{"id":5228,"date":"2010-10-22T10:26:12","date_gmt":"2010-10-22T09:26:12","guid":{"rendered":"https:\/\/blogs.bmj.com\/bmj\/?p=5228"},"modified":"2010-10-22T10:47:30","modified_gmt":"2010-10-22T09:47:30","slug":"research-highlights-22-october-2010","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/bmj\/2010\/10\/22\/research-highlights-22-october-2010\/","title":{"rendered":"Research highlights &#8211; 22 October 2010"},"content":{"rendered":"<p><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.bmj.com\/site\/blog\/icons\/research-methods-and-reporting.jpg\" alt=\"Research questions\" width=\"160\" height=\"110\" align=\"left\" \/> &#8220;Research highlights\u201d is a weekly round-up of research papers appearing in the print <em>BMJ<\/em>. We start off with this week\u2019s research questions, before providing more detail on some individual research papers and accompanying articles.<!--more--><\/p>\n<ul>\n<li><a href=\"http:\/\/www.bmj.com\/content\/341\/bmj.c5222.full\">Compared with selective serotonin reuptake inhibitors, how effective are tricyclic antidepressants in treating headaches and what are the adverse effects?<\/a><\/li>\n<li><a href=\"http:\/\/www.bmj.com\/content\/341\/bmj.c5293.full\">What interventions are effective in promoting cycling, and are there associated benefits for activity or body shape?<\/a><\/li>\n<li><a href=\"http:\/\/www.bmj.com\/content\/341\/bmj.c4564.full\">What were the early lessons from the England-wide implementation of detailed electronic health records?<\/a><\/li>\n<li><a href=\"http:\/\/www.bmj.com\/content\/341\/bmj.c5367.full\">How is ethnic mix in a neighbourhood associated with the prevalence of common mental disorders?<\/a><\/li>\n<\/ul>\n<p><a href=\"http:\/\/www.bmj.com\/content\/341\/bmj.c5367.full\">Neighbourhood ethnic mix and mental health<\/a><br \/>\nLast week the UK Equality and Human Rights Commission (which the government hasn\u2019t thrown on to the bonfire of the quangos but which, it reckons, needs \u201csubstantial reform\u201d) <a href=\"http:\/\/bit.ly\/9URMuG\">reported that<\/a> \u201cPakistani and Bangladeshi groups are more likely to experience poor mental health, more likely to report a disability or limiting long term illness, and more likely to find it hard to access and communicate with their GPs than other groups\u2026It is unclear how far these worse than average outcomes are related to Pakistani, Bangladeshi, and Muslim people\u2019s relatively poor socioeconomic position.\u201d<\/p>\n<p>Jayati Das-Munshi and colleagues provide some of that missing detail in their multi-level logistic regression analysis of the ethnic minorities psychiatric illness rates in the community (EMPIRIC) survey, a cross sectional, nationally representative survey of adults in England in 2000. They looked at self reported ethnicity in \u201cmiddle layer super output areas,\u201d survey speak for geographical areas with a mean population of about 7200 people. For each 10 percentage point rise in \u201cown group ethnic density\u201d in these areas\u2014which, for an individual, is the percentage of people of the same ethnic group living in the same area\u2014there was a decreased risk of common mental disorders for all local people from ethnic minorities (odds ratio 0.94, 95% CI 0.89 to 0.99) after adjustment for age, social class, educational level, sex, marital status, and level of deprivation in the area. The reduced risk was most striking for Bangladeshi and Irish groups. Living in areas of higher own group density was also associated with fewer reported experiences of discrimination or racism and with improved social support and improved social networks for some groups.<\/p>\n<p><a href=\"http:\/\/www.bmj.com\/content\/341\/bmj.c5252.full\">Editorialist Helen Lester <\/a>says we\u2019ve known for nearly a century that living in areas with people of the same ethnicity may be protective for mental health. The strengths of this study, says Professor Lester, include its nationally representative data and the ways it highlights \u201cthe messy complexity of the relationship between ethnic density and mental health.\u201d The authors agree that \u201cThere were no neat conclusions from our analyses [and] we were not able to definitively unpack the meaning of ethnic density.&#8221; For more discussion of this intriguing work, listen to our podcast interview with Dr Das-Munshi at <a href=\"http:\/\/www.bmj.com\/podcasts\">www.bmj.com\/podcasts<\/a>.<\/p>\n<p><a href=\"http:\/\/www.bmj.com\/content\/341\/bmj.c5293.full\">Interventions to promote cycling<\/a><br \/>\nThe Mayor of London\u2019s cycle hire scheme, which provides (almost) free bicycles for 30 minute journeys in the city, was launched amid much fanfare in July this year. However, mayor Boris Johnson might be dismayed to read Lin Yang and colleagues\u2019 systematic review of interventions to promote cycling in seven countries, including the United Kingdom and the United States.<\/p>\n<p>Of the 25 published and unpublished studies assessed, those that evaluated interventions to promote cycling at population level reported net increases of only 3.4 percentage points in the population prevalence of cycling or the proportion of trips made by bicycle. Whether interventions resulted in an increase in overall physical activity or changes in anthropometric measures was unclear.<\/p>\n<p><a href=\"http:\/\/student.bmj.com\/student\/view-article.html?id=sbmj.c5621\">Student BMJ has also covered the topic<\/a> of interventions to promote cycling, looking specifically at the London bike hire scheme. Authors Harry Rutter and Nick Cavill question whether the public health benefits of the scheme outweigh the associated risks of injury and long term exposure to traffic related air pollution.<\/p>\n<p>Nevertheless, <a href=\"http:\/\/www.bmj.com\/content\/341\/bmj.c5405.full\">editorialists Nanette Mutrie and Fiona Crawford<\/a> argue that an increase in everyday cycling could generate a considerable public health gain and that \u201cbetter measurement of the impacts of interventions on levels of cycling and physical activity is necessary\u2026to strengthen the case that promoting cycling represents extremely good value for money for both individual and public health.\u201d<\/p>\n<p>Research online: For this and other new research articles see <a href=\"http:\/\/www.bmj.com\/research\">www.bmj.com\/research<\/a><\/p>\n<p><a href=\"http:\/\/www.bmj.com\/content\/341\/bmj.c4737\">Antidepressants and publication bias<\/a><br \/>\nLast week we published a meta-analysis reporting that the antidepressant reboxetine is ineffective and potentially harmful, and that the published literature on the drug is skewed by publication bias. The research has received considerable coverage in the press and online, much of it focusing on the \u201cserious obstacles\u201d the authors encountered when they tried to get unpublished clinical trial information from the drug company Pfizer, which sells the drug in Europe (BMJ 2010;341:c5641,<a href=\"http:\/\/www.bmj.com\/content\/341\/bmj.c5641.full\"> doi:10.1136\/bmj.c5641<\/a>).<\/p>\n<p>\u201cScientists accuse Pfizer of holding back studies which reveal drug sold as Edronax to be ineffective and potentially harmful,\u201d <a href=\"http:\/\/bit.ly\/dbJ1ll\">wrote the Guardian<\/a>, while the <a href=\"http:\/\/bbc.in\/abCvsY\">BBC stated that<\/a> the public had been \u201c\u2018misled\u2019 by drug trial claims.\u201d<\/p>\n<p>Perhaps surprisingly, given that reboxetine has not been licensed in the United States, the research also got plenty of coverage across the pond. American writer Scott Hensley describes reboxetine as \u201cthe crummiest antidepressant you\u2019ve never heard of\u201d <a href=\"http:\/\/n.pr\/axvkSP\">in his health blog<\/a> on the National Public Radio website, whereas <a href=\"http:\/\/bit.ly\/bNfZt0\">Genetic Engineering and Biotechnology News<\/a> asks \u201cDid sneaky publication tactics help Pfizer\u2019s reboxetine slip through to market?&#8221;<\/p>\n<p>The responses to this research certainly indicate how concerned people are about pharmaceutical companies sitting on data about their drugs, but what can be done? The BMJ has taken the first steps to uncovering the extent of the problem and will devote a special theme issue to the topic in late 2011.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&#8220;Research highlights\u201d is a weekly round-up of research papers appearing in the print BMJ. We start off with this week\u2019s research questions, before providing more detail on some individual research [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/bmj\/2010\/10\/22\/research-highlights-22-october-2010\/\">More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-5228","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Research highlights - 22 October 2010 - The BMJ<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/bmj\/2010\/10\/22\/research-highlights-22-october-2010\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research highlights - 22 October 2010 - The BMJ\" \/>\n<meta property=\"og:description\" content=\"&#8220;Research highlights\u201d is a weekly round-up of research papers appearing in the print BMJ. 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