{"id":41741,"date":"2018-03-29T11:39:00","date_gmt":"2018-03-29T10:39:00","guid":{"rendered":"https:\/\/blogs.bmj.com\/bmj\/?p=41741"},"modified":"2018-04-17T08:56:32","modified_gmt":"2018-04-17T07:56:32","slug":"nick-devito-and-ben-goldacre-unreported-clinical-trial-of-the-week-nct02133326","status":"publish","type":"post","link":"https:\/\/blogs.bmj.com\/bmj\/2018\/03\/29\/nick-devito-and-ben-goldacre-unreported-clinical-trial-of-the-week-nct02133326\/","title":{"rendered":"Unreported clinical trial of the week: analgesics after third molar extraction (NCT02133326)"},"content":{"rendered":"

Nicholas J DeVito and Ben Goldacre<\/strong><\/p>\n

Background<\/strong><\/p>\n

The US FDA Amendments Act (FDAAA 2007) requires certain clinical trials to report their results on ClinicalTrials.gov within one year of completion. Our <\/span>FDAAA TrialsTracker<\/span><\/a> shows all individual trials that <\/span>breach<\/span><\/a> this legal requirement. Once a week, we write about one unreported clinical trial: you can read more background <\/span>here<\/span><\/a>.<\/span><\/p>\n

Trial NCT02133326<\/b><\/p>\n

This week\u2019s unreported study is: \u201cAssessment of Preemptive Analgesic Effect of Caldolor\u00ae vs. Ofirmev\u00ae on Third Molar Surgery: A Prospective, Randomized, Double-blinded Clinical Trial\u201d (<\/span>NCT02133326<\/span><\/a>). The participants were 67 adults, each having at least two teeth removed. Participants were randomised to receive either intravenous ibuprofen, or intravenous paracetamol (\u201cacetaminophen\u201d), prior to surgery. The primary outcome was postoperative pain, as measured on a <\/span>visual analogue scale<\/span><\/a> during the week after surgery. The secondary outcome was the amount of pain medication consumed. The trial was double blinded, and began in March 2014. The completion date given is January 2017, and the trial\u2019s registry record was last updated by the researchers in January 2017.<\/span><\/p>\n

Discussion<\/b><\/p>\n

This is an important trial whose results would be valuable for clinicians and patients. The condition is common: impacted wisdom teeth are <\/span>seen<\/span><\/a> throughout<\/span><\/a> the world<\/span><\/a>, and surgical removal is <\/span>very common<\/span><\/a>, with <\/span>10 million operations per year in the US<\/span><\/a>. No one likes to be in pain, and knowing the relative merits of one drug over another in preventing postoperative pain for common procedures can have a huge impact on quality of life. This study is particularly relevant given the growing opioid crisis: dentists are proportionally the <\/span>largest prescribers of opioid medication in the US.<\/span><\/a> The secondary outcome of the trial assessed reduction in use of postoperative analgesics.<\/span><\/p>\n

Conclusion<\/b><\/p>\n

This unreported trial was sponsored by Tufts University School of Dental Medicine in Massachusetts, where it was also conducted. The primary investigator is Dr Archana Viswanath. We hope that the investigators will share the results of this trial soon.<\/span><\/p>\n

\"\"<\/a>Ben Goldacre <\/b>is a doctor, author, and director of the EBM DataLab at the University of Oxford. He co-founded the AllTrials campaign for trials transparency.<\/b><\/em><\/p>\n

Competing interests:<\/strong>\u00a0BG has received research funding from the Laura and John Arnold Foundation, the Wellcome Trust, the Oxford Biomedical Research Centre, the NHS National Institute for Health Research School of Primary Care Research, the Health Foundation, and the World Health Organization; he also receives personal income from speaking and writing for lay audiences on the misuse of science. ND is employed on BG’s LJAF grant.<\/p>\n

\n
\n

\"\"<\/a><\/span><\/strong><\/em><\/p>\n

 <\/p>\n

Nicholas<\/span>\u00a0J DeVito<\/strong> is a researcher at the EBM Datalab at the University of Oxford.<\/em><\/p>\n<\/div>\n

\n

Competing interests:\u00a0<\/b>ND is employed on BG’s LJAF grant.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Nicholas J DeVito and Ben Goldacre Background The US FDA Amendments Act (FDAAA 2007) requires certain clinical trials to report their results on ClinicalTrials.gov within one year of completion. Our […]<\/p>\n

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