{"id":42541,"date":"2018-07-06T16:26:43","date_gmt":"2018-07-06T15:26:43","guid":{"rendered":"https:\/\/blogs.bmj.com\/bmj\/?p=42541"},"modified":"2018-07-20T13:20:50","modified_gmt":"2018-07-20T12:20:50","slug":"jeffrey-aronson-use-word-saintly-medical-specialties","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/bmj\/2018\/07\/06\/jeffrey-aronson-use-word-saintly-medical-specialties\/","title":{"rendered":"Jeffrey Aronson: When I use a word . . . Saintly medical specialties"},"content":{"rendered":"<p><a href=\"https:\/\/blogs.bmj.com\/bmj\/files\/2014\/12\/jeffrey_aronson.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"alignleft wp-image-32935\" src=\"https:\/\/blogs.bmj.com\/bmj\/files\/2014\/12\/jeffrey_aronson-223x300.jpg\" alt=\"jeffrey_aronson\" width=\"122\" height=\"146\" \/><\/a><span style=\"font-weight: 400\">From the earliest times religion has influenced medicine and vice versa. For example, if obeying a religious law compromises one\u2019s health, the law may sometimes be broken. Jewish law dictates that anyone who is seriously ill, or may become seriously ill by fasting, is not allowed to fast on Yom Kippur, the Jewish Day of Atonement; <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25123516\"><span style=\"font-weight: 400\">evidence<\/span><\/a><span style=\"font-weight: 400\"> that fasting for 25 hours on Yom Kippur independently increases the risk of a preterm delivery suggests that this prohibition on fasting should be extended to pregnant women, at least in their final trimester.<\/span><\/p>\n<p><span style=\"font-weight: 400\">Gods and saints have also often been invoked for medical reasons. For example, in his <\/span><a href=\"https:\/\/www.bmj.com\/content\/321\/7276\/1599\"><span style=\"font-weight: 400\">autopathography<\/span><\/a> <i><span style=\"font-weight: 400\">The Sacred Orations<\/span><\/i><span style=\"font-weight: 400\"> (AD 170\/171), Aelius Aristides gave an account of his ill health, praising the Greek God of medicine, Apollo, and criticizing his physicians.<\/span><\/p>\n<p><a href=\"https:\/\/blogs.bmj.com\/bmj\/2018\/06\/29\/jeffrey-aronson-use-word-circle-squarers-st-vitus\"><span style=\"font-weight: 400\">Last week<\/span><\/a><span style=\"font-weight: 400\"> I discussed St Vitus and his dance. Many other religious figures associated with illnesses are listed in a <\/span><a href=\"https:\/\/en.wikipedia.org\/wiki\/Patron_saints_of_ailments,_illness,_and_dangers\"><span style=\"font-weight: 400\">Wikipedia page<\/span><\/a><span style=\"font-weight: 400\"> titled \u201cPatron saints of ailments, illness, and dangers\u201d. Here is a selection of patron saints of particular medical specialties.<\/span><\/p>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19986442\"><span style=\"font-weight: 400\">Saint Blaise<\/span><\/a><span style=\"font-weight: 400\"> or <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15733587\"><span style=\"font-weight: 400\">Blasius<\/span><\/a><span style=\"font-weight: 400\">, who was martyred in 316 AD by Agricola, the governor of Cappadocia, for failing to renounce his Christian faith during the reign of Diocletian, started his career in Armenia as a general practitioner. He specialized in treating diseases of the throat, coughs, quinsy, goitre, whooping-cough, and children\u2019s diseases. Agricola had him scourged and thrown into prison. He was then tied to a stake and his flesh was torn with nails and iron combs. After being imprisoned again, he was thrown into a deep lake, with a large stone tied round his neck. When he rose to the surface and walked on the waters he was beheaded. As he died he prayed that he might be allowed to help all those with diseases of the throat. He is therefore the patron saint of laryngology. His Saint\u2019s Day is 3 February.<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-42543 alignnone\" src=\"https:\/\/blogs.bmj.com\/bmj\/files\/2018\/07\/aronson_saintly.jpg\" alt=\"\" width=\"313\" height=\"495\" srcset=\"https:\/\/blogs.bmj.com\/bmj\/files\/2018\/07\/aronson_saintly.jpg 313w, https:\/\/blogs.bmj.com\/bmj\/files\/2018\/07\/aronson_saintly-190x300.jpg 190w\" sizes=\"auto, (max-width: 313px) 100vw, 313px\" \/><\/p>\n<p><span style=\"font-weight: 400\">Saint Blaise, by prayer miraculously curing a child of a fish bone in the throat (a spiritual Heimlich manoeuvre?); the legend reads \u201cHeil. Blasii, Bischoff u[nd] Martyr, sonderbahrer Patron in denen gef\u00e4hrlichen Halssschmerzen.\u201d (\u201cHail, Blaise, bishop and martyr, special patron of those with serious pain in the throat\u201d); from a prayer leaflet, 304 AD (<\/span><a href=\"https:\/\/wellcomecollection.org\/works\/a3v3jz2h?query=saint%20blaise&amp;page=1\"><span style=\"font-weight: 400\">Wellcome Images<\/span><\/a><span style=\"font-weight: 400\"> CC BY 4.0)<\/span><\/p>\n<p><span style=\"font-weight: 400\">The patron saint of ophthalmology is <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10327126\"><span style=\"font-weight: 400\">Saint Lucy<\/span><\/a><span style=\"font-weight: 400\">, of whom various stories are told. In one version she found when she was 13 that when she looked at a man her mind became filled with sinful thoughts, and the more she looked, the more she sinned. She therefore plucked out her own eyes. In <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19778987\"><span style=\"font-weight: 400\">another version<\/span><\/a><span style=\"font-weight: 400\"> she wanted to discourage a persistent suitor who admired her eyes. In a third version, her eyes were gouged out during her martyrdom by Paschasius, the governor of Syracuse, during the reign of Diocletian.\u00a0In all versions her eyes were restored by divine intervention. It may not be entirely coincidental that her name comes from the Latin word for light, lux. Her Saint\u2019s Day is 13 December, commemorated in a poem by John Donne, <em>A Nocturnal upon St. Lucy&#8217;s Day, being the shortest day<\/em> (1627).<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-42545\" src=\"https:\/\/blogs.bmj.com\/bmj\/files\/2018\/07\/aronson_saintly2.jpg\" alt=\"\" width=\"324\" height=\"465\" srcset=\"https:\/\/blogs.bmj.com\/bmj\/files\/2018\/07\/aronson_saintly2.jpg 324w, https:\/\/blogs.bmj.com\/bmj\/files\/2018\/07\/aronson_saintly2-209x300.jpg 209w\" sizes=\"auto, (max-width: 324px) 100vw, 324px\" \/><\/p>\n<p><span style=\"font-weight: 400\">In this 15th century painting by Francesco del Cossa (ca 1430\u2013ca 1477), Saint Lucy is seen holding her original pair of eyes in her left hand.<\/span><\/p>\n<figure id=\"attachment_42546\" aria-describedby=\"caption-attachment-42546\" style=\"width: 204px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-42546\" src=\"https:\/\/blogs.bmj.com\/bmj\/files\/2018\/07\/aronson_saintly3.jpg\" alt=\"\" width=\"204\" height=\"304\" srcset=\"https:\/\/blogs.bmj.com\/bmj\/files\/2018\/07\/aronson_saintly3.jpg 308w, https:\/\/blogs.bmj.com\/bmj\/files\/2018\/07\/aronson_saintly3-201x300.jpg 201w\" sizes=\"auto, (max-width: 204px) 100vw, 204px\" \/><figcaption id=\"caption-attachment-42546\" class=\"wp-caption-text\">Saint Ren\u00e9 Goupil<\/figcaption><\/figure>\n<p><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/29247281\"><span style=\"font-weight: 400\">Ren\u00e9 Goupil<\/span><\/a><span style=\"font-weight: 400\"> (1608\u201342) was a French surgeon and lay missionary who worked in the H\u00f4tel Dieu de Qu\u00e9bec. While on a mission to Huron territory, he and his group were captured by Canadian Indians and tortured. However, he gave them medical assistance when they needed it, concerned as he was to alleviate pain and suffering. He was canonized in 1930 and was made the <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7631572\"><span style=\"font-weight: 400\">patron saint of anaesthesia<\/span><\/a><span style=\"font-weight: 400\"> in 1951. His Saint\u2019s Day in Canada is 29 September.<\/span><\/p>\n<p><span style=\"font-weight: 400\">Who should be the patron saint of pharmacology and clinical pharmacology? Drug actions are mediated by chemical signalling, and chemical recognition is the function of <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/16402126\"><span style=\"font-weight: 400\">receptors<\/span><\/a><span style=\"font-weight: 400\">, which are major targets of many important medicines. The mechanism whereby drug\u2013receptor interactions are translated into therapeutic outcomes involves chemical transmission by substances generally known as <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27481708\"><span style=\"font-weight: 400\">second messengers<\/span><\/a><span style=\"font-weight: 400\">. So, no saint is better qualified to be the patron saint of pharmacology than God\u2019s great messenger himself, the archangel Gabriel.<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-42547 alignnone\" src=\"https:\/\/blogs.bmj.com\/bmj\/files\/2018\/07\/aronson_saintly4.jpg\" alt=\"\" width=\"385\" height=\"464\" srcset=\"https:\/\/blogs.bmj.com\/bmj\/files\/2018\/07\/aronson_saintly4.jpg 385w, https:\/\/blogs.bmj.com\/bmj\/files\/2018\/07\/aronson_saintly4-249x300.jpg 249w\" sizes=\"auto, (max-width: 385px) 100vw, 385px\" \/><\/p>\n<p><i><span style=\"font-weight: 400\">The Annunciation<\/span><\/i><span style=\"font-weight: 400\"> (1501) by <\/span><a href=\"https:\/\/www.wikiart.org\/en\/pinturicchio\/the-annunciation-1501\"><span style=\"font-weight: 400\">Pinturicchio<\/span><\/a><span style=\"font-weight: 400\">. Gabriel\u2019s feast day was originally celebrated on 18 March, but since 1969 the Church of England has celebrated it on 29 September<\/span><\/p>\n<p><span style=\"font-weight: 400\">In his capacity as a messenger Gabriel appears to the prophet Daniel, explaining his visions (Daniel 8:16 and 9:21), to Zacharias and his wife, foretelling the birth of John the Baptist (Luke 1:11), and to the Virgin Mary, foretelling the birth of Jesus (Luke 1:26).<\/span><\/p>\n<p><span style=\"font-weight: 400\">In Hebrew, Gabriel\u2019s name, <\/span><span style=\"font-weight: 400\">\u05d2\u05d1\u05e8\u05d9\u05d0\u05dc<\/span><span style=\"font-weight: 400\">, means God is my strength, which is also highly appropriate for pharmacology, reminding us of the centrality of the <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26119837\"><span style=\"font-weight: 400\">dose-response curve<\/span><\/a><span style=\"font-weight: 400\"> to pharmacological actions: the more of a medicine you give, the bigger the effect.<\/span><\/p>\n<p><span style=\"font-weight: 400\">So we should celebrate Pharmacology Day on Saint Gabriel\u2019s Day, 29 September. It will be followed this year by Clinical Pharmacology Month, October, with a range of activities, including case presentations at grand rounds and prize competitions for medical students.<\/span><\/p>\n<p><em><strong>Jeffrey Aronson<\/strong>\u00a0is a clinical pharmacologist, working in the Centre for Evidence Based Medicine in Oxford&#8217;s Nuffield Department of Primary Care Health Sciences. He is also president emeritus of the British Pharmacological Society.<\/em><\/p>\n<p><strong>Competing interests:<\/strong>\u00a0None declared.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>From the earliest times religion has influenced medicine and vice versa. For example, if obeying a religious law compromises one\u2019s health, the law may sometimes be broken. Jewish law dictates [&#8230;]<\/p>\n<p><a class=\"btn btn-secondary understrap-read-more-link\" href=\"https:\/\/blogs.bmj.com\/bmj\/2018\/07\/06\/jeffrey-aronson-use-word-saintly-medical-specialties\/\">More&#8230;<\/a><\/p>\n","protected":false},"author":1,"featured_media":42548,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5762],"tags":[],"class_list":["post-42541","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-jeff-aronsons-words"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Jeffrey Aronson: When I use a word . . . 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