{"id":43294,"date":"2018-10-19T15:28:17","date_gmt":"2018-10-19T14:28:17","guid":{"rendered":"https:\/\/blogs.bmj.com\/bmj\/?p=43294"},"modified":"2018-10-26T16:14:35","modified_gmt":"2018-10-26T15:14:35","slug":"jeffrey-aronson-when-i-use-a-word-the-medicines-act-1968-data-sheets-and-summaries-of-product-characteristics","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/bmj\/2018\/10\/19\/jeffrey-aronson-when-i-use-a-word-the-medicines-act-1968-data-sheets-and-summaries-of-product-characteristics\/","title":{"rendered":"Jeffrey Aronson: When I use a word . . . The Medicines Act 1968, Data Sheets, and Summaries of Product Characteristics"},"content":{"rendered":"

\"jeffrey_aronson\"<\/a>Last week<\/span><\/a>, during my exploration of the <\/span>Medicines Act 1968<\/span><\/a>, I discussed its provisions in relation to the promotion of sales of medicinal products, and the idea of a data sheet that the Act introduced.<\/span><\/p>\n

The Latin verb to give is d\u0101r\u0113 (in which both vowels are pronounced separately, as marked). The verb reduplicates in the perfect tense as dedi, mimicking the repetition of a past action; giving is meant to be repetitive. The past participle of the verb is datum, meaning \u201cgiven\u201d, which then becomes a noun of neuter gender, meaning something that is given or is due to be given\u2014a present, a debit, or a debt. The plural of \u201cdatum\u201d is \u201cdata\u201d. But whether you treat \u201cdata\u201d in English as singular or plural is debated. Computer scientists tend to prefer the singular, but a majority of them and most others still use the plural.<\/span><\/p>\n

One problem in considering whether \u201cdata\u201d is singular or plural arises partly from the fact that the singular form, datum, is generally used only in a technical sense to mean a baseline, benchmark, or reference point (as in datum level, datum line, datum mark, datum point). Although it can be used to mean a single piece of information, such usage is rare. On the other hand, \u201cdata\u201d is used to mean either a whole lot of pieces of information (technically the plural of a count noun\u2014one datum, many data) or a collection of such pieces (technically a non-count or mass noun\u2014much data).<\/span><\/p>\n

You can test whether you want to use the plural or singular by qualifying \u201cdata\u201d with words such as \u201call\u201d (\u201call the data are\u201d), \u201cmany\u201d (there are many data), and \u201cmuch\u201d (\u201cmuch data supports\u201d). Doing that will help you to decide whether you are thinking of the individual pieces of information or the whole collection or a discrete part of it. I have discussed all this in more detail <\/span>elsewhere<\/span><\/a>. Surprisingly, since so many people seem to say \u201cdata is\u201d or \u201cthis data\u201d these days, when I surveyed the instances of singular and plural usages in Pubmed I <\/span>found<\/span><\/a> that more than 80% of all authors used the plural form (Figure 1). There was however, a difference across scientific specialties, with pharmacologists, pathologists, biochemists, clinicians, and veterinarians all using the plural more than 90% of the time, contrasting with epidemiologists (89%), statisticians (78%), mathematicians (71%), and computer scientists (67%).<\/span><\/p>\n

\"\"<\/p>\n

Figure 1.<\/b> The frequencies of the plural terms \u201cthese data\u201d and \u201cdata are\u201d as textwords in Pubmed, compared with the singular terms \u201cthis data\u201d and \u201cdata is\u201d, expressed as the percentages of all plural plus singular instances 1960\u20132017; the plural forms are still used in over 80% of cases overall<\/span><\/p>\n

So is \u201cdata\u201d singular or plural? Etymology, grammar, and usage all say plural, a triple whammy, although there may be some instances when the singular form can be used. My own preference is to regard \u201cdata\u201d as plural and to use \u201cinformation\u201d as the singular. However, when \u201cdata\u201d (plural) is used attributively, as in \u201cdatabase\u201d, \u201cdatabank\u201d, and \u201cdata sheet\u201d, the compound form is obviously singular.<\/span><\/p>\n

A data sheet was defined in section 96(6) of the Medicines Act 1968 as \u201ca document relating to medicinal products of a particular description, which is prepared by or on behalf of the holder of a product licence which is applicable to medicinal products of that description and which (a) complies with such requirements as to dimensions and form, as to the particulars to be contained in it, and as to the manner (whether in respect of type, size, colour or disposition of lettering or otherwise) in which any such particulars are to be so contained, as may be prescribed for the purposes of this subsection, and (b) does not contain any information relating to medicinal products of that description except the particulars so prescribed.\u201d A complicated description of a relatively simple document.<\/span><\/p>\n

The <\/span>Medicines (Data Sheet) Regulations<\/span><\/a> 1972 defined the particulars to be described in three schedules. Schedule 1 described the type of paper and print required; white A5 paper with black printing, typed in not less than 6 Didot Univers font or equivalent, with headings and subheadings in no more than 18 point bold.<\/span><\/p>\n

Schedules 2 and 3 described the particulars required for medicinal products for human and animal use respectively: name of the product, pharmaceutical formulation (with ingredients), uses (actions and authorized indications), dosage and administration, contraindications, warnings, precautions, and action to be taken after overdosage, pharmaceutical precautions (e.g. storage conditions), legal category, package quantities, product licence numbers, and the names and addresses of those responsible for sale and supply.<\/span><\/p>\n

In 1996, Data Sheets began to be replaced by Summaries of Product Characteristics (SmPCs) and were completely replaced by them by 2002. The European Union\u2019s Directive <\/span>2004\/27\/EC<\/span><\/a> lists the information about a medicinal product that EU law requires in the Summary of Product Characteristics (Figure 2).<\/span><\/p>\n

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Figure 2.<\/b> The headings under which information about a medicinal product must be given in the Summary of Product Characteristics by EU law (<\/span>from<\/span><\/a> Aronson & Ferner. Br J Clin Pharmacol 2017; 83(12): 2615-25)<\/span><\/p>\n

The regulations also allowed for the publication of a compendium of such data sheets, and the first such compendium was published in December 1973. Those compendia were later replaced by compendia of the SmPCs, and those are now available <\/span>online<\/span><\/a> as the electronic Medicine Compendium (eMC). What a compendium actually is, or should be, will have to wait for another day.<\/span><\/p>\n

Jeffrey Aronson<\/strong>\u00a0is a clinical pharmacologist, working in the Centre for Evidence Based Medicine in Oxford’s Nuffield Department of Primary Care Health Sciences. He is also president emeritus of the British Pharmacological Society.<\/em><\/p>\n

Competing interests:<\/strong>\u00a0None declared.<\/p>\n","protected":false},"excerpt":{"rendered":"

Last week, during my exploration of the Medicines Act 1968, I discussed its provisions in relation to the promotion of sales of medicinal products, and the idea of a data […]<\/p>\n

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