: MPs and campaigners have warned NICE guidance neglects the serious risks associated with the use of mesh in surgery. They also fear the evidence is untrustworthy, biased and too low quality to inform […]

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BMJ EBM Verdict Tracker

  The EBM Verdict tracker is updated monthly to select the research evidence that can matter to clinical practice: EBM Verdict articles are published in BMJ EBM. EBM Verdict Evidence that helps you come to a definitive conclusion and can be implemented into clinical practice. Introducing the EBM Verdict: research evidence relevant to clinical practice […]

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Assessing bias in studies of harms: a case study of Primodos and congenital malformations

  In a recent systematic review, we assessed the use of Primodos, an oral hormone pregnancy test (HPT) marketed between 1958 and 1978, and the associated risk of congenital malformations. This post discusses the assessment of quality in assessing associations of harms.  Carl Heneghan We found oral HPTs in pregnancy was associated with an increased […]

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Gender-affirming hormone in children and adolescents

  Gender dysphoria occurs when a person experiences discomfort or distress because of a mismatch between their biological sex and gender identity.  Gender dysphoria can arise in childhood and adolescent which raises many questions about how best to handle the condition. This post sets out some of  the current evidence for gender-affirming hormones in adolescents […]

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Pregabalin in neuropathic pain

Pregabalin has some beneficial effects in the management of neuropathic pain. However, there is an increased risk of adverse events and discontinuation because of adverse events. Igho Onakpoya In our recent systematic review [1], we searched for evidence from human trials that compared pregabalin with dummies in patients with neuropathic pain. We included studies of neuropathic […]

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