{"id":43018,"date":"2018-09-12T18:00:09","date_gmt":"2018-09-12T17:00:09","guid":{"rendered":"https:\/\/blogs.bmj.com\/bmj\/?p=43018"},"modified":"2018-09-13T08:42:34","modified_gmt":"2018-09-13T07:42:34","slug":"fast-tracked-pharmacoepidemiology-in-drug-safety-issues","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/bmj\/2018\/09\/12\/fast-tracked-pharmacoepidemiology-in-drug-safety-issues\/","title":{"rendered":"Fast-tracked pharmacoepidemiology in drug safety issues"},"content":{"rendered":"<p><span style=\"font-weight: 400\">This July, it was discovered that <\/span><a href=\"https:\/\/www.fda.gov\/newsevents\/newsroom\/pressannouncements\/ucm613532.htm\"><span style=\"font-weight: 400\">some valsartan products<\/span><\/a><span style=\"font-weight: 400\"> (used for treatment of hypertension and heart failure) sold in Europe and the United States had been contaminated with a potent carcinogen called N-nitrosodimethylamine (NDMA). This contamination was specific to valsartan substances manufactured by Zhejiang Huahai Pharmaceuticals, a company in Linhai, China. <\/span><span style=\"font-weight: 400\"><br \/>\n<\/span><span style=\"font-weight: 400\"><br \/>\n<\/span><a href=\"http:\/\/www.ema.europa.eu\/ema\/index.jsp?curl=pages\/news_and_events\/news\/2018\/08\/news_detail_003000.jsp&amp;mid=WC0b01ac058004d5c1\"><span style=\"font-weight: 400\">Medical agencies across Europe<\/span><\/a><span style=\"font-weight: 400\"> as well as the US Food and Drug Administration immediately withdrew all contaminated products from the market. However, it is believed that the contamination began six years ago as it seems to be related to a change in the manufacturing process that was implemented in 2012. From animal studies, we know that NDMA is a potent carcinogen, but unfortunately, no human data are available. <\/span><\/p>\n<p><span style=\"font-weight: 400\">In collaboration with the Danish Medicines Agency, we decided to address this issue using the nationwide Danish health registries. Due to the public health implications, we aimed to provide answers as quickly as possible. That sense of urgency was shared by our collaborators at the Danish Medicines Agency, the Danish Health Data Authority, and the reviewers and editorial board at <\/span><i><span style=\"font-weight: 400\">The BMJ<\/span><\/i><span style=\"font-weight: 400\">, who all contributed greatly to expediting the process. Thus, we could publish these findings in <\/span><i><span style=\"font-weight: 400\">The BMJ<\/span><\/i><span style=\"font-weight: 400\"> only ten weeks after the NDMA contamination was first announced. We think of this study as a proof-of-concept study in that expedited pharmacoepidemiologic assessment is possible and has its place in such urgent public health matters. <\/span><\/p>\n<p><span style=\"font-weight: 400\">We are able to provide some reassurance with this study, as NDMA contaminated valsartan products showed no association with an increased risk of cancers in general compared with exposure to non-contaminated valsartan products. An interesting feature of our study was that we were able to compare patients who had unknowingly taken NDMA contaminated valsartan products with patients who had taken non-contaminated valsartan products, thus ensuring a high degree of comparability. Although our results are generally reassuring, uncertainty remains regarding both individual cancer outcomes and long-term cancer risk. For individual cancers, we observed increases in risk of colorectal and uterine cancer, however, with wide confidence intervals that included the null. Further, the limited follow-up time (median of 4.6 years) constitutes the main limitation to the study. As such, we are not able to infer anything about later carcinogenic effects. Our results do not imply an increase in short-term overall cancer risk from use of valsartan products contaminated with NDMA. We plan to follow up on these findings with regards to exposure classification once data on actual NDMA content become available and eventually to assess long-term risks. <\/span><\/p>\n<p><strong>Anton Potteg\u00e5rd<\/strong><i><span style=\"font-weight: 400\">, associate professor,\u00a0<\/span><\/i><span style=\"font-weight: 400\">Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark<\/span><\/p>\n<p><span style=\"font-weight: 400\"><strong>Kasper Bruun Kristensen<\/strong>, <\/span><i><span style=\"font-weight: 400\">research fellow,\u00a0<\/span><\/i><span style=\"font-weight: 400\">Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark<\/span><\/p>\n<p><span style=\"font-weight: 400\"><strong>Martin Thomsen Ernst<\/strong>, <\/span><i><span style=\"font-weight: 400\">data manager,\u00a0<\/span><\/i><span style=\"font-weight: 400\">Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark<\/span><\/p>\n<p><span style=\"font-weight: 400\"><strong>Nanna Borup Johansen<\/strong>, <\/span><i><span style=\"font-weight: 400\">senior medical officer,\u00a0<\/span><\/i><span style=\"font-weight: 400\">Medical Evaluation &amp; Biostatistics, Danish Medicines Agency, Copenhagen, Denmark<\/span><\/p>\n<p><span style=\"font-weight: 400\"><strong>Pierre Quartarolo<\/strong>, <\/span><i><span style=\"font-weight: 400\">director of division,\u00a0<\/span><\/i><span style=\"font-weight: 400\">Pharmacovigilance and Medical Devices, Danish Medicines Agency, Copenhagen, Denmark<\/span><\/p>\n<p><strong>Jesper Hallas<\/strong><i><span style=\"font-weight: 400\">, professor,\u00a0<\/span><\/i><span style=\"font-weight: 400\">Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark<\/span><\/p>\n<p><em><strong>Competing interests<\/strong>: Please <a href=\"https:\/\/www.bmj.com\/content\/362\/bmj.k3851\">see full details on the research paper.<\/a>\u00a0<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>This July, it was discovered that some valsartan products (used for treatment of hypertension and heart failure) sold in Europe and the United States had been contaminated with a potent [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/bmj\/2018\/09\/12\/fast-tracked-pharmacoepidemiology-in-drug-safety-issues\/\">More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[18894],"tags":[],"class_list":["post-43018","post","type-post","status-publish","format-standard","hentry","category-authors-perspective"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Fast-tracked pharmacoepidemiology in drug safety issues - The BMJ<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.bmj.com\/bmj\/2018\/09\/12\/fast-tracked-pharmacoepidemiology-in-drug-safety-issues\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Fast-tracked pharmacoepidemiology in drug safety issues - The BMJ\" \/>\n<meta property=\"og:description\" content=\"This July, it was discovered that some valsartan products (used for treatment of hypertension and heart failure) sold in Europe and the United States had been contaminated with a potent [...]More...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.bmj.com\/bmj\/2018\/09\/12\/fast-tracked-pharmacoepidemiology-in-drug-safety-issues\/\" \/>\n<meta property=\"og:site_name\" content=\"The BMJ\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/bmjdotcom\/\" \/>\n<meta property=\"article:published_time\" content=\"2018-09-12T17:00:09+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2018-09-13T07:42:34+00:00\" \/>\n<meta name=\"author\" content=\"BMJ\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@bmj_latest\" \/>\n<meta name=\"twitter:site\" content=\"@bmj_latest\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"BMJ\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/2018\\\/09\\\/12\\\/fast-tracked-pharmacoepidemiology-in-drug-safety-issues\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/2018\\\/09\\\/12\\\/fast-tracked-pharmacoepidemiology-in-drug-safety-issues\\\/\"},\"author\":{\"name\":\"BMJ\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/#\\\/schema\\\/person\\\/ba3da426ed20e8f1d933ca367d8216fe\"},\"headline\":\"Fast-tracked pharmacoepidemiology in drug safety issues\",\"datePublished\":\"2018-09-12T17:00:09+00:00\",\"dateModified\":\"2018-09-13T07:42:34+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/2018\\\/09\\\/12\\\/fast-tracked-pharmacoepidemiology-in-drug-safety-issues\\\/\"},\"wordCount\":536,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/#organization\"},\"articleSection\":[\"Author's perspective\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/2018\\\/09\\\/12\\\/fast-tracked-pharmacoepidemiology-in-drug-safety-issues\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/2018\\\/09\\\/12\\\/fast-tracked-pharmacoepidemiology-in-drug-safety-issues\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/2018\\\/09\\\/12\\\/fast-tracked-pharmacoepidemiology-in-drug-safety-issues\\\/\",\"name\":\"Fast-tracked pharmacoepidemiology in drug safety issues - The BMJ\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/#website\"},\"datePublished\":\"2018-09-12T17:00:09+00:00\",\"dateModified\":\"2018-09-13T07:42:34+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/2018\\\/09\\\/12\\\/fast-tracked-pharmacoepidemiology-in-drug-safety-issues\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/2018\\\/09\\\/12\\\/fast-tracked-pharmacoepidemiology-in-drug-safety-issues\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/2018\\\/09\\\/12\\\/fast-tracked-pharmacoepidemiology-in-drug-safety-issues\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Fast-tracked pharmacoepidemiology in drug safety issues\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/#website\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/\",\"name\":\"The BMJ\",\"description\":\"Helping doctors make better decisions.\",\"publisher\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/#organization\",\"name\":\"The BMJ\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/files\\\/2018\\\/05\\\/The-BMJ-logo.jpg\",\"contentUrl\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/files\\\/2018\\\/05\\\/The-BMJ-logo.jpg\",\"width\":852,\"height\":568,\"caption\":\"The BMJ\"},\"image\":{\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/bmjdotcom\\\/\",\"https:\\\/\\\/x.com\\\/bmj_latest\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/#\\\/schema\\\/person\\\/ba3da426ed20e8f1d933ca367d8216fe\",\"name\":\"BMJ\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/b4d8f39281bcae118348a1c027347b8e53b82d42520e774a8b50dd9a6ac6c01d?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/b4d8f39281bcae118348a1c027347b8e53b82d42520e774a8b50dd9a6ac6c01d?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/b4d8f39281bcae118348a1c027347b8e53b82d42520e774a8b50dd9a6ac6c01d?s=96&d=mm&r=g\",\"caption\":\"BMJ\"},\"sameAs\":[\"https:\\\/\\\/blogs.bmj.com\\\/\"],\"url\":\"https:\\\/\\\/blogs.bmj.com\\\/bmj\\\/author\\\/admin\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Fast-tracked pharmacoepidemiology in drug safety issues - The BMJ","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/blogs.bmj.com\/bmj\/2018\/09\/12\/fast-tracked-pharmacoepidemiology-in-drug-safety-issues\/","og_locale":"en_US","og_type":"article","og_title":"Fast-tracked pharmacoepidemiology in drug safety issues - The BMJ","og_description":"This July, it was discovered that some valsartan products (used for treatment of hypertension and heart failure) sold in Europe and the United States had been contaminated with a potent [...]More...","og_url":"https:\/\/blogs.bmj.com\/bmj\/2018\/09\/12\/fast-tracked-pharmacoepidemiology-in-drug-safety-issues\/","og_site_name":"The BMJ","article_publisher":"https:\/\/www.facebook.com\/bmjdotcom\/","article_published_time":"2018-09-12T17:00:09+00:00","article_modified_time":"2018-09-13T07:42:34+00:00","author":"BMJ","twitter_card":"summary_large_image","twitter_creator":"@bmj_latest","twitter_site":"@bmj_latest","twitter_misc":{"Written by":"BMJ","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/blogs.bmj.com\/bmj\/2018\/09\/12\/fast-tracked-pharmacoepidemiology-in-drug-safety-issues\/#article","isPartOf":{"@id":"https:\/\/blogs.bmj.com\/bmj\/2018\/09\/12\/fast-tracked-pharmacoepidemiology-in-drug-safety-issues\/"},"author":{"name":"BMJ","@id":"https:\/\/blogs.bmj.com\/bmj\/#\/schema\/person\/ba3da426ed20e8f1d933ca367d8216fe"},"headline":"Fast-tracked pharmacoepidemiology in drug safety issues","datePublished":"2018-09-12T17:00:09+00:00","dateModified":"2018-09-13T07:42:34+00:00","mainEntityOfPage":{"@id":"https:\/\/blogs.bmj.com\/bmj\/2018\/09\/12\/fast-tracked-pharmacoepidemiology-in-drug-safety-issues\/"},"wordCount":536,"commentCount":0,"publisher":{"@id":"https:\/\/blogs.bmj.com\/bmj\/#organization"},"articleSection":["Author's perspective"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/blogs.bmj.com\/bmj\/2018\/09\/12\/fast-tracked-pharmacoepidemiology-in-drug-safety-issues\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/blogs.bmj.com\/bmj\/2018\/09\/12\/fast-tracked-pharmacoepidemiology-in-drug-safety-issues\/","url":"https:\/\/blogs.bmj.com\/bmj\/2018\/09\/12\/fast-tracked-pharmacoepidemiology-in-drug-safety-issues\/","name":"Fast-tracked pharmacoepidemiology in drug safety issues - The BMJ","isPartOf":{"@id":"https:\/\/blogs.bmj.com\/bmj\/#website"},"datePublished":"2018-09-12T17:00:09+00:00","dateModified":"2018-09-13T07:42:34+00:00","breadcrumb":{"@id":"https:\/\/blogs.bmj.com\/bmj\/2018\/09\/12\/fast-tracked-pharmacoepidemiology-in-drug-safety-issues\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/blogs.bmj.com\/bmj\/2018\/09\/12\/fast-tracked-pharmacoepidemiology-in-drug-safety-issues\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/blogs.bmj.com\/bmj\/2018\/09\/12\/fast-tracked-pharmacoepidemiology-in-drug-safety-issues\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/blogs.bmj.com\/bmj\/"},{"@type":"ListItem","position":2,"name":"Fast-tracked pharmacoepidemiology in drug safety issues"}]},{"@type":"WebSite","@id":"https:\/\/blogs.bmj.com\/bmj\/#website","url":"https:\/\/blogs.bmj.com\/bmj\/","name":"The BMJ","description":"Helping doctors make better decisions.","publisher":{"@id":"https:\/\/blogs.bmj.com\/bmj\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/blogs.bmj.com\/bmj\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/blogs.bmj.com\/bmj\/#organization","name":"The BMJ","url":"https:\/\/blogs.bmj.com\/bmj\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/blogs.bmj.com\/bmj\/#\/schema\/logo\/image\/","url":"https:\/\/blogs.bmj.com\/bmj\/files\/2018\/05\/The-BMJ-logo.jpg","contentUrl":"https:\/\/blogs.bmj.com\/bmj\/files\/2018\/05\/The-BMJ-logo.jpg","width":852,"height":568,"caption":"The BMJ"},"image":{"@id":"https:\/\/blogs.bmj.com\/bmj\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/bmjdotcom\/","https:\/\/x.com\/bmj_latest"]},{"@type":"Person","@id":"https:\/\/blogs.bmj.com\/bmj\/#\/schema\/person\/ba3da426ed20e8f1d933ca367d8216fe","name":"BMJ","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/b4d8f39281bcae118348a1c027347b8e53b82d42520e774a8b50dd9a6ac6c01d?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/b4d8f39281bcae118348a1c027347b8e53b82d42520e774a8b50dd9a6ac6c01d?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/b4d8f39281bcae118348a1c027347b8e53b82d42520e774a8b50dd9a6ac6c01d?s=96&d=mm&r=g","caption":"BMJ"},"sameAs":["https:\/\/blogs.bmj.com\/"],"url":"https:\/\/blogs.bmj.com\/bmj\/author\/admin\/"}]}},"_links":{"self":[{"href":"https:\/\/blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/posts\/43018","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/comments?post=43018"}],"version-history":[{"count":0,"href":"https:\/\/blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/posts\/43018\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/media?parent=43018"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/categories?post=43018"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.bmj.com\/bmj\/wp-json\/wp\/v2\/tags?post=43018"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}